| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 10,484,299 | 68,148,000 | 10.97% | ||
| 2 | FMR LLC | 6,911,881 | 44,927,000 | 7.23% | ||
| 3 | PFM Health Sciences, LP | 5,129,129 | 33,339,000 | 5.36% | ||
| 4 | BlackRock Fund Advisors | 4,322,696 | 28,098,000 | 4.52% | ||
| 5 | STATE STREET CORP | 4,238,990 | 27,557,000 | 4.43% | ||
| 6 | FIRST MANHATTAN CO. LLC. | 4,210,055 | 27,365,000 | 4.40% | ||
| 7 | FRANKLIN RESOURCES INC | 4,027,977 | 26,182,000 | 4.21% | ||
| 8 | BANK OF AMERICA CORP /DE/ | 3,333,731 | 21,670,000 | 3.49% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,978,030 | 19,357,000 | 3.11% | ||
| 10 | VANGUARD GROUP INC | 2,957,081 | 19,221,000 | 3.09% | ||
| 11 | FARALLON CAPITAL MANAGEMENT LLC | 2,684,300 | 17,448,000 | 2.81% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,634,512 | 17,124,000 | 2.76% | ||
| 13 | RS INVESTMENT MANAGEMENT CO LLC | 2,223,585 | 14,453,000 | 2.33% | ||
| 14 | FIL Ltd | 2,206,701 | 14,344,000 | 2.31% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 2,049,572 | 13,322,000 | 2.14% | ||
| 16 | NEA Management Company, LLC | 1,935,300 | 12,579,000 | 2.02% | ||
| 17 | DEUTSCHE BANK AG\ | 1,790,586 | 11,637,000 | 1.87% | ||
| 18 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,786,547 | 11,613,000 | 1.87% | ||
| 19 | FRED ALGER MANAGEMENT, LLC | 1,779,759 | 11,568,000 | 1.86% | ||
| 20 | Palo Alto Investors LP | 1,669,024 | 10,849,000 | 1.75% | ||
| 21 | NORTHERN TRUST CORP | 1,388,009 | 9,022,000 | 1.45% | ||
| 22 | QVT Financial LP | 1,322,729 | 8,598,000 | 1.38% | ||
| 23 | Foresite Capital Management I, LLC | 1,250,000 | 8,125,000 | 1.31% | ||
| 24 | STIFEL FINANCIAL CORP | 996,424 | 6,477,000 | 1.04% | ||
| 25 | Hudson Bay Capital Management LP | 947,355 | 6,158,000 | 0.99% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 862,500 | 5,606,000 | 0.90% | Put | |
| 27 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 855,004 | 5,557,000 | 0.89% | ||
| 28 | Rock Springs Capital Management LP | 830,000 | 5,395,000 | 0.87% | ||
| 29 | I.G. INVESTMENT MANAGEMENT, LTD. | 786,000 | 5,109,000 | 0.82% | ||
| 30 | D. E. Shaw & Co., Inc. | 721,088 | 4,687,000 | 0.75% | ||
| 31 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 4,550,000 | 0.73% | ||
| 32 | TEACHERS ADVISORS, LLC | 690,952 | 4,491,000 | 0.72% | ||
| 33 | SAC Capital Advisors LP | 676,800 | 4,399,000 | 0.71% | ||
| 34 | Bank of New York Mellon Corp | 581,032 | 3,777,000 | 0.61% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 580,448 | 3,773,000 | 0.61% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 558,154 | 3,628,000 | 0.58% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 532,942 | 3,464,000 | 0.56% | ||
| 38 | CITIGROUP INC | 528,936 | 3,438,000 | 0.55% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 507,497 | 3,299,000 | 0.53% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 480,500 | 3,123,000 | 0.50% | Call | |
| 41 | Allianz Asset Management GmbH | 462,888 | 3,009,000 | 0.48% | ||
| 42 | ESSEX INVESTMENT MANAGEMENT CO LLC | 433,657 | 2,819,000 | 0.45% | ||
| 43 | GUGGENHEIM CAPITAL LLC | 399,213 | 2,595,000 | 0.42% | ||
| 44 | DRIEHAUS CAPITAL MANAGEMENT LLC | 384,279 | 2,498,000 | 0.40% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 415,647 | 2,377,000 | 0.38% | ||
| 46 | WHITEBOX ADVISORS LLC | 364,992 | 2,372,000 | 0.38% | ||
| 47 | JPMORGAN CHASE & CO | 340,901 | 2,216,000 | 0.36% | ||
| 48 | Forward Management, LLC | 355,056 | 2,181,000 | 0.35% | ||
| 49 | Rhenman & Partners Asset Management AB | 329,199 | 2,140,000 | 0.34% | ||
| 50 | MILLENNIUM MANAGEMENT LLC | 308,300 | 2,004,000 | 0.32% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
