| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,475,435 | 15,787,000 | 15.06% | ||
| 2 | FRANKLIN RESOURCES INC | 1,449,073 | 15,505,000 | 14.79% | ||
| 3 | EVENTIDE ASSET MANAGEMENT, LLC | 851,400 | 9,110,000 | 8.69% | ||
| 4 | VANGUARD GROUP INC | 620,925 | 6,644,000 | 6.34% | ||
| 5 | BlackRock Fund Advisors | 556,567 | 5,955,000 | 5.68% | ||
| 6 | SABBY MANAGEMENT, LLC | 357,806 | 3,829,000 | 3.65% | ||
| 7 | BAKER BROS. ADVISORS LP | 333,497 | 3,568,000 | 3.40% | ||
| 8 | VHCP MANAGEMENT II, LLC | 315,980 | 3,381,000 | 3.23% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 276,656 | 2,960,000 | 2.82% | ||
| 10 | FARALLON CAPITAL MANAGEMENT LLC | 257,500 | 2,755,000 | 2.63% | ||
| 11 | STATE STREET CORP | 251,804 | 2,694,000 | 2.57% | ||
| 12 | Candriam S.C.A. | 244,000 | 2,611,000 | 2.49% | ||
| 13 | NORTHERN TRUST CORP | 203,831 | 2,181,000 | 2.08% | ||
| 14 | J. Goldman & Co LP | 199,886 | 2,139,000 | 2.04% | ||
| 15 | DEUTSCHE BANK AG\ | 171,848 | 1,837,000 | 1.75% | ||
| 16 | Invesco Ltd. | 169,058 | 1,809,000 | 1.73% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 164,302 | 1,758,000 | 1.68% | ||
| 18 | VHCP Management, LLC | 135,420 | 1,449,000 | 1.38% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 132,891 | 1,421,000 | 1.36% | ||
| 20 | BAILARD, INC. | 123,785 | 1,324,000 | 1.26% | ||
| 21 | COLUMBUS CIRCLE INVESTORS | 97,629 | 1,045,000 | 1.00% | ||
| 22 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 94,945 | 1,015,000 | 0.97% | ||
| 23 | DIMENSIONAL FUND ADVISORS LP | 79,719 | 853,000 | 0.81% | ||
| 24 | BlackRock Investment Management, LLC | 73,870 | 790,000 | 0.75% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,922 | 737,000 | 0.70% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 65,500 | 701,000 | 0.67% | ||
| 27 | Bank of New York Mellon Corp | 64,014 | 685,000 | 0.65% | ||
| 28 | Compagnie Lombard Odier SCmA | 60,500 | 647,000 | 0.62% | ||
| 29 | ACADIAN ASSET MANAGEMENT LLC | 59,756 | 640,000 | 0.61% | ||
| 30 | PANAGORA ASSET MANAGEMENT INC | 55,506 | 594,000 | 0.57% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 54,311 | 581,000 | 0.55% | ||
| 32 | MORGAN STANLEY | 49,781 | 533,000 | 0.51% | ||
| 33 | AMERIPRISE FINANCIAL INC | 40,400 | 433,000 | 0.41% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 40,298 | 431,000 | 0.41% | ||
| 35 | TEACHERS ADVISORS, LLC | 35,195 | 377,000 | 0.36% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,749 | 372,000 | 0.35% | ||
| 37 | OAK RIDGE INVESTMENTS LLC | 34,153 | 365,000 | 0.35% | ||
| 38 | STONERIDGE INVESTMENT PARTNERS LLC | 33,725 | 361,000 | 0.34% | ||
| 39 | D. E. Shaw & Co., Inc. | 31,257 | 334,000 | 0.32% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 31,200 | 334,000 | 0.32% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 31,100 | 333,000 | 0.32% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,300 | 314,000 | 0.30% | Put | |
| 43 | COLUMBUS CIRCLE INVESTORS | 28,900 | 309,000 | 0.29% | Call | |
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,000 | 279,000 | 0.27% | ||
| 45 | CARL DOMINO INC | 26,000 | 278,000 | 0.27% | ||
| 46 | JPMORGAN CHASE & CO | 25,121 | 269,000 | 0.26% | ||
| 47 | Telemetry Investments, L.L.C. | 25,016 | 268,000 | 0.26% | ||
| 48 | JACOBS LEVY EQUITY MANAGEMENT, INC | 24,954 | 267,000 | 0.25% | ||
| 49 | PARADIGM ASSET MANAGEMENT CO LLC | 22,800 | 243,960 | 0.23% | ||
| 50 | RHUMBLINE ADVISERS | 19,231 | 206,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
