| 1 |
PERCEPTIVE ADVISORS LLC |
6,574,060 |
67,384,000 |
30.15% |
|
|
| 2 |
WELLS FARGO & COMPANY/MN |
1,166,120 |
11,952,000 |
5.35% |
|
|
| 3 |
BlackRock Fund Advisors |
1,115,876 |
11,438,000 |
5.12% |
|
|
| 4 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
1,115,183 |
11,431,000 |
5.11% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
964,800 |
9,889,000 |
4.42% |
|
|
| 6 |
Granahan Investment Management, LLC |
892,023 |
9,143,000 |
4.09% |
|
|
| 7 |
Foresite Capital Management I, LLC |
847,983 |
8,692,000 |
3.89% |
|
|
| 8 |
VANGUARD GROUP INC |
809,648 |
8,299,000 |
3.71% |
|
|
| 9 |
Cormorant Asset Management, LP |
700,000 |
7,175,000 |
3.21% |
|
|
| 10 |
FMR LLC |
663,239 |
6,798,000 |
3.04% |
|
|
| 11 |
AMERIPRISE FINANCIAL INC |
522,482 |
5,355,000 |
2.40% |
|
|
| 12 |
Zurcher Kantonalbank (Zurich Cantonalbank) |
400,000 |
4,100,000 |
1.83% |
|
|
| 13 |
LORD, ABBETT & CO. LLC |
383,396 |
3,930,000 |
1.76% |
|
|
| 14 |
OppenheimerFunds, Inc. |
378,125 |
3,876,000 |
1.73% |
|
|
| 15 |
WALL STREET ASSOCIATES |
367,200 |
3,764,000 |
1.68% |
|
|
| 16 |
STATE STREET CORP |
344,396 |
3,528,000 |
1.58% |
|
|
| 17 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
341,900 |
3,505,000 |
1.57% |
Put |
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
283,458 |
2,905,000 |
1.30% |
|
|
| 19 |
NORTHERN TRUST CORP |
262,748 |
2,693,000 |
1.20% |
|
|
| 20 |
Allianz Asset Management GmbH |
250,336 |
2,566,000 |
1.15% |
|
|
| 21 |
SENZAR ASSET MANAGEMENT, LLC |
195,600 |
2,005,000 |
0.90% |
|
|
| 22 |
Invesco Ltd. |
184,137 |
1,887,000 |
0.84% |
|
|
| 23 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
171,270 |
1,756,000 |
0.79% |
|
|
| 24 |
MORGENS WATERFALL VINTIADIS & CO INC |
150,000 |
1,538,000 |
0.69% |
|
|
| 25 |
Bank of New York Mellon Corp |
139,791 |
1,433,000 |
0.64% |
|
|
| 26 |
EVENTIDE ASSET MANAGEMENT, LLC |
139,400 |
1,429,000 |
0.64% |
|
|
| 27 |
JPMORGAN CHASE & CO |
130,000 |
1,333,000 |
0.60% |
|
|
| 28 |
GEODE CAPITAL MANAGEMENT, LLC |
125,216 |
1,283,000 |
0.57% |
|
|
| 29 |
Espalier Global Management LLC |
125,000 |
1,281,000 |
0.57% |
|
|
| 30 |
SHEPHERD KAPLAN KROCHUK, LLC |
118,390 |
1,213,000 |
0.54% |
|
|
| 31 |
SABBY MANAGEMENT, LLC |
102,900 |
1,055,000 |
0.47% |
|
|
| 32 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
98,000 |
1,005,000 |
0.45% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
97,700 |
1,001,000 |
0.45% |
Call |
|
| 34 |
MILLENNIUM MANAGEMENT LLC |
94,321 |
967,000 |
0.43% |
|
|
| 35 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
93,505 |
958,000 |
0.43% |
|
|
| 36 |
Jefferies Group LLC |
75,781 |
777,000 |
0.35% |
|
|
| 37 |
MYCIO WEALTH PARTNERS, LLC |
75,000 |
769,000 |
0.34% |
|
|
| 38 |
BlackRock Investment Management, LLC |
71,758 |
736,000 |
0.33% |
|
|
| 39 |
AQR CAPITAL MANAGEMENT LLC |
63,455 |
650,000 |
0.29% |
|
|
| 40 |
CREDIT SUISSE AG/ |
58,999 |
605,000 |
0.27% |
|
|
| 41 |
MORGAN STANLEY |
55,404 |
568,000 |
0.25% |
|
|
| 42 |
FORTALEZA ASSET MANAGEMENT INC/ |
55,115 |
565,000 |
0.25% |
|
|
| 43 |
Absolute Return Capital, LLC |
53,087 |
544,000 |
0.24% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
50,224 |
515,000 |
0.23% |
|
|
| 45 |
MOORE CAPITAL MANAGEMENT, LP |
50,000 |
513,000 |
0.23% |
|
|
| 46 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
45,295 |
464,000 |
0.21% |
|
|
| 47 |
MARINER INVESTMENT GROUP LLC |
42,500 |
436,000 |
0.20% |
|
|
| 48 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
40,200 |
413,000 |
0.18% |
|
|
| 49 |
PRICE T ROWE ASSOCIATES INC /MD/ |
38,937 |
399,000 |
0.18% |
|
|
| 50 |
ProShare Advisors LLC |
38,377 |
393,000 |
0.18% |
|
|
