| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,613,981 | 64,321,000 | 9.70% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,665,200 | 40,391,000 | 6.09% | ||
| 3 | SAMLYN CAPITAL, LLC | 5,690,722 | 34,486,000 | 5.20% | ||
| 4 | BlackRock Fund Advisors | 4,867,002 | 29,494,000 | 4.45% | ||
| 5 | Capital Research Global Investors | 5,605,600 | 29,429,000 | 4.44% | ||
| 6 | STATE STREET CORP | 4,729,345 | 28,660,000 | 4.32% | ||
| 7 | Foresite Capital Management II, LLC | 4,017,666 | 24,347,000 | 3.67% | ||
| 8 | NEA Management Company, LLC | 3,709,000 | 22,477,000 | 3.39% | ||
| 9 | VANGUARD GROUP INC | 3,666,005 | 22,216,000 | 3.35% | ||
| 10 | FRANKLIN RESOURCES INC | 3,575,800 | 21,669,000 | 3.27% | ||
| 11 | PFM Health Sciences, LP | 3,179,762 | 19,269,000 | 2.91% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 3,178,719 | 19,263,000 | 2.91% | ||
| 13 | Scale Management, LLC | 3,017,445 | 18,286,000 | 2.76% | ||
| 14 | DEUTSCHE BANK AG\ | 2,548,737 | 15,445,000 | 2.33% | ||
| 15 | FRED ALGER MANAGEMENT, LLC | 2,430,038 | 14,726,000 | 2.22% | ||
| 16 | MORGAN STANLEY | 2,307,319 | 13,982,000 | 2.11% | ||
| 17 | FARALLON CAPITAL MANAGEMENT LLC | 1,937,000 | 11,738,000 | 1.77% | ||
| 18 | Palo Alto Investors LP | 1,931,324 | 11,704,000 | 1.77% | ||
| 19 | Lamond Capital Partners LLC | 1,891,000 | 11,459,000 | 1.73% | ||
| 20 | BANK OF AMERICA CORP /DE/ | 1,821,440 | 11,038,000 | 1.67% | ||
| 21 | CQS Cayman LP | 1,750,000 | 10,605,000 | 1.60% | ||
| 22 | Rock Springs Capital Management LP | 1,685,000 | 10,211,000 | 1.54% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,661,047 | 10,066,000 | 1.52% | ||
| 24 | STIFEL FINANCIAL CORP | 957,243 | 8,909,000 | 1.34% | ||
| 25 | NORTHERN TRUST CORP | 1,371,232 | 8,310,000 | 1.25% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 1,252,826 | 7,592,000 | 1.15% | ||
| 27 | Foresite Capital Management I, LLC | 1,235,000 | 7,484,000 | 1.13% | ||
| 28 | FIL Ltd | 1,083,041 | 6,563,000 | 0.99% | ||
| 29 | Cheyne Capital Management (UK) LLP | 1,058,656 | 6,421,000 | 0.97% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,045,792 | 6,337,000 | 0.96% | ||
| 31 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 1,037,188 | 6,285,000 | 0.95% | ||
| 32 | I.G. INVESTMENT MANAGEMENT, LTD. | 1,024,500 | 6,208,000 | 0.94% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 945,530 | 5,730,000 | 0.86% | ||
| 34 | JPMORGAN CHASE & CO | 854,431 | 5,178,000 | 0.78% | ||
| 35 | Bank of New York Mellon Corp | 767,292 | 4,650,000 | 0.70% | ||
| 36 | D. E. Shaw & Co., Inc. | 736,821 | 4,465,000 | 0.67% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 728,000 | 4,412,000 | 0.67% | Put | |
| 38 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 4,243,000 | 0.64% | ||
| 39 | GOLDMAN SACHS GROUP INC | 690,894 | 4,187,000 | 0.63% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 683,559 | 4,142,000 | 0.62% | ||
| 41 | CREDIT SUISSE AG/ | 565,295 | 3,425,000 | 0.52% | ||
| 42 | PRINCIPAL FINANCIAL GROUP INC | 483,377 | 2,929,000 | 0.44% | ||
| 43 | Nicholas Investment Partners, LP | 448,729 | 2,719,000 | 0.41% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 452,188 | 2,564,000 | 0.39% | ||
| 45 | TEACHERS ADVISORS, LLC | 406,822 | 2,465,000 | 0.37% | ||
| 46 | Rhenman & Partners Asset Management AB | 375,000 | 2,273,000 | 0.34% | ||
| 47 | BlackRock Investment Management, LLC | 353,763 | 2,144,000 | 0.32% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 339,400 | 2,057,000 | 0.31% | Call | |
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 332,189 | 2,014,000 | 0.30% | ||
| 50 | Telemetry Investments, L.L.C. | 293,100 | 1,776,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
