| 1 |
PHARMSTANDARD INTERNATIONAL S.A. |
13,242,279 |
64,887,000 |
49.60% |
|
|
| 2 |
PHARMSTANDARD INTERNATIONAL S.A. |
5,120,604 |
27,390,000 |
20.94% |
Call |
|
| 3 |
WASATCH ADVISORS LP |
3,254,211 |
15,946,000 |
12.19% |
|
|
| 4 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
1,024,428 |
5,020,000 |
3.84% |
|
|
| 5 |
VANGUARD GROUP INC |
782,336 |
3,834,000 |
2.93% |
|
|
| 6 |
BlackRock Fund Advisors |
455,673 |
2,233,000 |
1.71% |
|
|
| 7 |
SANDERS MORRIS HARRIS INC/FA |
292,512 |
1,433,000 |
1.10% |
|
|
| 8 |
Alyeska Investment Group, L.P. |
200,000 |
980,000 |
0.75% |
Call |
|
| 9 |
STATE STREET CORP |
177,494 |
870,000 |
0.66% |
|
|
| 10 |
ALTRINSIC GLOBAL ADVISORS LLC |
172,505 |
845,000 |
0.65% |
|
|
| 11 |
GEODE CAPITAL MANAGEMENT, LLC |
153,065 |
750,000 |
0.57% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
149,302 |
732,000 |
0.56% |
|
|
| 13 |
NORTHERN TRUST CORP |
146,311 |
717,000 |
0.55% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
143,113 |
701,000 |
0.54% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
121,524 |
595,000 |
0.45% |
|
|
| 16 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
94,800 |
465,000 |
0.36% |
|
|
| 17 |
WALL STREET ASSOCIATES |
82,850 |
406,000 |
0.31% |
|
|
| 18 |
BlackRock Investment Management, LLC |
66,859 |
328,000 |
0.25% |
|
|
| 19 |
Bank of New York Mellon Corp |
59,412 |
291,000 |
0.22% |
|
|
| 20 |
MORGAN STANLEY |
51,285 |
251,000 |
0.19% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
44,657 |
219,000 |
0.17% |
|
|
| 22 |
D. E. Shaw & Co., Inc. |
39,900 |
196,000 |
0.15% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
37,400 |
183,000 |
0.14% |
Put |
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
29,661 |
145,000 |
0.11% |
|
|
| 25 |
HighTower Advisors, LLC |
26,571 |
130,000 |
0.10% |
|
|
| 26 |
KEYBANK NATIONAL ASSOCIATION/OH |
24,358 |
119,000 |
0.09% |
|
|
| 27 |
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
77,906 |
115,000 |
0.09% |
|
|
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
22,200 |
109,000 |
0.08% |
|
|
| 29 |
CITADEL ADVISORS LLC |
20,600 |
101,000 |
0.08% |
Call |
|
| 30 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
17,800 |
87,000 |
0.07% |
Call |
|
| 31 |
TEACHERS ADVISORS, LLC |
16,307 |
80,000 |
0.06% |
|
|
| 32 |
CITIGROUP INC |
14,510 |
71,000 |
0.05% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
13,399 |
66,000 |
0.05% |
|
|
| 34 |
ADVISOR GROUP, INC. |
13,500 |
66,000 |
0.05% |
|
|
| 35 |
Nationwide Fund Advisors |
11,678 |
57,000 |
0.04% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
11,132 |
55,000 |
0.04% |
|
|
| 37 |
Veritable, L.P. |
10,400 |
51,000 |
0.04% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
9,252 |
44,000 |
0.03% |
|
|
| 39 |
SIMPLEX TRADING, LLC |
7,275 |
35,000 |
0.03% |
|
|
| 40 |
GROUP ONE TRADING LLC |
6,586 |
32,000 |
0.02% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,131 |
30,000 |
0.02% |
|
|
| 42 |
UBS Group AG |
6,144 |
30,000 |
0.02% |
|
|
| 43 |
Creative Planning |
6,028 |
30,000 |
0.02% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
5,941 |
29,000 |
0.02% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
3,101 |
16,000 |
0.01% |
|
|
| 46 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
1,800 |
9,000 |
0.01% |
|
|
| 47 |
Legal & General Group Plc |
1,788 |
9,000 |
0.01% |
|
|
| 48 |
ROYAL BANK OF CANADA |
1,726 |
9,000 |
0.01% |
|
|
| 49 |
NEW YORK STATE COMMON RETIREMENT FUND |
1,500 |
7,000 |
0.01% |
|
|
| 50 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1,250 |
6,000 |
0.00% |
|
|
