| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 4,720,065 | 7,033,000 | 33.01% | PRN | |
| 2 | Newtyn Management, LLC | 2,700,000 | 4,023,000 | 18.88% | ||
| 3 | Clearbridge Investments, LLC | 1,970,117 | 2,935,000 | 13.78% | ||
| 4 | Arbiter Partners Capital Management LLC | 1,845,787 | 2,750,000 | 12.91% | ||
| 5 | VANGUARD GROUP INC | 662,572 | 987,000 | 4.63% | ||
| 6 | 683 Capital Management, LLC | 600,000 | 894,000 | 4.20% | ||
| 7 | DELTEC ASSET MANAGEMENT LLC | 335,850 | 500,000 | 2.35% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 261,400 | 389,000 | 1.83% | ||
| 9 | WHITEBOX ADVISORS LLC | 255,650 | 381,000 | 1.79% | ||
| 10 | DEUTSCHE BANK AG\ | 191,070 | 284,000 | 1.33% | ||
| 11 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 166,500 | 248,000 | 1.16% | ||
| 12 | HealthCor Management, L.P. | 125,000 | 186,000 | 0.87% | ||
| 13 | HIGHLAND CAPITAL MANAGEMENT LP | 77,595 | 116,000 | 0.54% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 66,083 | 98,000 | 0.46% | Call | |
| 15 | CSS LLC/IL | 57,480 | 86,000 | 0.40% | ||
| 16 | Ghost Tree Capital, LLC | 55,150 | 82,000 | 0.38% | ||
| 17 | Yakira Capital Management, Inc. | 45,300 | 67,000 | 0.31% | SH | |
| 18 | LPL Financial LLC | 37,769 | 56,000 | 0.26% | ||
| 19 | GABELLI & Co INVESTMENT ADVISERS, INC. | 25,569 | 38,000 | 0.18% | ||
| 20 | MORGAN STANLEY | 22,700 | 34,000 | 0.16% | ||
| 21 | NORTHERN TRUST CORP | 19,125 | 28,000 | 0.13% | ||
| 22 | NatWest Group plc | 13,941 | 21,000 | 0.10% | ||
| 23 | GABELLI FUNDS LLC | 11,500 | 17,000 | 0.08% | ||
| 24 | TD ASSET MANAGEMENT INC | 10,300 | 15,000 | 0.07% | ||
| 25 | UBS AG | 9,252 | 14,000 | 0.07% | ||
| 26 | Tower Research Capital LLC (TRC) | 5,701 | 8,000 | 0.04% | ||
| 27 | DIMENSIONAL FUND ADVISORS LP | 2,878 | 4,000 | 0.02% | ||
| 28 | CITIGROUP INC | 3,001 | 4,000 | 0.02% | ||
| 29 | BANK OF MONTREAL /CAN/ | 1,000 | 1,000 | 0.00% | ||
| 30 | Creative Planning | 500 | 1,000 | 0.00% | ||
| 31 | CapWealth Advisors, LLC | 500 | 1,000 | 0.00% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 1,000 | 1,000 | 0.00% | ||
| 33 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 637 | 1,000 | 0.00% | ||
| 34 | BNP PARIBAS FINANCIAL MARKETS | 421 | 627 | 0.00% | ||
| 35 | AMERIPRISE FINANCIAL INC | 240 | 0 | 0.00% | ||
| 36 | WELLS FARGO & COMPANY/MN | 1 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
