| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
5,878,015 |
6,348,000 |
18.92% |
|
|
| 2 |
STONEPINE CAPITAL MANAGEMENT, LLC |
4,615,813 |
4,985,000 |
14.86% |
|
|
| 3 |
Avoro Capital Advisors LLC |
4,034,488 |
4,357,000 |
12.99% |
|
|
| 4 |
ARMISTICE CAPITAL, LLC |
3,200,000 |
3,456,000 |
10.30% |
|
|
| 5 |
Palo Alto Investors LP |
3,013,793 |
3,255,000 |
9.70% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
2,293,675 |
2,477,000 |
7.38% |
|
|
| 7 |
NORTH RUN CAPITAL, LP |
1,730,000 |
1,868,000 |
5.57% |
|
|
| 8 |
VANGUARD GROUP INC |
1,543,079 |
1,667,000 |
4.97% |
|
|
| 9 |
Alyeska Investment Group, L.P. |
1,013,892 |
1,095,000 |
3.26% |
|
|
| 10 |
ACUTA CAPITAL PARTNERS, LLC |
974,318 |
1,052,000 |
3.14% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
813,576 |
879,000 |
2.62% |
|
|
| 12 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
274,269 |
296,000 |
0.88% |
|
|
| 13 |
ORBIMED ADVISORS LLC |
250,000 |
270,000 |
0.80% |
|
|
| 14 |
Parkwood LLC |
228,123 |
246,000 |
0.73% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
161,291 |
174,000 |
0.52% |
|
|
| 16 |
BlackRock Fund Advisors |
155,749 |
168,000 |
0.50% |
|
|
| 17 |
PNC FINANCIAL SERVICES GROUP, INC. |
145,100 |
157,000 |
0.47% |
|
|
| 18 |
Spark Investment Management LLC |
135,400 |
146,000 |
0.44% |
|
|
| 19 |
NORTHERN TRUST CORP |
106,439 |
115,000 |
0.34% |
|
|
| 20 |
Weiss Multi-Strategy Advisers LLC |
85,000 |
92,000 |
0.27% |
|
|
| 21 |
RENAISSANCE TECHNOLOGIES LLC |
59,600 |
64,000 |
0.19% |
|
|
| 22 |
STRS OHIO |
43,569 |
47,000 |
0.14% |
|
|
| 23 |
Livingston Group Asset Management CO (operating as Southport Capital Management) |
37,250 |
40,000 |
0.12% |
|
|
| 24 |
Virtu KCG Holdings LLC |
34,627 |
37,000 |
0.11% |
|
|
| 25 |
MILLENNIUM MANAGEMENT LLC |
34,451 |
37,000 |
0.11% |
|
|
| 26 |
WOLVERINE TRADING LP /BD |
28,524 |
31,000 |
0.09% |
|
|
| 27 |
Bank of New York Mellon Corp |
27,413 |
29,000 |
0.09% |
|
|
| 28 |
INVESTMENT CENTERS OF AMERICA INC |
24,000 |
25,000 |
0.07% |
|
|
| 29 |
TWO SIGMA SECURITIES, LLC |
23,191 |
25,000 |
0.07% |
|
|
| 30 |
GUGGENHEIM CAPITAL LLC |
18,553 |
20,000 |
0.06% |
|
|
| 31 |
CUTLER GROUP LLC / CA |
14,686 |
15,000 |
0.04% |
|
|
| 32 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
12,697 |
14,000 |
0.04% |
|
|
| 33 |
Southeast Asset Advisors, LLC |
10,000 |
11,000 |
0.03% |
|
|
| 34 |
BlackRock Institutional Trust Company, N.A. |
10,303 |
11,000 |
0.03% |
|
|
| 35 |
BlackRock Investment Management, LLC |
8,676 |
9,000 |
0.03% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
7,469 |
8,000 |
0.02% |
|
|
| 37 |
Tower Research Capital LLC (TRC) |
6,469 |
7,000 |
0.02% |
|
|
| 38 |
PRELUDE CAPITAL MANAGEMENT, LLC |
4,300 |
5,000 |
0.01% |
|
|
| 39 |
GROUP ONE TRADING LLC |
5,006 |
5,000 |
0.01% |
|
|
| 40 |
UBS Group AG |
3,728 |
4,000 |
0.01% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,405 |
3,000 |
0.01% |
|
|
| 42 |
JPMORGAN CHASE & CO |
1,100 |
1,000 |
0.00% |
|
|
| 43 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1,000 |
1,000 |
0.00% |
|
|
| 44 |
BANK OF MONTREAL /CAN/ |
500 |
1,000 |
0.00% |
|
|
| 45 |
BNP PARIBAS FINANCIAL MARKETS |
5 |
5 |
0.00% |
|
|
| 46 |
BARCLAYS PLC |
93 |
0 |
0.00% |
|
|
| 47 |
MORGAN STANLEY |
400 |
0 |
0.00% |
|
|
| 48 |
GLOBEFLEX CAPITAL L P |
419 |
0 |
0.00% |
|
|
