| 1 |
PERCEPTIVE ADVISORS LLC |
6,574,060 |
36,092,000 |
31.71% |
|
|
| 2 |
Palo Alto Investors LP |
1,622,654 |
8,908,000 |
7.83% |
|
|
| 3 |
Granahan Investment Management, LLC |
1,559,623 |
8,562,000 |
7.52% |
|
|
| 4 |
BlackRock Fund Advisors |
1,127,877 |
6,192,000 |
5.44% |
|
|
| 5 |
Cormorant Asset Management, LP |
1,000,000 |
5,490,000 |
4.82% |
|
|
| 6 |
VANGUARD GROUP INC |
853,624 |
4,687,000 |
4.12% |
|
|
| 7 |
Foresite Capital Management I, LLC |
816,251 |
4,481,000 |
3.94% |
|
|
| 8 |
FMR LLC |
663,239 |
3,641,000 |
3.20% |
|
|
| 9 |
OppenheimerFunds, Inc. |
590,573 |
3,242,000 |
2.85% |
|
|
| 10 |
SENZAR ASSET MANAGEMENT, LLC |
553,892 |
3,041,000 |
2.67% |
|
|
| 11 |
JPMORGAN CHASE & CO |
476,200 |
2,615,000 |
2.30% |
|
|
| 12 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
448,049 |
2,460,000 |
2.16% |
|
|
| 13 |
WALL STREET ASSOCIATES |
367,200 |
2,016,000 |
1.77% |
|
|
| 14 |
STATE STREET CORP |
348,839 |
1,913,000 |
1.68% |
|
|
| 15 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
306,070 |
1,680,000 |
1.48% |
|
|
| 16 |
SPHERA FUNDS MANAGEMENT LTD. |
289,849 |
1,591,000 |
1.40% |
|
|
| 17 |
MORGAN STANLEY |
288,478 |
1,584,000 |
1.39% |
|
|
| 18 |
NORTHERN TRUST CORP |
270,741 |
1,486,000 |
1.31% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
265,891 |
1,460,000 |
1.28% |
|
|
| 20 |
SHEPHERD KAPLAN KROCHUK, LLC |
214,784 |
1,179,000 |
1.04% |
|
|
| 21 |
Bank of New York Mellon Corp |
158,991 |
873,000 |
0.77% |
|
|
| 22 |
MORGENS WATERFALL VINTIADIS & CO INC |
150,000 |
824,000 |
0.72% |
|
|
| 23 |
EVENTIDE ASSET MANAGEMENT, LLC |
139,400 |
765,000 |
0.67% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
134,841 |
740,000 |
0.65% |
|
|
| 25 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
112,665 |
619,000 |
0.54% |
|
|
| 26 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
102,500 |
563,000 |
0.49% |
Put |
|
| 27 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
98,000 |
538,000 |
0.47% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
95,724 |
526,000 |
0.46% |
|
|
| 29 |
JANE STREET GROUP, LLC |
95,006 |
522,000 |
0.46% |
|
|
| 30 |
MYCIO WEALTH PARTNERS, LLC |
75,000 |
412,000 |
0.36% |
|
|
| 31 |
BlackRock Investment Management, LLC |
73,614 |
404,000 |
0.35% |
|
|
| 32 |
MARINER INVESTMENT GROUP LLC |
69,700 |
383,000 |
0.34% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
58,208 |
318,000 |
0.28% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
45,555 |
250,000 |
0.22% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
40,200 |
221,000 |
0.19% |
|
|
| 36 |
PRICE T ROWE ASSOCIATES INC /MD/ |
38,937 |
214,000 |
0.19% |
|
|
| 37 |
TEACHERS ADVISORS, LLC |
34,032 |
187,000 |
0.16% |
|
|
| 38 |
Swiss National Bank |
33,000 |
181,000 |
0.16% |
|
|
| 39 |
ProShare Advisors LLC |
32,193 |
177,000 |
0.16% |
|
|
| 40 |
DEERE & CO |
31,770 |
174,000 |
0.15% |
|
|
| 41 |
CREDIT SUISSE AG/ |
26,700 |
146,000 |
0.13% |
|
|
| 42 |
OSTERWEIS CAPITAL MANAGEMENT INC |
25,709 |
141,000 |
0.12% |
|
|
| 43 |
DekaBank Deutsche Girozentrale |
25,500 |
140,000 |
0.12% |
|
|
| 44 |
Neuberger Berman Group LLC |
24,560 |
135,000 |
0.12% |
|
|
| 45 |
D.A. DAVIDSON & CO. |
23,500 |
129,000 |
0.11% |
|
|
| 46 |
GROUP ONE TRADING LLC |
23,120 |
127,000 |
0.11% |
|
|
| 47 |
Cetera Advisor Networks LLC |
21,700 |
121,000 |
0.11% |
|
|
| 48 |
RHUMBLINE ADVISERS |
19,552 |
107,000 |
0.09% |
|
|
| 49 |
Nationwide Fund Advisors |
19,292 |
106,000 |
0.09% |
|
|
| 50 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
19,005 |
104,000 |
0.09% |
|
|
