| 1 |
PERCEPTIVE ADVISORS LLC |
6,574,060 |
44,243,000 |
30.83% |
|
|
| 2 |
Palo Alto Investors LP |
2,128,539 |
14,325,000 |
9.98% |
|
|
| 3 |
Granahan Investment Management, LLC |
1,541,984 |
10,378,000 |
7.23% |
|
|
| 4 |
BlackRock Fund Advisors |
1,218,745 |
8,202,000 |
5.72% |
|
|
| 5 |
Cormorant Asset Management, LP |
1,000,000 |
6,730,000 |
4.69% |
|
|
| 6 |
MORGAN STANLEY |
973,857 |
6,554,000 |
4.57% |
|
|
| 7 |
VANGUARD GROUP INC |
973,367 |
6,550,000 |
4.56% |
|
|
| 8 |
FMR LLC |
971,601 |
6,539,000 |
4.56% |
|
|
| 9 |
SENZAR ASSET MANAGEMENT, LLC |
906,781 |
6,103,000 |
4.25% |
|
|
| 10 |
OppenheimerFunds, Inc. |
602,713 |
4,056,000 |
2.83% |
|
|
| 11 |
WALL STREET ASSOCIATES |
367,200 |
2,471,000 |
1.72% |
|
|
| 12 |
STATE STREET CORP |
361,872 |
2,430,000 |
1.69% |
|
|
| 13 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
306,070 |
2,060,000 |
1.44% |
|
|
| 14 |
NORTHERN TRUST CORP |
272,017 |
1,831,000 |
1.28% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
258,792 |
1,742,000 |
1.21% |
|
|
| 16 |
D. E. Shaw & Co., Inc. |
238,312 |
1,604,000 |
1.12% |
|
|
| 17 |
SHEPHERD KAPLAN KROCHUK, LLC |
214,784 |
1,445,000 |
1.01% |
|
|
| 18 |
Bank of New York Mellon Corp |
164,892 |
1,110,000 |
0.77% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
146,902 |
988,000 |
0.69% |
|
|
| 20 |
EVENTIDE ASSET MANAGEMENT, LLC |
139,400 |
938,000 |
0.65% |
|
|
| 21 |
Joel Isaacson & Co., LLC |
135,660 |
913,000 |
0.64% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
127,804 |
860,000 |
0.60% |
|
|
| 23 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
101,300 |
682,000 |
0.48% |
|
|
| 24 |
SPHERA FUNDS MANAGEMENT LTD. |
100,000 |
673,000 |
0.47% |
|
|
| 25 |
Opus Point Partners Management, LLC |
99,959 |
673,000 |
0.47% |
|
|
| 26 |
CREDIT SUISSE AG/ |
94,091 |
633,000 |
0.44% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
86,154 |
580,000 |
0.40% |
|
|
| 28 |
MYCIO WEALTH PARTNERS, LLC |
75,000 |
505,000 |
0.35% |
|
|
| 29 |
BlackRock Investment Management, LLC |
72,861 |
490,000 |
0.34% |
|
|
| 30 |
AMERICAN INTERNATIONAL GROUP, INC. |
71,951 |
484,231 |
0.34% |
|
|
| 31 |
MARINER INVESTMENT GROUP LLC |
69,700 |
469,000 |
0.33% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
63,951 |
430,000 |
0.30% |
|
|
| 33 |
MORGENS WATERFALL VINTIADIS & CO INC |
63,700 |
429,000 |
0.30% |
|
|
| 34 |
DEERE & CO |
58,557 |
394,000 |
0.27% |
|
|
| 35 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
47,100 |
317,000 |
0.22% |
Put |
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
45,751 |
308,000 |
0.21% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
40,200 |
271,000 |
0.19% |
|
|
| 38 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
40,000 |
269,000 |
0.19% |
|
|
| 39 |
Swiss National Bank |
36,100 |
243,000 |
0.17% |
|
|
| 40 |
ProShare Advisors LLC |
34,267 |
231,000 |
0.16% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
34,032 |
229,000 |
0.16% |
|
|
| 42 |
MILLENNIUM MANAGEMENT LLC |
33,800 |
227,000 |
0.16% |
|
|
| 43 |
Trexquant Investment LP |
33,000 |
222,000 |
0.15% |
|
|
| 44 |
A.R.T. Advisors, LLC |
28,223 |
189,000 |
0.13% |
|
|
| 45 |
OSTERWEIS CAPITAL MANAGEMENT INC |
25,709 |
173,000 |
0.12% |
|
|
| 46 |
D.A. DAVIDSON & CO. |
23,500 |
158,000 |
0.11% |
|
|
| 47 |
DekaBank Deutsche Girozentrale |
23,500 |
157,000 |
0.11% |
|
|
| 48 |
STEVENS CAPITAL MANAGEMENT LP |
22,781 |
153,000 |
0.11% |
|
|
| 49 |
RHUMBLINE ADVISERS |
20,152 |
136,000 |
0.09% |
|
|
| 50 |
GOLDMAN SACHS GROUP INC |
19,654 |
132,000 |
0.09% |
|
|
