| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 3,959,440 | 65,489,000 | 17.02% | ||
| 2 | CADIAN CAPITAL MANAGEMENT, LP | 2,094,408 | 34,642,000 | 9.00% | ||
| 3 | MORGAN STANLEY | 1,957,913 | 32,384,000 | 8.42% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,892,872 | 31,308,000 | 8.14% | ||
| 5 | BlackRock Finance, Inc. | 1,482,335 | 24,519,000 | 6.37% | ||
| 6 | LEVIN CAPITAL STRATEGIES, L.P. | 1,044,692 | 17,279,000 | 4.49% | ||
| 7 | Redmile Group, LLC | 866,819 | 14,337,000 | 3.73% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 865,090 | 14,309,000 | 3.72% | ||
| 9 | JENNISON ASSOCIATES LLC | 801,184 | 13,252,000 | 3.44% | ||
| 10 | VANGUARD GROUP INC | 752,699 | 12,449,000 | 3.23% | ||
| 11 | RUSSELL INVESTMENTS GROUP, LTD. | 538,792 | 8,910,000 | 2.32% | ||
| 12 | HOMESTEAD ADVISERS CORP | 521,132 | 8,620,000 | 2.24% | ||
| 13 | Endurant Capital Management LP | 509,660 | 8,430,000 | 2.19% | ||
| 14 | PURA VIDA INVESTMENTS, LLC | 398,206 | 6,586,000 | 1.71% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 378,300 | 6,257,000 | 1.63% | ||
| 16 | Ghost Tree Capital, LLC | 350,000 | 5,789,000 | 1.50% | ||
| 17 | Spark Investment Management LLC | 330,200 | 5,461,000 | 1.42% | ||
| 18 | DSC Advisors, L.P. | 326,006 | 5,392,000 | 1.40% | ||
| 19 | STATE STREET CORP | 261,864 | 4,332,000 | 1.13% | ||
| 20 | Foresite Capital Management II, LLC | 254,015 | 4,201,000 | 1.09% | ||
| 21 | MARSHALL WACE NORTH AMERICA, L.P. | 247,068 | 4,200,000 | 1.09% | ||
| 22 | D. E. Shaw & Co., Inc. | 236,006 | 3,904,000 | 1.01% | ||
| 23 | NORTHERN TRUST CORP | 228,016 | 3,771,000 | 0.98% | ||
| 24 | Polar Capital LLP | 225,000 | 3,722,000 | 0.97% | ||
| 25 | Point72 Asset Management, L.P. | 219,800 | 3,635,000 | 0.94% | ||
| 26 | FORESITE CAPITAL MANAGEMENT III, LLC | 178,681 | 2,955,000 | 0.77% | ||
| 27 | Penn Capital Management Company, LLC | 172,498 | 2,853,000 | 0.74% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 155,201 | 2,566,000 | 0.67% | ||
| 29 | CREDIT SUISSE AG/ | 134,677 | 2,227,000 | 0.58% | ||
| 30 | PRICE T ROWE ASSOCIATES INC /MD/ | 134,361 | 2,222,000 | 0.58% | ||
| 31 | First Light Asset Management, LLC | 114,702 | 1,897,000 | 0.49% | ||
| 32 | Tekla Capital Management LLC | 113,500 | 1,877,000 | 0.49% | ||
| 33 | ARK INVESTMENT MANAGEMENT LLC | 110,510 | 1,828,000 | 0.48% | ||
| 34 | SECOR Capital Advisors, LP | 96,757 | 1,600,000 | 0.42% | ||
| 35 | PLATINUM INVESTMENT MANAGEMENT LTD | 92,000 | 1,521,000 | 0.40% | ||
| 36 | Lombard Odier Asset Management (USA) Corp | 80,000 | 1,323,000 | 0.34% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 70,742 | 1,170,000 | 0.30% | ||
| 38 | GOLDMAN SACHS GROUP INC | 70,248 | 1,162,000 | 0.30% | ||
| 39 | Bank of New York Mellon Corp | 69,927 | 1,157,000 | 0.30% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,900 | 974,000 | 0.25% | Put | |
| 41 | PDT Partners, LLC | 57,047 | 944,000 | 0.25% | ||
| 42 | PANAGORA ASSET MANAGEMENT INC | 54,301 | 898,000 | 0.23% | ||
| 43 | CITADEL ADVISORS LLC | 50,474 | 835,000 | 0.22% | ||
| 44 | Candriam S.C.A. | 45,000 | 744,000 | 0.19% | ||
| 45 | FRED ALGER MANAGEMENT, LLC | 45,000 | 744,000 | 0.19% | ||
| 46 | DEUTSCHE BANK AG\ | 41,499 | 685,000 | 0.18% | ||
| 47 | Nationwide Fund Advisors | 41,098 | 680,000 | 0.18% | ||
| 48 | STRS OHIO | 40,000 | 661,000 | 0.17% | ||
| 49 | Granite Investment Partners, LLC | 37,191 | 616,000 | 0.16% | ||
| 50 | OXFORD ASSET MANAGEMENT LLP | 33,034 | 546,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
