| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,130,881 | 43,158,000 | 9.68% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,145,200 | 34,699,000 | 7.79% | ||
| 3 | Capital Research Global Investors | 7,895,554 | 33,635,000 | 7.55% | ||
| 4 | PFM Health Sciences, LP | 4,838,324 | 20,611,000 | 4.62% | ||
| 5 | STATE STREET CORP | 4,790,573 | 20,409,000 | 4.58% | ||
| 6 | BlackRock Fund Advisors | 4,442,897 | 18,927,000 | 4.25% | ||
| 7 | FRANKLIN RESOURCES INC | 4,020,877 | 17,129,000 | 3.84% | ||
| 8 | VANGUARD GROUP INC | 3,734,125 | 15,907,000 | 3.57% | ||
| 9 | NEA Management Company, LLC | 3,709,000 | 15,800,000 | 3.55% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,430,294 | 14,613,000 | 3.28% | ||
| 11 | FARALLON CAPITAL MANAGEMENT LLC | 2,684,300 | 11,435,000 | 2.57% | ||
| 12 | BANK OF AMERICA CORP /DE/ | 2,483,469 | 10,580,000 | 2.37% | ||
| 13 | SAMLYN CAPITAL, LLC | 2,299,000 | 9,794,000 | 2.20% | ||
| 14 | RS INVESTMENT MANAGEMENT CO LLC | 2,229,642 | 9,498,000 | 2.13% | ||
| 15 | DEUTSCHE BANK AG\ | 2,122,553 | 9,041,000 | 2.03% | ||
| 16 | Palo Alto Investors LP | 1,931,324 | 8,227,000 | 1.85% | ||
| 17 | CQS Cayman LP | 1,750,000 | 7,455,000 | 1.67% | ||
| 18 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 1,700,371 | 7,243,000 | 1.63% | ||
| 19 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,661,047 | 7,076,000 | 1.59% | ||
| 20 | NORTHERN TRUST CORP | 1,400,288 | 5,965,000 | 1.34% | ||
| 21 | I.G. INVESTMENT MANAGEMENT, LTD. | 1,352,900 | 5,763,000 | 1.29% | ||
| 22 | MORGAN STANLEY | 1,253,935 | 5,342,000 | 1.20% | ||
| 23 | CREDIT SUISSE AG/ | 1,250,572 | 5,328,000 | 1.20% | ||
| 24 | Rock Springs Capital Management LP | 1,250,000 | 5,325,000 | 1.19% | ||
| 25 | Foresite Capital Management I, LLC | 1,235,000 | 5,261,000 | 1.18% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,169,200 | 4,981,000 | 1.12% | Put | |
| 27 | FRED ALGER MANAGEMENT, LLC | 1,127,753 | 4,804,000 | 1.08% | ||
| 28 | FIL Ltd | 1,083,041 | 4,614,000 | 1.04% | ||
| 29 | GOLDMAN SACHS GROUP INC | 1,055,487 | 4,496,000 | 1.01% | ||
| 30 | D. E. Shaw & Co., Inc. | 1,017,360 | 4,334,000 | 0.97% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 834,138 | 3,554,000 | 0.80% | ||
| 32 | STIFEL FINANCIAL CORP | 753,915 | 3,211,000 | 0.72% | ||
| 33 | Bank of New York Mellon Corp | 745,616 | 3,177,000 | 0.71% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 730,721 | 3,113,000 | 0.70% | ||
| 35 | TIVERTON ASSET MANAGEMENT LLC | 700,000 | 2,980,000 | 0.67% | ||
| 36 | Cheyne Capital Management (UK) LLP | 693,642 | 2,958,000 | 0.66% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 652,330 | 2,778,000 | 0.62% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 525,900 | 2,241,000 | 0.50% | Call | |
| 39 | PRINCIPAL FINANCIAL GROUP INC | 518,668 | 2,209,000 | 0.50% | ||
| 40 | Nicholas Investment Partners, LP | 500,860 | 2,134,000 | 0.48% | ||
| 41 | Rhenman & Partners Asset Management AB | 494,000 | 2,104,000 | 0.47% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 489,632 | 2,086,000 | 0.47% | ||
| 43 | CITIGROUP INC | 455,632 | 1,941,000 | 0.44% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 452,188 | 1,926,000 | 0.43% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 447,268 | 1,905,000 | 0.43% | ||
| 46 | SILVERBACK ASSET MANAGEMENT LLC | 392,126 | 1,670,000 | 0.37% | ||
| 47 | BlackRock Investment Management, LLC | 358,731 | 1,528,000 | 0.34% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 354,319 | 1,510,000 | 0.34% | ||
| 49 | CREDIT SUISSE AG/ | 300,000 | 1,278,000 | 0.29% | Call | |
| 50 | TD ASSET MANAGEMENT INC | 295,900 | 1,261,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
