| 1 |
Clarus Ventures, LLC |
3,959,440 |
61,055,000 |
26.42% |
|
|
| 2 |
Redmile Group, LLC |
1,459,742 |
22,509,000 |
9.74% |
|
|
| 3 |
CADIAN CAPITAL MANAGEMENT, LP |
1,241,736 |
19,148,000 |
8.29% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,232,696 |
19,008,000 |
8.23% |
|
|
| 5 |
MORGAN STANLEY |
957,953 |
14,771,000 |
6.39% |
|
|
| 6 |
Cortina Asset Management, LLC |
831,449 |
12,821,000 |
5.55% |
|
|
| 7 |
MILLENNIUM MANAGEMENT LLC |
529,975 |
8,172,000 |
3.54% |
|
|
| 8 |
Foresite Capital Management II, LLC |
464,486 |
7,162,000 |
3.10% |
|
|
| 9 |
Consonance Capital Management LP |
449,325 |
6,929,000 |
3.00% |
|
|
| 10 |
Ghost Tree Capital, LLC |
400,000 |
6,168,000 |
2.67% |
|
|
| 11 |
BlackRock Fund Advisors |
333,828 |
5,148,000 |
2.23% |
|
|
| 12 |
VANGUARD GROUP INC |
296,006 |
4,564,000 |
1.97% |
|
|
| 13 |
GENERAL ELECTRIC CO |
233,793 |
3,605,000 |
1.56% |
|
|
| 14 |
Pier Capital, LLC |
220,265 |
3,396,000 |
1.47% |
|
|
| 15 |
ALTRINSIC GLOBAL ADVISORS LLC |
196,711 |
3,033,000 |
1.31% |
|
|
| 16 |
Endurant Capital Management LP |
175,961 |
2,713,000 |
1.17% |
|
|
| 17 |
Nicholas Investment Partners, LP |
165,077 |
2,545,000 |
1.10% |
|
|
| 18 |
GILDER GAGNON HOWE & CO LLC |
153,957 |
2,374,000 |
1.03% |
|
|
| 19 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
138,949 |
2,143,000 |
0.93% |
|
|
| 20 |
STATE STREET CORP |
133,111 |
2,054,000 |
0.89% |
|
|
| 21 |
JHL Capital Group LLC |
130,000 |
2,005,000 |
0.87% |
|
|
| 22 |
DSC Advisors, L.P. |
117,136 |
1,806,000 |
0.78% |
|
|
| 23 |
Bank of New York Mellon Corp |
109,250 |
1,684,000 |
0.73% |
|
|
| 24 |
HIGHLAND CAPITAL MANAGEMENT LP |
107,100 |
1,651,000 |
0.71% |
|
|
| 25 |
NORTHERN TRUST CORP |
106,116 |
1,637,000 |
0.71% |
|
|
| 26 |
BlackRock Institutional Trust Company, N.A. |
105,874 |
1,633,000 |
0.71% |
|
|
| 27 |
Cormorant Asset Management, LP |
80,000 |
1,234,000 |
0.53% |
|
|
| 28 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
72,700 |
1,121,000 |
0.49% |
|
|
| 29 |
GEODE CAPITAL MANAGEMENT, LLC |
63,408 |
977,000 |
0.42% |
|
|
| 30 |
Opus Point Partners Management, LLC |
60,000 |
925,000 |
0.40% |
|
|
| 31 |
JPMORGAN CHASE & CO |
54,465 |
840,000 |
0.36% |
|
|
| 32 |
BlackRock Investment Management, LLC |
44,505 |
686,000 |
0.30% |
|
|
| 33 |
STRS OHIO |
43,400 |
669,000 |
0.29% |
|
|
| 34 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
41,499 |
640,000 |
0.28% |
|
|
| 35 |
Quantitative Systematic Strategies LLC |
39,867 |
600,000 |
0.26% |
|
|
| 36 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
29,000 |
447,000 |
0.19% |
|
|
| 37 |
NEW YORK STATE COMMON RETIREMENT FUND |
25,797 |
398,000 |
0.17% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
23,284 |
359,000 |
0.16% |
|
|
| 39 |
Spot Trading L.L.C |
22,000 |
339,000 |
0.15% |
Call |
|
| 40 |
Spark Investment Management LLC |
21,500 |
331,000 |
0.14% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
18,823 |
290,000 |
0.13% |
|
|
| 42 |
BAIRD FINANCIAL GROUP, INC. |
14,842 |
229,000 |
0.10% |
|
|
| 43 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
14,700 |
227,000 |
0.10% |
|
|
| 44 |
RHUMBLINE ADVISERS |
11,030 |
170,000 |
0.07% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
9,281 |
143,000 |
0.06% |
|
|
| 46 |
Nationwide Fund Advisors |
8,182 |
126,000 |
0.05% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
7,588 |
117,000 |
0.05% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,471 |
115,203 |
0.05% |
|
|
| 49 |
BLACKROCK ADVISORS LLC |
6,373 |
98,000 |
0.04% |
|
|
| 50 |
PANAGORA ASSET MANAGEMENT INC |
6,070 |
94,000 |
0.04% |
|
|
