| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 3,045,306 | 18,333,000 | 22.49% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,748,112 | 10,524,000 | 12.91% | ||
| 3 | Opaleye Management Inc. | 1,390,000 | 8,368,000 | 10.27% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 900,000 | 5,418,000 | 6.65% | ||
| 5 | QVT Financial LP | 867,608 | 5,223,000 | 6.41% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 765,000 | 4,605,000 | 5.65% | ||
| 7 | BAKER BROS. ADVISORS LP | 765,000 | 4,605,000 | 5.65% | ||
| 8 | VANGUARD GROUP INC | 761,993 | 4,587,000 | 5.63% | ||
| 9 | BlackRock Fund Advisors | 596,347 | 3,590,000 | 4.40% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 590,563 | 3,555,000 | 4.36% | ||
| 11 | BAILLIE GIFFORD & CO | 360,650 | 2,171,000 | 2.66% | ||
| 12 | NORTHERN TRUST CORP | 231,611 | 1,394,000 | 1.71% | ||
| 13 | STATE STREET CORP | 221,504 | 1,336,000 | 1.64% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 181,121 | 1,089,000 | 1.34% | ||
| 15 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 119,000 | 716,000 | 0.88% | ||
| 16 | LPL Financial LLC | 90,268 | 538,000 | 0.66% | ||
| 17 | TIAA CREF INVESTMENT MANAGEMENT LLC | 83,348 | 502,000 | 0.62% | ||
| 18 | Spark Investment Management LLC | 77,400 | 465,000 | 0.57% | ||
| 19 | Bank of New York Mellon Corp | 77,088 | 464,000 | 0.57% | ||
| 20 | BlackRock Investment Management, LLC | 68,251 | 411,000 | 0.50% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 51,000 | 307,000 | 0.38% | ||
| 22 | ALPS ADVISORS INC | 43,290 | 261,000 | 0.32% | ||
| 23 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,100 | 247,000 | 0.30% | ||
| 24 | TD ASSET MANAGEMENT INC | 36,500 | 220,000 | 0.27% | ||
| 25 | CARL DOMINO INC | 34,134 | 205,000 | 0.25% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 32,581 | 196,000 | 0.24% | ||
| 27 | TEACHERS ADVISORS, LLC | 30,498 | 184,000 | 0.23% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,712 | 143,000 | 0.18% | ||
| 29 | Spot Trading L.L.C | 23,600 | 142,000 | 0.17% | Call | |
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,500 | 141,000 | 0.17% | Call | |
| 31 | VAN ECK ASSOCIATES CORP | 19,868 | 120,000 | 0.15% | ||
| 32 | WHITE PINE CAPITAL LLC | 20,000 | 120,000 | 0.15% | ||
| 33 | AQR CAPITAL MANAGEMENT LLC | 18,927 | 114,000 | 0.14% | ||
| 34 | RHUMBLINE ADVISERS | 18,185 | 109,000 | 0.13% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 15,500 | 93,000 | 0.11% | ||
| 36 | HYMAN CHARLES D | 15,143 | 91,000 | 0.11% | ||
| 37 | Psagot Value Holdings Ltd. | 14,933 | 90,000 | 0.11% | ||
| 38 | WELLS FARGO & COMPANY/MN | 14,196 | 85,000 | 0.10% | ||
| 39 | Nationwide Fund Advisors | 13,698 | 82,000 | 0.10% | ||
| 40 | GOLDMAN SACHS GROUP INC | 13,232 | 80,000 | 0.10% | ||
| 41 | CUTLER GROUP LLC / CA | 12,197 | 73,000 | 0.09% | ||
| 42 | ALAMBIC INVESTMENT MANAGEMENT, L.P. | 11,220 | 68,000 | 0.08% | ||
| 43 | BLACKROCK ADVISORS LLC | 10,975 | 66,000 | 0.08% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 9,856 | 59,000 | 0.07% | ||
| 45 | MORGAN STANLEY | 7,256 | 43,000 | 0.05% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,321 | 38,000 | 0.05% | ||
| 47 | STRS OHIO | 5,400 | 32,000 | 0.04% | ||
| 48 | DEUTSCHE BANK AG\ | 5,582 | 32,000 | 0.04% | ||
| 49 | UBS Group AG | 3,713 | 23,000 | 0.03% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 3,537 | 21,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
