| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 6,574,060 | 25,376,000 | 30.76% | ||
| 2 | Palo Alto Investors LP | 2,135,739 | 8,244,000 | 9.99% | ||
| 3 | FMR LLC | 1,725,253 | 6,659,000 | 8.07% | ||
| 4 | Granahan Investment Management, LLC | 1,527,837 | 5,897,000 | 7.15% | ||
| 5 | BlackRock Fund Advisors | 1,269,538 | 4,900,000 | 5.94% | ||
| 6 | VANGUARD GROUP INC | 1,095,839 | 4,231,000 | 5.13% | ||
| 7 | SENZAR ASSET MANAGEMENT, LLC | 1,040,681 | 4,017,000 | 4.87% | ||
| 8 | Cormorant Asset Management, LP | 850,000 | 3,281,000 | 3.98% | ||
| 9 | MORGAN STANLEY | 604,249 | 2,333,000 | 2.83% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 375,864 | 1,451,000 | 1.76% | ||
| 11 | STATE STREET CORP | 372,915 | 1,439,000 | 1.74% | ||
| 12 | WALL STREET ASSOCIATES | 367,200 | 1,417,000 | 1.72% | ||
| 13 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 320,170 | 1,236,000 | 1.50% | ||
| 14 | DEUTSCHE BANK AG\ | 307,932 | 1,186,000 | 1.44% | ||
| 15 | NORTHERN TRUST CORP | 267,442 | 1,032,000 | 1.25% | ||
| 16 | D. E. Shaw & Co., Inc. | 216,151 | 835,000 | 1.01% | ||
| 17 | SABBY MANAGEMENT, LLC | 208,928 | 806,000 | 0.98% | ||
| 18 | Bank of New York Mellon Corp | 154,388 | 596,000 | 0.72% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 150,177 | 579,000 | 0.70% | ||
| 20 | CREDIT SUISSE AG/ | 137,591 | 531,000 | 0.64% | ||
| 21 | SHEPHERD KAPLAN KROCHUK, LLC | 107,392 | 415,000 | 0.50% | ||
| 22 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 101,300 | 391,000 | 0.47% | ||
| 23 | Opus Point Partners Management, LLC | 99,959 | 386,000 | 0.47% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 86,154 | 333,000 | 0.40% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,900 | 301,000 | 0.36% | Call | |
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,800 | 296,000 | 0.36% | Put | |
| 27 | MYCIO WEALTH PARTNERS, LLC | 75,000 | 290,000 | 0.35% | ||
| 28 | BlackRock Investment Management, LLC | 73,324 | 283,000 | 0.34% | ||
| 29 | Joel Isaacson & Co., LLC | 70,660 | 273,000 | 0.33% | ||
| 30 | MARINER INVESTMENT GROUP LLC | 59,700 | 230,000 | 0.28% | ||
| 31 | UBS Group AG | 58,500 | 226,000 | 0.27% | ||
| 32 | Spark Investment Management LLC | 56,400 | 217,000 | 0.26% | ||
| 33 | DEERE & CO | 52,852 | 204,000 | 0.25% | ||
| 34 | TUDOR INVESTMENT CORP ET AL | 52,600 | 203,000 | 0.25% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,151 | 174,000 | 0.21% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,200 | 156,000 | 0.19% | ||
| 37 | ProShare Advisors LLC | 40,240 | 155,000 | 0.19% | ||
| 38 | Swiss National Bank | 36,100 | 139,000 | 0.17% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,981 | 131,000 | 0.16% | ||
| 40 | TEACHERS ADVISORS, LLC | 34,032 | 131,000 | 0.16% | ||
| 41 | OSTERWEIS CAPITAL MANAGEMENT INC | 25,709 | 99,000 | 0.12% | ||
| 42 | GOLDMAN SACHS GROUP INC | 24,893 | 96,000 | 0.12% | ||
| 43 | RHUMBLINE ADVISERS | 24,852 | 96,000 | 0.12% | ||
| 44 | ALPS ADVISORS INC | 21,808 | 84,000 | 0.10% | ||
| 45 | CAXTON CORP | 21,870 | 84,000 | 0.10% | ||
| 46 | D.A. DAVIDSON & CO. | 21,500 | 82,000 | 0.10% | ||
| 47 | DekaBank Deutsche Girozentrale | 20,500 | 79,000 | 0.10% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,085 | 78,000 | 0.09% | ||
| 49 | Nationwide Fund Advisors | 18,296 | 71,000 | 0.09% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 17,658 | 68,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
