| 1 |
VIVO CAPITAL, LLC |
1,787,091 |
20,820,000 |
29.58% |
|
|
| 2 |
INTERWEST VENTURE MANAGEMENT CO |
1,599,592 |
18,635,000 |
26.47% |
|
|
| 3 |
SPHERA FUNDS MANAGEMENT LTD. |
385,301 |
4,489,000 |
6.38% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
354,200 |
4,126,000 |
5.86% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
277,589 |
3,234,000 |
4.59% |
|
|
| 6 |
NEXTHERA CAPITAL LP |
263,600 |
3,071,000 |
4.36% |
|
|
| 7 |
SABBY MANAGEMENT, LLC |
240,541 |
2,802,000 |
3.98% |
|
|
| 8 |
Lombard Odier Asset Management (USA) Corp |
170,032 |
1,981,000 |
2.81% |
|
|
| 9 |
PERCEPTIVE ADVISORS LLC |
157,679 |
1,836,000 |
2.61% |
|
|
| 10 |
VANGUARD GROUP INC |
145,803 |
1,698,000 |
2.41% |
|
|
| 11 |
BOXER CAPITAL, LLC |
138,331 |
1,612,000 |
2.29% |
|
|
| 12 |
BlackRock Fund Advisors |
131,008 |
1,526,000 |
2.17% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
41,254 |
481,000 |
0.68% |
|
|
| 14 |
DEUTSCHE BANK AG\ |
40,901 |
474,000 |
0.67% |
|
|
| 15 |
DAFNA Capital Management LLC |
40,192 |
468,000 |
0.66% |
|
|
| 16 |
NORTHERN TRUST CORP |
38,011 |
443,000 |
0.63% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
35,665 |
416,000 |
0.59% |
|
|
| 18 |
MONASHEE INVESTMENT MANAGEMENT LLC |
31,500 |
367,000 |
0.52% |
|
|
| 19 |
STATE STREET CORP |
30,500 |
356,000 |
0.51% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
26,778 |
311,000 |
0.44% |
|
|
| 21 |
Bank of New York Mellon Corp |
13,082 |
152,000 |
0.22% |
|
|
| 22 |
BlackRock Investment Management, LLC |
12,606 |
147,000 |
0.21% |
|
|
| 23 |
MORGAN STANLEY |
12,133 |
141,000 |
0.20% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
10,513 |
122,000 |
0.17% |
|
|
| 25 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
10,000 |
117,000 |
0.17% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,562 |
100,000 |
0.14% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
5,474 |
64,000 |
0.09% |
|
|
| 28 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,400 |
63,000 |
0.09% |
|
|
| 29 |
RUSSELL INVESTMENTS GROUP, LTD. |
5,498 |
60,000 |
0.09% |
|
|
| 30 |
JPMORGAN CHASE & CO |
3,775 |
44,000 |
0.06% |
|
|
| 31 |
BELLEVUE GROUP AG |
3,333 |
39,000 |
0.06% |
|
|
| 32 |
WELLS FARGO & COMPANY/MN |
3,000 |
35,000 |
0.05% |
|
|
| 33 |
BLACKROCK ADVISORS LLC |
2,473 |
29,000 |
0.04% |
|
|
| 34 |
Nationwide Fund Advisors |
2,082 |
24,000 |
0.03% |
|
|
| 35 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,990 |
23,000 |
0.03% |
|
|
| 36 |
CUTLER GROUP LLC / CA |
1,126 |
13,000 |
0.02% |
|
|
| 37 |
STRS OHIO |
1,200 |
13,000 |
0.02% |
|
|
| 38 |
Legal & General Group Plc |
915 |
10,000 |
0.01% |
|
|
| 39 |
UBS Group AG |
843 |
10,000 |
0.01% |
|
|
| 40 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
650 |
8,000 |
0.01% |
|
|
| 41 |
BANK OF AMERICA CORP /DE/ |
572 |
7,000 |
0.01% |
|
|
| 42 |
MEEDER ASSET MANAGEMENT INC |
568 |
7,000 |
0.01% |
|
|
| 43 |
QUADRANT CAPITAL GROUP LLC |
428 |
4,000 |
0.01% |
|
|
| 44 |
ROYAL BANK OF CANADA |
321 |
4,000 |
0.01% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
326 |
4,000 |
0.01% |
|
|
| 46 |
CITIGROUP INC |
136 |
2,000 |
0.00% |
|
|
| 47 |
BlackRock Finance, Inc. |
150 |
2,000 |
0.00% |
|
|
| 48 |
MSI Financial Services Inc |
133 |
2,000 |
0.00% |
|
|
| 49 |
BANK OF MONTREAL /CAN/ |
101 |
1,000 |
0.00% |
|
|
| 50 |
BNP PARIBAS FINANCIAL MARKETS |
57 |
664 |
0.00% |
|
|
