| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 11,598,705 | 57,414,000 | 10.01% | ||
| 2 | STATE STREET CORP | 7,432,759 | 36,792,000 | 6.41% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,583,700 | 32,589,000 | 5.68% | ||
| 4 | SAMLYN CAPITAL, LLC | 6,046,521 | 29,930,000 | 5.22% | ||
| 5 | PFM Health Sciences, LP | 5,278,672 | 26,129,000 | 4.56% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 4,645,302 | 22,994,000 | 4.01% | ||
| 7 | VANGUARD GROUP INC | 4,522,769 | 22,387,000 | 3.90% | ||
| 8 | BlackRock Fund Advisors | 4,335,679 | 21,462,000 | 3.74% | ||
| 9 | Foresite Capital Management II, LLC | 4,200,047 | 20,790,000 | 3.62% | ||
| 10 | CREDIT SUISSE AG/ | 4,019,639 | 19,898,000 | 3.47% | ||
| 11 | NEA Management Company, LLC | 3,709,000 | 18,360,000 | 3.20% | ||
| 12 | FRANKLIN RESOURCES INC | 3,446,000 | 17,058,000 | 2.97% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 2,903,476 | 14,372,000 | 2.51% | ||
| 14 | MORGAN STANLEY | 2,873,592 | 14,224,000 | 2.48% | ||
| 15 | DEUTSCHE BANK AG\ | 2,869,069 | 14,200,000 | 2.48% | ||
| 16 | FARALLON CAPITAL MANAGEMENT LLC | 2,372,000 | 11,741,000 | 2.05% | ||
| 17 | BANK OF AMERICA CORP /DE/ | 2,071,603 | 10,254,000 | 1.79% | ||
| 18 | Palo Alto Investors LP | 1,931,324 | 9,560,000 | 1.67% | ||
| 19 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,691,547 | 8,373,000 | 1.46% | ||
| 20 | FIL Ltd | 1,663,581 | 8,235,000 | 1.44% | ||
| 21 | Scale Management, LLC | 1,560,775 | 7,726,000 | 1.35% | ||
| 22 | Rock Springs Capital Management LP | 1,550,000 | 7,673,000 | 1.34% | ||
| 23 | Cheyne Capital Management (UK) LLP | 1,484,045 | 7,339,000 | 1.28% | ||
| 24 | NORTHERN TRUST CORP | 1,352,177 | 6,694,000 | 1.17% | ||
| 25 | CQS Cayman LP | 1,350,000 | 6,683,000 | 1.17% | ||
| 26 | Foresite Capital Management I, LLC | 1,229,287 | 6,085,000 | 1.06% | ||
| 27 | NEXT CENTURY GROWTH INVESTORS LLC | 1,105,642 | 5,472,000 | 0.95% | ||
| 28 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 4,950,000 | 0.86% | ||
| 29 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 917,303 | 4,540,000 | 0.79% | ||
| 30 | GOLDMAN SACHS GROUP INC | 828,951 | 4,103,000 | 0.72% | ||
| 31 | I.G. INVESTMENT MANAGEMENT, LTD. | 823,200 | 4,075,000 | 0.71% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 803,188 | 3,976,000 | 0.69% | ||
| 33 | Rhenman & Partners Asset Management AB | 789,000 | 3,906,000 | 0.68% | ||
| 34 | Bank of New York Mellon Corp | 739,855 | 3,662,000 | 0.64% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 710,299 | 3,515,000 | 0.61% | ||
| 36 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 3,465,000 | 0.60% | ||
| 37 | Candriam S.C.A. | 635,000 | 3,143,000 | 0.55% | ||
| 38 | PRINCIPAL FINANCIAL GROUP INC | 532,218 | 2,634,000 | 0.46% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 486,352 | 2,407,000 | 0.42% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 456,406 | 2,260,000 | 0.39% | ||
| 41 | BLACKROCK ADVISORS LLC | 451,824 | 2,237,000 | 0.39% | ||
| 42 | GREAT POINT PARTNERS LLC | 440,000 | 2,178,000 | 0.38% | ||
| 43 | JPMORGAN CHASE & CO | 430,537 | 2,132,000 | 0.37% | ||
| 44 | AMERICAN CENTURY COMPANIES INC | 426,345 | 2,110,000 | 0.37% | ||
| 45 | HealthCor Management, L.P. | 425,000 | 2,104,000 | 0.37% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 421,200 | 2,085,000 | 0.36% | Call | |
| 47 | RENAISSANCE TECHNOLOGIES LLC | 420,400 | 2,081,000 | 0.36% | ||
| 48 | WELLS FARGO & COMPANY/MN | 413,600 | 2,048,000 | 0.36% | ||
| 49 | Nicholas Investment Partners, LP | 409,414 | 2,027,000 | 0.35% | ||
| 50 | BlackRock Investment Management, LLC | 368,690 | 1,825,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
