| 1 |
First Eagle Investment Management, LLC |
10,912,733 |
11,567,000 |
25.33% |
|
|
| 2 |
Nantahala Capital Management, LLC |
9,700,043 |
10,282,000 |
22.51% |
|
|
| 3 |
BVF INC/IL |
7,400,128 |
7,844,000 |
17.17% |
|
|
| 4 |
VANGUARD GROUP INC |
3,021,618 |
3,203,000 |
7.01% |
|
|
| 5 |
NEA Management Company, LLC |
2,520,316 |
2,672,000 |
5.85% |
|
|
| 6 |
BlackRock Finance, Inc. |
2,225,641 |
2,359,000 |
5.17% |
|
|
| 7 |
RENAISSANCE TECHNOLOGIES LLC |
2,012,700 |
2,133,000 |
4.67% |
|
|
| 8 |
D. E. Shaw & Co., Inc. |
1,016,173 |
1,077,000 |
2.36% |
|
|
| 9 |
DAFNA Capital Management LLC |
807,008 |
855,000 |
1.87% |
|
|
| 10 |
Opaleye Management Inc. |
560,000 |
593,000 |
1.30% |
|
|
| 11 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
508,093 |
539,000 |
1.18% |
|
|
| 12 |
FMR LLC |
500,000 |
530,000 |
1.16% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
323,680 |
343,000 |
0.75% |
|
|
| 14 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
225,900 |
239,000 |
0.52% |
|
|
| 15 |
NORTHERN TRUST CORP |
153,128 |
162,000 |
0.35% |
|
|
| 16 |
STONERIDGE INVESTMENT PARTNERS LLC |
133,267 |
141,000 |
0.31% |
|
|
| 17 |
State of New Jersey Common Pension Fund D |
108,040 |
115,000 |
0.25% |
|
|
| 18 |
DIMENSIONAL FUND ADVISORS LP |
106,746 |
113,000 |
0.25% |
|
|
| 19 |
NEW YORK STATE COMMON RETIREMENT FUND |
99,000 |
105,000 |
0.23% |
|
|
| 20 |
GMT CAPITAL CORP |
92,863 |
98,000 |
0.21% |
|
|
| 21 |
NJ State Employees Deferred Compensation Plan |
86,202 |
91,000 |
0.20% |
|
|
| 22 |
Connor, Clark & Lunn Investment Management Ltd. |
80,899 |
86,000 |
0.19% |
|
|
| 23 |
Bank of New York Mellon Corp |
69,099 |
73,000 |
0.16% |
|
|
| 24 |
PANAGORA ASSET MANAGEMENT INC |
55,170 |
58,000 |
0.13% |
|
|
| 25 |
Curbstone Financial Management Corp |
52,286 |
55,000 |
0.12% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
41,569 |
44,000 |
0.10% |
|
|
| 27 |
Virtu KCG Holdings LLC |
41,285 |
44,000 |
0.10% |
|
|
| 28 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
36,852 |
39,000 |
0.09% |
|
|
| 29 |
MORGAN STANLEY |
33,700 |
36,000 |
0.08% |
|
|
| 30 |
STATE STREET CORP |
33,095 |
35,000 |
0.08% |
|
|
| 31 |
OPPENHEIMER & CO INC |
26,000 |
28,000 |
0.06% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,000 |
23,000 |
0.05% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
21,466 |
23,000 |
0.05% |
|
|
| 34 |
GUGGENHEIM CAPITAL LLC |
14,749 |
16,000 |
0.04% |
|
|
| 35 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
12,400 |
13,000 |
0.03% |
Call |
|
| 36 |
RWA WEALTH PARTNERS, LLC |
10,853 |
12,000 |
0.03% |
|
|
| 37 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
6,183 |
7,000 |
0.02% |
|
|
| 38 |
UBS Group AG |
6,100 |
6,000 |
0.01% |
|
|
| 39 |
Creative Planning |
5,000 |
5,000 |
0.01% |
|
|
| 40 |
ROYAL BANK OF CANADA |
1,520 |
2,000 |
0.00% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,233 |
2,000 |
0.00% |
|
|
| 42 |
SIMPLEX TRADING, LLC |
1,581 |
1,000 |
0.00% |
|
|
| 43 |
JPMORGAN CHASE & CO |
523 |
1,000 |
0.00% |
|
|
| 44 |
Financial Architects, Inc |
500 |
1,000 |
0.00% |
|
|
| 45 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
900 |
1,000 |
0.00% |
|
|
| 46 |
CUTLER GROUP LLC / CA |
1 |
0 |
0.00% |
|
|
