| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | STATE STREET CORP | 11,780,717 | 24,859,000 | 10.31% | ||
| 2 | FMR LLC | 11,598,705 | 24,473,000 | 10.15% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,491,715 | 13,698,000 | 5.68% | ||
| 4 | SAMLYN CAPITAL, LLC | 6,160,417 | 12,998,000 | 5.39% | ||
| 5 | VANGUARD GROUP INC | 4,599,187 | 9,704,000 | 4.02% | ||
| 6 | BlackRock Fund Advisors | 4,456,432 | 9,403,000 | 3.90% | ||
| 7 | FRANKLIN RESOURCES INC | 4,324,500 | 9,125,000 | 3.78% | ||
| 8 | Foresite Capital Management II, LLC | 4,225,047 | 8,915,000 | 3.70% | ||
| 9 | MORGAN STANLEY | 3,979,635 | 8,396,000 | 3.48% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 3,939,973 | 8,313,000 | 3.45% | ||
| 11 | CREDIT SUISSE AG/ | 3,805,053 | 8,029,000 | 3.33% | ||
| 12 | NEA Management Company, LLC | 3,709,000 | 7,826,000 | 3.25% | ||
| 13 | DEUTSCHE BANK AG\ | 2,882,824 | 6,082,000 | 2.52% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 2,810,298 | 5,930,000 | 2.46% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 2,780,376 | 5,867,000 | 2.43% | ||
| 16 | Palo Alto Investors LP | 1,931,324 | 4,075,000 | 1.69% | ||
| 17 | Rock Springs Capital Management LP | 1,650,000 | 3,482,000 | 1.44% | ||
| 18 | FIL Ltd | 1,586,888 | 3,348,000 | 1.39% | ||
| 19 | Scale Management, LLC | 1,312,575 | 2,770,000 | 1.15% | ||
| 20 | CQS Cayman LP | 1,238,000 | 2,612,000 | 1.08% | ||
| 21 | Foresite Capital Management I, LLC | 1,229,287 | 2,594,000 | 1.08% | ||
| 22 | Cheyne Capital Management (UK) LLP | 1,215,392 | 2,558,000 | 1.06% | ||
| 23 | NORTHERN TRUST CORP | 1,212,630 | 2,558,000 | 1.06% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,208,850 | 2,550,000 | 1.06% | ||
| 25 | Rhenman & Partners Asset Management AB | 1,189,000 | 2,509,000 | 1.04% | ||
| 26 | NEXT CENTURY GROWTH INVESTORS LLC | 1,155,658 | 2,438,000 | 1.01% | ||
| 27 | EcoR1 Capital, LLC | 937,958 | 1,979,000 | 0.82% | ||
| 28 | PRINCIPAL FINANCIAL GROUP INC | 911,812 | 1,924,000 | 0.80% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 903,694 | 1,906,000 | 0.79% | ||
| 30 | GOLDMAN SACHS GROUP INC | 797,541 | 1,682,000 | 0.70% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 740,638 | 1,562,000 | 0.65% | ||
| 32 | BAUPOST GROUP LLC/MA | 821,363 | 1,529,000 | 0.63% | ||
| 33 | I.G. INVESTMENT MANAGEMENT, LTD. | 717,500 | 1,514,000 | 0.63% | ||
| 34 | SILVERBACK ASSET MANAGEMENT LLC | 703,493 | 1,477,000 | 0.61% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 674,224 | 1,423,000 | 0.59% | ||
| 36 | Candriam S.C.A. | 647,000 | 1,365,000 | 0.57% | ||
| 37 | TIVERTON ASSET MANAGEMENT LLC | 600,000 | 1,266,000 | 0.53% | ||
| 38 | WOLVERINE ASSET MANAGEMENT LLC | 4,664 | 1,215,000 | 0.50% | Put | |
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 572,113 | 1,208,000 | 0.50% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 555,492 | 1,172,000 | 0.49% | ||
| 41 | OXFORD ASSET MANAGEMENT LLP | 527,115 | 1,112,000 | 0.46% | ||
| 42 | Bank of New York Mellon Corp | 524,771 | 1,107,000 | 0.46% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 491,859 | 1,038,000 | 0.43% | ||
| 44 | BALYASNY ASSET MANAGEMENT L.P. | 426,000 | 899,000 | 0.37% | Call | |
| 45 | HealthCor Management, L.P. | 425,000 | 897,000 | 0.37% | ||
| 46 | WELLS FARGO & COMPANY/MN | 413,268 | 872,000 | 0.36% | ||
| 47 | GROUP ONE TRADING LLC | 401,124 | 846,000 | 0.35% | ||
| 48 | AMERICAN CENTURY COMPANIES INC | 387,617 | 818,000 | 0.34% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 377,700 | 797,000 | 0.33% | Call | |
| 50 | BlackRock Investment Management, LLC | 371,646 | 784,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
