| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 3,959,440 | 78,674,000 | 20.35% | ||
| 2 | CADIAN CAPITAL MANAGEMENT, LP | 2,032,792 | 40,392,000 | 10.45% | ||
| 3 | MORGAN STANLEY | 1,886,772 | 37,490,000 | 9.70% | ||
| 4 | BlackRock Finance, Inc. | 1,333,264 | 26,492,000 | 6.85% | ||
| 5 | Redmile Group, LLC | 934,424 | 18,567,000 | 4.80% | ||
| 6 | JENNISON ASSOCIATES LLC | 800,930 | 15,914,000 | 4.12% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 673,174 | 13,376,000 | 3.46% | ||
| 8 | VANGUARD GROUP INC | 588,558 | 11,695,000 | 3.03% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 509,051 | 10,115,000 | 2.62% | ||
| 10 | Foresite Capital Management II, LLC | 492,539 | 9,787,000 | 2.53% | ||
| 11 | HOMESTEAD ADVISERS CORP | 492,000 | 9,776,000 | 2.53% | ||
| 12 | DSC Advisors, L.P. | 465,000 | 9,240,000 | 2.39% | ||
| 13 | Ghost Tree Capital, LLC | 400,000 | 7,948,000 | 2.06% | ||
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 352,375 | 7,002,000 | 1.81% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 350,000 | 6,955,000 | 1.80% | ||
| 16 | FORESITE CAPITAL MANAGEMENT III, LLC | 318,586 | 6,330,000 | 1.64% | ||
| 17 | Spark Investment Management LLC | 258,300 | 5,132,000 | 1.33% | ||
| 18 | STATE STREET CORP | 231,000 | 4,591,000 | 1.19% | ||
| 19 | Lombard Odier Asset Management (USA) Corp | 210,500 | 4,183,000 | 1.08% | ||
| 20 | NORTHERN TRUST CORP | 206,225 | 4,098,000 | 1.06% | ||
| 21 | Polar Capital LLP | 200,000 | 3,974,000 | 1.03% | ||
| 22 | ACUTA CAPITAL PARTNERS, LLC | 164,932 | 3,277,000 | 0.85% | ||
| 23 | PURA VIDA INVESTMENTS, LLC | 142,750 | 2,836,000 | 0.73% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 134,361 | 2,670,000 | 0.69% | ||
| 25 | CREDIT SUISSE AG/ | 133,841 | 2,660,000 | 0.69% | ||
| 26 | Penn Capital Management Company, LLC | 120,878 | 2,402,000 | 0.62% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 120,246 | 2,388,000 | 0.62% | ||
| 28 | Numeric Investors LLC | 115,831 | 2,302,000 | 0.60% | ||
| 29 | First Light Asset Management, LLC | 114,755 | 2,280,000 | 0.59% | ||
| 30 | Tekla Capital Management LLC | 113,500 | 2,255,000 | 0.58% | ||
| 31 | PLATINUM INVESTMENT MANAGEMENT LTD | 92,000 | 1,828,000 | 0.47% | ||
| 32 | Endurant Capital Management LP | 88,300 | 1,755,000 | 0.45% | ||
| 33 | Bank of New York Mellon Corp | 86,312 | 1,715,000 | 0.44% | ||
| 34 | D. E. Shaw & Co., Inc. | 75,104 | 1,492,000 | 0.39% | ||
| 35 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 74,822 | 1,486,000 | 0.38% | ||
| 36 | Granite Investment Partners, LLC | 74,319 | 1,476,000 | 0.38% | ||
| 37 | GOLDMAN SACHS GROUP INC | 71,683 | 1,424,000 | 0.37% | ||
| 38 | CITADEL ADVISORS LLC | 71,388 | 1,418,000 | 0.37% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 65,674 | 1,305,000 | 0.34% | ||
| 40 | Nicholas Investment Partners, LP | 62,469 | 1,241,000 | 0.32% | ||
| 41 | PDT Partners, LLC | 57,000 | 1,133,000 | 0.29% | ||
| 42 | FRED ALGER MANAGEMENT, LLC | 50,000 | 994,000 | 0.26% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 50,000 | 994,000 | 0.26% | Call | |
| 44 | LEVIN CAPITAL STRATEGIES, L.P. | 44,223 | 879,000 | 0.23% | ||
| 45 | TWO SIGMA INVESTMENTS, LP | 43,935 | 873,000 | 0.23% | ||
| 46 | ACADIAN ASSET MANAGEMENT LLC | 40,065 | 796,000 | 0.21% | ||
| 47 | RUSSELL INVESTMENTS GROUP, LTD. | 34,717 | 689,000 | 0.18% | ||
| 48 | STRS OHIO | 32,600 | 647,000 | 0.17% | ||
| 49 | ARK INVESTMENT MANAGEMENT LLC | 31,741 | 631,000 | 0.16% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,500 | 626,000 | 0.16% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
