| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 6,574,060 | 78,954,000 | 27.18% | ||
| 2 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,830,473 | 21,984,000 | 7.57% | ||
| 3 | Foresite Capital Management I, LLC | 1,379,080 | 16,563,000 | 5.70% | ||
| 4 | WELLS FARGO & COMPANY/MN | 1,334,341 | 16,025,000 | 5.52% | ||
| 5 | BlackRock Fund Advisors | 1,175,245 | 14,115,000 | 4.86% | ||
| 6 | FRANKLIN RESOURCES INC | 964,800 | 11,587,000 | 3.99% | ||
| 7 | Granahan Investment Management, LLC | 951,018 | 11,422,000 | 3.93% | ||
| 8 | VANGUARD GROUP INC | 782,566 | 9,399,000 | 3.24% | ||
| 9 | Cormorant Asset Management, LP | 750,000 | 9,008,000 | 3.10% | ||
| 10 | FMR LLC | 707,039 | 8,492,000 | 2.92% | ||
| 11 | AMERIPRISE FINANCIAL INC | 578,682 | 6,950,000 | 2.39% | ||
| 12 | LORD, ABBETT & CO. LLC | 426,208 | 5,119,000 | 1.76% | ||
| 13 | Espalier Global Management LLC | 425,000 | 5,104,000 | 1.76% | ||
| 14 | OppenheimerFunds, Inc. | 371,139 | 4,457,000 | 1.53% | ||
| 15 | WALL STREET ASSOCIATES | 367,200 | 4,410,000 | 1.52% | ||
| 16 | STATE STREET CORP | 342,835 | 4,120,000 | 1.42% | ||
| 17 | WEXFORD CAPITAL LP | 332,896 | 3,998,000 | 1.38% | ||
| 18 | Invesco Ltd. | 331,892 | 3,986,000 | 1.37% | ||
| 19 | NORTHERN TRUST CORP | 300,920 | 3,614,000 | 1.24% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 271,289 | 3,258,000 | 1.12% | ||
| 21 | Independence Capital Asset Partners, LLC | 268,966 | 3,230,000 | 1.11% | ||
| 22 | Allianz Asset Management GmbH | 257,885 | 3,097,000 | 1.07% | ||
| 23 | SOPHROSYNE CAPITAL LLC | 248,976 | 2,990,000 | 1.03% | ||
| 24 | Broadfin Capital, LLC | 200,000 | 2,402,000 | 0.83% | ||
| 25 | AQR CAPITAL MANAGEMENT LLC | 171,655 | 2,062,000 | 0.71% | ||
| 26 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 171,270 | 2,057,000 | 0.71% | ||
| 27 | TFS CAPITAL LLC | 154,140 | 1,851,000 | 0.64% | ||
| 28 | EVENTIDE ASSET MANAGEMENT, LLC | 139,400 | 1,674,000 | 0.58% | ||
| 29 | Bank of New York Mellon Corp | 138,576 | 1,664,000 | 0.57% | ||
| 30 | SHEPHERD KAPLAN KROCHUK, LLC | 136,469 | 1,639,000 | 0.56% | ||
| 31 | JPMORGAN CHASE & CO | 130,000 | 1,561,000 | 0.54% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 123,436 | 1,482,000 | 0.51% | ||
| 33 | Jefferies Group LLC | 113,977 | 1,369,000 | 0.47% | ||
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 104,820 | 1,259,000 | 0.43% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,200 | 1,119,000 | 0.39% | Call | |
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 86,404 | 1,038,000 | 0.36% | ||
| 37 | MYCIO WEALTH PARTNERS, LLC | 75,000 | 901,000 | 0.31% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,739 | 862,000 | 0.30% | ||
| 39 | BlackRock Investment Management, LLC | 64,316 | 772,000 | 0.27% | ||
| 40 | Granite Point Capital Management, L.P. | 61,200 | 735,000 | 0.25% | ||
| 41 | PRICE T ROWE ASSOCIATES INC /MD/ | 59,735 | 717,000 | 0.25% | ||
| 42 | ProShare Advisors LLC | 56,578 | 680,000 | 0.23% | ||
| 43 | TWO SIGMA INVESTMENTS, LP | 49,976 | 600,000 | 0.21% | ||
| 44 | Neuberger Berman Group LLC | 49,375 | 592,000 | 0.20% | ||
| 45 | SABBY MANAGEMENT, LLC | 46,316 | 556,000 | 0.19% | ||
| 46 | CREDIT SUISSE AG/ | 46,130 | 554,000 | 0.19% | ||
| 47 | FORTALEZA ASSET MANAGEMENT INC/ | 43,925 | 528,000 | 0.18% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,295 | 508,000 | 0.17% | ||
| 49 | ELLINGTON MANAGEMENT GROUP LLC | 42,200 | 507,000 | 0.17% | ||
| 50 | SSI INVESTMENT MANAGEMENT LLC | 40,856 | 490,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
