| # | % | |||||
|---|---|---|---|---|---|---|
| 51 | AMICUS THERAPEUTICS INC | 10,216 | 5,077,000 | 0.30% | Call | |
| 52 | IONIS PHARMACEUTICALS INC | 1,054 | 5,041,000 | 0.29% | Call | |
| 53 | ACORDA THERAPEUTICS INC | 263,947 | 4,962,000 | 0.29% | ||
| 54 | ALNYLAM PHARMACEUTICALS INC | 1,240 | 4,643,000 | 0.27% | Call | |
| 55 | SYNERGY PHARMACEUTICALS DEL | 7,536 | 4,589,000 | 0.27% | Call | |
| 56 | RADIUS HEALTH INC | 1,190 | 4,526,000 | 0.26% | Put | |
| 57 | HORIZON PHARMA PLC | 2,791 | 4,516,000 | 0.26% | Put | |
| 58 | NEUROCRINE BIOSCIENCES INC | 1,153 | 4,462,000 | 0.26% | Call | |
| 59 | AMGEN INC | 301 | 4,401,000 | 0.26% | Call | |
| 60 | SAGE THERAPEUTICS INC | 849 | 4,335,000 | 0.25% | Call | |
| 61 | ACHILLION PHARMACEUTICALS INC | 10,087 | 4,166,000 | 0.24% | Call | |
| 62 | PORTOLA PHARMACEUTICALS INC | 1,803 | 4,046,000 | 0.24% | Call | |
| 63 | MEDICINES CO | 1,172 | 3,978,000 | 0.23% | Put | |
| 64 | APPLIED DNA | 2,109,601 | 3,903,000 | 0.23% | ||
| 65 | STEMLINE THERAPEUTICS INC | 357,806 | 3,829,000 | 0.22% | ||
| 66 | MEDICINES CO | 112,392 | 3,815,000 | 0.22% | ||
| 67 | AMARIN CORP PLC | 12,346 | 3,803,000 | 0.22% | Call | |
| 68 | UNITED THERAPEUTICS CORP | 263 | 3,772,000 | 0.22% | Call | |
| 69 | LA JOLLA PHARMACEUTICAL CO | 210,978 | 3,698,000 | 0.22% | ||
| 70 | BLUEBIRD BIO INC | 597 | 3,665,000 | 0.21% | Call | |
| 71 | IONIS PHARMACEUTICALS INC | 737 | 3,525,000 | 0.21% | Put | |
| 72 | MONSANTO CO NEW | 313 | 3,293,000 | 0.19% | Call | |
| 73 | AXOVANT SCIENCES LTD | 2,638 | 3,276,000 | 0.19% | Put | |
| 74 | BIOGEN INC | 115 | 3,261,000 | 0.19% | Call | |
| 75 | PUMA BIOTECHNOLOGY | 103,243 | 3,170,000 | 0.18% | ||
| 76 | CIDARA THERAPEUTICS INC | 292,398 | 3,041,000 | 0.18% | ||
| 77 | TENAX THERAPEUTICS INC | 1,516,835 | 2,958,000 | 0.17% | ||
| 78 | LA JOLLA PHARMACEUTICAL CO | 1,687 | 2,957,000 | 0.17% | Call | |
| 79 | INTEC PHARMA LTD JERUSALEM | 514,100 | 2,930,000 | 0.17% | ||
| 80 | BIOGEN INC | 100 | 2,836,000 | 0.16% | Put | |
| 81 | EIGER BIOPHARMACEUTICALS INC | 240,541 | 2,802,000 | 0.16% | ||
| 82 | INTRA-CELLULAR THERAPIES INC | 1,781 | 2,688,000 | 0.16% | Call | |
| 83 | HALOZYME THERAPEUTICS INC | 2,708 | 2,676,000 | 0.16% | Call | |
| 84 | EXELIXIS INC | 1,783 | 2,658,000 | 0.15% | Call | |
| 85 | GW PHARMACEUTICALS PLC | 234 | 2,615,000 | 0.15% | Call | |
| 86 | COHERUS BIOSCIENCES INC | 912 | 2,567,000 | 0.15% | Put | |
| 87 | FIBROGEN INC | 1,189 | 2,544,000 | 0.15% | Call | |
| 88 | INSMED INC | 1,913 | 2,531,000 | 0.15% | Put | |
| 89 | CYTORI THERAPEUTICS INC | 1,651,835 | 2,494,000 | 0.15% | ||
| 90 | PROTHENA CORPORATION PLC | 490 | 2,410,000 | 0.14% | Call | |
| 91 | TENAX THERAPEUTICS INC | 12,237 | 2,386,000 | 0.14% | Call | |
| 92 | SYNTHETIC BIOLOGICS INCORPORATED | 3,031,953 | 2,312,000 | 0.13% | ||
| 93 | AGIOS PHARMACEUTICALS INC | 545 | 2,274,000 | 0.13% | Call | |
| 94 | PACIRA PHARMACEUTICALS INC | 700 | 2,261,000 | 0.13% | Call | |
| 95 | VERTEX PHARMACEUTICALS INC | 296 | 2,181,000 | 0.13% | Put | |
| 96 | ENDO INTL PLC | 1,323 | 2,179,000 | 0.13% | Put | |
| 97 | LEXICON PHARMACEUTICALS INC | 1,563 | 2,162,000 | 0.13% | Call | |
| 98 | GW PHARMACEUTICALS PLC | 192 | 2,146,000 | 0.12% | Put | |
| 99 | OPKO HEALTH INC | 2,275 | 2,116,000 | 0.12% | Put | |
| 100 | ENDO INTL PLC | 126,139 | 2,078,000 | 0.12% |
Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-17-008083, filed 2017.02.14).
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
