| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,894,205 | 85,302,000 | 9.91% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,612,800 | 51,778,000 | 6.01% | ||
| 3 | BlackRock Fund Advisors | 4,985,939 | 39,040,000 | 4.53% | ||
| 4 | STATE STREET CORP | 4,966,182 | 38,886,000 | 4.52% | ||
| 5 | Foresite Capital Management II, LLC | 4,200,047 | 32,886,000 | 3.82% | ||
| 6 | VANGUARD GROUP INC | 3,787,986 | 29,660,000 | 3.45% | ||
| 7 | NEA Management Company, LLC | 3,709,000 | 29,041,000 | 3.37% | ||
| 8 | Capital Research Global Investors | 3,620,000 | 28,345,000 | 3.29% | ||
| 9 | FRANKLIN RESOURCES INC | 3,446,000 | 26,982,000 | 3.13% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,200,101 | 25,057,000 | 2.91% | ||
| 11 | SAMLYN CAPITAL, LLC | 3,138,530 | 24,574,000 | 2.85% | ||
| 12 | MORGAN STANLEY | 2,914,945 | 22,824,000 | 2.65% | ||
| 13 | Scale Management, LLC | 2,884,305 | 22,584,000 | 2.62% | ||
| 14 | PFM Health Sciences, LP | 2,870,492 | 22,476,000 | 2.61% | ||
| 15 | DEUTSCHE BANK AG\ | 2,624,658 | 20,549,000 | 2.39% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 2,247,696 | 17,599,000 | 2.04% | ||
| 17 | Point72 Asset Management, L.P. | 2,048,300 | 16,038,000 | 1.86% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 2,009,810 | 15,737,000 | 1.83% | ||
| 19 | Palo Alto Investors LP | 1,931,324 | 15,122,000 | 1.76% | ||
| 20 | CQS Cayman LP | 1,822,000 | 14,266,000 | 1.66% | ||
| 21 | FIL Ltd | 1,697,014 | 13,287,000 | 1.54% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,679,047 | 13,147,000 | 1.53% | ||
| 23 | Rock Springs Capital Management LP | 1,550,000 | 12,137,000 | 1.41% | ||
| 24 | Cheyne Capital Management (UK) LLP | 1,484,409 | 11,601,000 | 1.35% | ||
| 25 | FARALLON CAPITAL MANAGEMENT LLC | 1,467,000 | 11,487,000 | 1.33% | ||
| 26 | NORTHERN TRUST CORP | 1,378,232 | 10,791,000 | 1.25% | ||
| 27 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 1,292,684 | 10,121,000 | 1.18% | ||
| 28 | Foresite Capital Management I, LLC | 1,229,287 | 9,625,000 | 1.12% | ||
| 29 | RA CAPITAL MANAGEMENT, L.P. | 1,186,229 | 9,288,000 | 1.08% | ||
| 30 | EverPoint Asset Management, LLC | 1,125,000 | 8,809,000 | 1.02% | ||
| 31 | Tamarack Capital Management, LLC | 1,000,000 | 7,830,000 | 0.91% | ||
| 32 | CREDIT SUISSE AG/ | 982,512 | 7,692,000 | 0.89% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 857,102 | 6,711,000 | 0.78% | ||
| 34 | Rhenman & Partners Asset Management AB | 831,800 | 6,513,000 | 0.76% | ||
| 35 | D. E. Shaw & Co., Inc. | 822,562 | 6,441,000 | 0.75% | ||
| 36 | Bank of New York Mellon Corp | 794,302 | 6,219,000 | 0.72% | ||
| 37 | STIFEL FINANCIAL CORP | 759,554 | 5,947,000 | 0.69% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 709,195 | 5,552,000 | 0.64% | ||
| 39 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 5,481,000 | 0.64% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 658,200 | 5,154,000 | 0.60% | Put | |
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 642,873 | 5,034,000 | 0.58% | ||
| 42 | Candriam S.C.A. | 635,000 | 4,973,000 | 0.58% | ||
| 43 | I.G. INVESTMENT MANAGEMENT, LTD. | 589,100 | 4,613,000 | 0.54% | ||
| 44 | Nicholas Investment Partners, LP | 540,830 | 4,235,000 | 0.49% | ||
| 45 | TEACHERS ADVISORS, LLC | 501,357 | 3,926,000 | 0.46% | ||
| 46 | DRW Securities, LLC | 485,600 | 3,802,000 | 0.44% | ||
| 47 | PRINCIPAL FINANCIAL GROUP INC | 480,669 | 3,764,000 | 0.44% | ||
| 48 | Telemetry Investments, L.L.C. | 463,039 | 3,626,000 | 0.42% | ||
| 49 | TWO SIGMA INVESTMENTS, LP | 389,366 | 3,049,000 | 0.35% | ||
| 50 | Spot Trading L.L.C | 374,200 | 2,930,000 | 0.34% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
