| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 3,370,306 | 18,773,000 | 20.47% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,100,000 | 11,697,000 | 12.75% | ||
| 3 | Opaleye Management Inc. | 1,800,000 | 10,026,000 | 10.93% | ||
| 4 | JENNISON ASSOCIATES LLC | 1,715,850 | 9,557,000 | 10.42% | ||
| 5 | VANGUARD GROUP INC | 1,082,300 | 6,028,000 | 6.57% | ||
| 6 | BAKER BROS. ADVISORS LP | 880,539 | 4,905,000 | 5.35% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 763,867 | 4,255,000 | 4.64% | ||
| 8 | BlackRock Fund Advisors | 744,794 | 4,149,000 | 4.52% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 651,233 | 3,627,000 | 3.95% | ||
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 450,000 | 2,507,000 | 2.73% | ||
| 11 | CASDIN CAPITAL, LLC | 375,000 | 2,089,000 | 2.28% | ||
| 12 | STATE STREET CORP | 299,549 | 1,667,000 | 1.82% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 293,460 | 1,635,000 | 1.78% | ||
| 14 | NORTHERN TRUST CORP | 276,919 | 1,543,000 | 1.68% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 200,393 | 1,116,000 | 1.22% | ||
| 16 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 187,500 | 1,044,000 | 1.14% | ||
| 17 | SABBY MANAGEMENT, LLC | 141,977 | 791,000 | 0.86% | ||
| 18 | QVT Financial LP | 123,500 | 688,000 | 0.75% | ||
| 19 | Bank of New York Mellon Corp | 109,048 | 608,000 | 0.66% | ||
| 20 | BlackRock Investment Management, LLC | 98,475 | 549,000 | 0.60% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 81,026 | 451,000 | 0.49% | ||
| 22 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,592 | 321,000 | 0.35% | ||
| 23 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 51,000 | 284,000 | 0.31% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,012 | 246,000 | 0.27% | ||
| 25 | LPL Financial LLC | 40,603 | 223,000 | 0.24% | ||
| 26 | Sunbelt Securities, Inc. | 40,000 | 223,000 | 0.24% | ||
| 27 | TEACHERS ADVISORS, LLC | 39,332 | 219,000 | 0.24% | ||
| 28 | TD ASSET MANAGEMENT INC | 36,500 | 203,000 | 0.22% | ||
| 29 | NORTHERN CAPITAL MANAGEMENT LLC | 35,950 | 200,000 | 0.22% | ||
| 30 | Birchview Capital, LP | 34,000 | 189,000 | 0.21% | ||
| 31 | CARL DOMINO INC | 33,273 | 179,000 | 0.20% | ||
| 32 | RHUMBLINE ADVISERS | 24,818 | 138,000 | 0.15% | ||
| 33 | GOLDMAN SACHS GROUP INC | 23,333 | 130,000 | 0.14% | ||
| 34 | Nationwide Fund Advisors | 20,654 | 115,000 | 0.13% | ||
| 35 | WHITE PINE CAPITAL LLC | 20,000 | 111,000 | 0.12% | ||
| 36 | VAN ECK ASSOCIATES CORP | 15,746 | 88,000 | 0.10% | ||
| 37 | BLACKROCK ADVISORS LLC | 15,665 | 87,000 | 0.09% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 15,500 | 86,000 | 0.09% | ||
| 39 | BOOTHBAY FUND MANAGEMENT, LLC | 15,170 | 84,000 | 0.09% | ||
| 40 | HYMAN CHARLES D | 15,143 | 84,000 | 0.09% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 14,047 | 78,242 | 0.09% | ||
| 42 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,165 | 78,000 | 0.09% | ||
| 43 | WELLS FARGO & COMPANY/MN | 13,345 | 74,000 | 0.08% | ||
| 44 | VOYA INVESTMENT MANAGEMENT LLC | 12,471 | 69,000 | 0.08% | ||
| 45 | OXFORD ASSET MANAGEMENT LLP | 11,267 | 63,000 | 0.07% | ||
| 46 | MORGAN STANLEY | 10,757 | 60,000 | 0.07% | ||
| 47 | CREDIT SUISSE AG/ | 10,117 | 56,000 | 0.06% | ||
| 48 | CUTLER GROUP LLC / CA | 6,614 | 36,000 | 0.04% | ||
| 49 | Psagot Value Holdings Ltd. | 6,020 | 34,000 | 0.04% | ||
| 50 | Creative Planning | 5,000 | 28,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
