| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 9,921,581 | 61,315,000 | 10.30% | ||
| 2 | Capital Research Global Investors | 9,659,299 | 59,694,000 | 10.03% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,786,400 | 29,580,000 | 4.97% | ||
| 4 | PFM Health Sciences, LP | 4,604,958 | 28,459,000 | 4.78% | ||
| 5 | BlackRock Fund Advisors | 4,240,589 | 26,207,000 | 4.40% | ||
| 6 | STATE STREET CORP | 4,139,892 | 25,586,000 | 4.30% | ||
| 7 | FRANKLIN RESOURCES INC | 3,651,477 | 22,566,000 | 3.79% | ||
| 8 | BANK OF AMERICA CORP /DE/ | 3,158,256 | 19,518,000 | 3.28% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,152,803 | 19,484,000 | 3.27% | ||
| 10 | VANGUARD GROUP INC | 2,992,272 | 18,493,000 | 3.11% | ||
| 11 | FIRST MANHATTAN CO. LLC. | 2,810,055 | 17,366,000 | 2.92% | ||
| 12 | FARALLON CAPITAL MANAGEMENT LLC | 2,684,300 | 16,589,000 | 2.79% | ||
| 13 | FIL Ltd | 2,259,500 | 13,964,000 | 2.35% | ||
| 14 | RS INVESTMENT MANAGEMENT CO LLC | 2,179,142 | 13,467,000 | 2.26% | ||
| 15 | NEA Management Company, LLC | 1,935,300 | 11,960,000 | 2.01% | ||
| 16 | Palo Alto Investors LP | 1,931,324 | 11,936,000 | 2.01% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,821,547 | 11,257,000 | 1.89% | ||
| 18 | DEUTSCHE BANK AG\ | 1,763,071 | 10,895,000 | 1.83% | ||
| 19 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 1,752,792 | 10,832,000 | 1.82% | ||
| 20 | FRED ALGER MANAGEMENT, LLC | 1,528,031 | 9,443,000 | 1.59% | ||
| 21 | NORTHERN TRUST CORP | 1,381,075 | 8,535,000 | 1.43% | ||
| 22 | Foresite Capital Management I, LLC | 1,250,000 | 7,725,000 | 1.30% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,158,496 | 7,160,000 | 1.20% | ||
| 24 | I.G. INVESTMENT MANAGEMENT, LTD. | 1,090,900 | 6,742,000 | 1.13% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 948,600 | 5,862,000 | 0.99% | Put | |
| 26 | Hudson Bay Capital Management LP | 922,664 | 5,702,000 | 0.96% | ||
| 27 | Rock Springs Capital Management LP | 905,000 | 5,593,000 | 0.94% | ||
| 28 | STIFEL FINANCIAL CORP | 893,830 | 5,524,000 | 0.93% | ||
| 29 | D. E. Shaw & Co., Inc. | 852,313 | 5,267,000 | 0.89% | ||
| 30 | TEACHERS ADVISORS, LLC | 750,479 | 4,638,000 | 0.78% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 737,373 | 4,557,000 | 0.77% | ||
| 32 | CREDIT SUISSE AG/ | 715,171 | 4,419,000 | 0.74% | ||
| 33 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 4,326,000 | 0.73% | ||
| 34 | CQS Cayman LP | 660,040 | 4,079,000 | 0.69% | ||
| 35 | Bank of New York Mellon Corp | 657,532 | 4,064,000 | 0.68% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 642,076 | 3,968,000 | 0.67% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 550,100 | 3,400,000 | 0.57% | Call | |
| 38 | PRINCIPAL FINANCIAL GROUP INC | 500,834 | 3,095,000 | 0.52% | ||
| 39 | CITIGROUP INC | 488,748 | 3,020,000 | 0.51% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 423,161 | 2,615,000 | 0.44% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 383,188 | 2,368,000 | 0.40% | ||
| 42 | DRIEHAUS CAPITAL MANAGEMENT LLC | 374,114 | 2,312,000 | 0.39% | ||
| 43 | Nicholas Investment Partners, LP | 338,496 | 2,092,000 | 0.35% | ||
| 44 | BlackRock Investment Management, LLC | 335,836 | 2,075,000 | 0.35% | ||
| 45 | MILLENNIUM MANAGEMENT LLC | 310,900 | 1,921,000 | 0.32% | Call | |
| 46 | Rhenman & Partners Asset Management AB | 300,199 | 1,855,000 | 0.31% | ||
| 47 | GROUP ONE TRADING LLC | 287,748 | 1,778,000 | 0.30% | ||
| 48 | Clearbridge Investments, LLC | 265,000 | 1,638,000 | 0.28% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 258,915 | 1,601,000 | 0.27% | ||
| 50 | Ghost Tree Capital, LLC | 250,000 | 1,545,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
