| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 4,720,065 | 10,148,000 | 32.42% | PRN | |
| 2 | Newtyn Management, LLC | 2,700,000 | 5,940,000 | 18.98% | ||
| 3 | Clearbridge Investments, LLC | 1,970,117 | 4,236,000 | 13.53% | ||
| 4 | Arbiter Partners Capital Management LLC | 1,845,787 | 3,968,000 | 12.68% | ||
| 5 | HealthCor Management, L.P. | 725,000 | 1,559,000 | 4.98% | ||
| 6 | VANGUARD GROUP INC | 662,572 | 1,458,000 | 4.66% | ||
| 7 | 683 Capital Management, LLC | 600,000 | 1,290,000 | 4.12% | ||
| 8 | DEUTSCHE BANK AG\ | 176,300 | 379,000 | 1.21% | ||
| 9 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 166,500 | 366,000 | 1.17% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 149,211 | 328,000 | 1.05% | ||
| 11 | DELTEC ASSET MANAGEMENT LLC | 150,000 | 323,000 | 1.03% | ||
| 12 | Ghost Tree Capital, LLC | 134,000 | 288,000 | 0.92% | ||
| 13 | HIGHLAND CAPITAL MANAGEMENT LP | 69,326 | 149,000 | 0.48% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 66,083 | 142,000 | 0.45% | Call | |
| 15 | CSS LLC/IL | 57,480 | 124,000 | 0.40% | ||
| 16 | Yakira Capital Management, Inc. | 45,300 | 97,000 | 0.31% | ||
| 17 | LPL Financial LLC | 37,769 | 79,000 | 0.25% | ||
| 18 | MORGAN STANLEY | 35,200 | 76,000 | 0.24% | ||
| 19 | Tetragon Partners GP Ltd | 35,488 | 76,000 | 0.24% | ||
| 20 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 29,992 | 64,000 | 0.20% | ||
| 21 | GABELLI & Co INVESTMENT ADVISERS, INC. | 25,569 | 55,000 | 0.18% | ||
| 22 | NORTHERN TRUST CORP | 19,125 | 41,000 | 0.13% | ||
| 23 | NatWest Group plc | 13,941 | 30,000 | 0.10% | ||
| 24 | UBS AG | 11,652 | 25,000 | 0.08% | ||
| 25 | GABELLI FUNDS LLC | 11,500 | 25,000 | 0.08% | ||
| 26 | Tower Research Capital LLC (TRC) | 6,271 | 13,000 | 0.04% | ||
| 27 | CITIGROUP INC | 3,001 | 7,000 | 0.02% | ||
| 28 | DIMENSIONAL FUND ADVISORS LP | 2,878 | 6,000 | 0.02% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 2,000 | 4,000 | 0.01% | ||
| 30 | Creative Planning | 500 | 1,000 | 0.00% | ||
| 31 | CapWealth Advisors, LLC | 500 | 1,000 | 0.00% | ||
| 32 | AMERIPRISE FINANCIAL INC | 240 | 1,000 | 0.00% | ||
| 33 | WELLS FARGO & COMPANY/MN | 1 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
