| 1 |
Broadfin Capital, LLC |
3,045,306 |
13,399,000 |
22.25% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
1,761,044 |
7,749,000 |
12.87% |
|
|
| 3 |
Opaleye Management Inc. |
1,557,700 |
6,854,000 |
11.38% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,250,000 |
5,500,000 |
9.13% |
|
|
| 5 |
QVT Financial LP |
867,608 |
3,817,000 |
6.34% |
|
|
| 6 |
VANGUARD GROUP INC |
817,524 |
3,597,000 |
5.97% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
765,000 |
3,366,000 |
5.59% |
|
|
| 8 |
PRICE T ROWE ASSOCIATES INC /MD/ |
765,000 |
3,366,000 |
5.59% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
587,563 |
2,585,000 |
4.29% |
|
|
| 10 |
BlackRock Fund Advisors |
564,359 |
2,483,000 |
4.12% |
|
|
| 11 |
STATE STREET CORP |
257,000 |
1,129,000 |
1.87% |
|
|
| 12 |
NORTHERN TRUST CORP |
248,307 |
1,093,000 |
1.82% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
178,743 |
786,000 |
1.31% |
|
|
| 14 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
119,000 |
524,000 |
0.87% |
|
|
| 15 |
LPL Financial LLC |
88,568 |
429,000 |
0.71% |
|
|
| 16 |
Bank of New York Mellon Corp |
95,226 |
419,000 |
0.70% |
|
|
| 17 |
BlackRock Investment Management, LLC |
68,530 |
302,000 |
0.50% |
|
|
| 18 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
61,780 |
272,000 |
0.45% |
|
|
| 19 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
52,600 |
231,000 |
0.38% |
|
|
| 20 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
51,000 |
224,000 |
0.37% |
|
|
| 21 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
47,346 |
208,000 |
0.35% |
|
|
| 22 |
ALPS ADVISORS INC |
36,956 |
163,000 |
0.27% |
|
|
| 23 |
TD ASSET MANAGEMENT INC |
36,500 |
161,000 |
0.27% |
|
|
| 24 |
CARL DOMINO INC |
34,134 |
150,000 |
0.25% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
30,498 |
134,000 |
0.22% |
|
|
| 26 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
23,712 |
105,000 |
0.17% |
|
|
| 27 |
WHITE PINE CAPITAL LLC |
20,000 |
88,000 |
0.15% |
|
|
| 28 |
VAN ECK ASSOCIATES CORP |
19,983 |
88,000 |
0.15% |
|
|
| 29 |
CITIGROUP INC |
19,519 |
86,000 |
0.14% |
|
|
| 30 |
RHUMBLINE ADVISERS |
18,385 |
81,000 |
0.13% |
|
|
| 31 |
TFS CAPITAL LLC |
15,663 |
69,000 |
0.11% |
|
|
| 32 |
NEW YORK STATE COMMON RETIREMENT FUND |
15,500 |
68,000 |
0.11% |
|
|
| 33 |
HYMAN CHARLES D |
15,143 |
67,000 |
0.11% |
|
|
| 34 |
GOLDMAN SACHS GROUP INC |
15,018 |
66,000 |
0.11% |
|
|
| 35 |
WELLS FARGO & COMPANY/MN |
14,504 |
64,000 |
0.11% |
|
|
| 36 |
Nationwide Fund Advisors |
13,698 |
60,000 |
0.10% |
|
|
| 37 |
Raymond James Financial Services Advisors, Inc. |
12,812 |
56,000 |
0.09% |
|
|
| 38 |
CUTLER GROUP LLC / CA |
12,197 |
53,000 |
0.09% |
|
|
| 39 |
Psagot Value Holdings Ltd. |
11,821 |
52,000 |
0.09% |
|
|
| 40 |
BLACKROCK ADVISORS LLC |
10,975 |
48,000 |
0.08% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
9,956 |
43,000 |
0.07% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
7,955 |
35,000 |
0.06% |
|
|
| 43 |
MORGAN STANLEY |
6,772 |
29,000 |
0.05% |
|
|
| 44 |
STRS OHIO |
5,400 |
23,000 |
0.04% |
|
|
| 45 |
PENSERRA CAPITAL MANAGEMENT LLC |
3,544 |
15,000 |
0.02% |
|
|
| 46 |
VICTORY CAPITAL MANAGEMENT INC |
3,174 |
14,000 |
0.02% |
|
|
| 47 |
DEUTSCHE BANK AG\ |
3,341 |
14,000 |
0.02% |
|
|
| 48 |
Creative Planning |
3,000 |
13,000 |
0.02% |
|
|
| 49 |
ROYAL BANK OF CANADA |
2,000 |
9,000 |
0.01% |
|
|
| 50 |
UBS Group AG |
1,750 |
8,000 |
0.01% |
|
|
