| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 6,446,089 | 200,602,000 | 28.73% | ||
| 2 | FMR LLC | 3,899,931 | 121,366,000 | 17.38% | ||
| 3 | MPM ASSET MANAGEMENT LLC | 2,413,819 | 75,118,000 | 10.76% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 1,185,662 | 36,898,000 | 5.29% | ||
| 5 | QVT Financial LP | 1,009,600 | 31,419,000 | 4.50% | ||
| 6 | VANGUARD GROUP INC | 711,732 | 22,149,000 | 3.17% | ||
| 7 | BlackRock Fund Advisors | 674,635 | 20,995,000 | 3.01% | ||
| 8 | GILDER GAGNON HOWE & CO LLC | 575,637 | 17,914,000 | 2.57% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 524,531 | 16,323,000 | 2.34% | ||
| 10 | JPMORGAN CHASE & CO | 500,352 | 15,571,000 | 2.23% | ||
| 11 | BLACKROCK ADVISORS LLC | 415,616 | 12,933,000 | 1.85% | ||
| 12 | Capital World Investors | 384,000 | 11,950,000 | 1.71% | ||
| 13 | LORD, ABBETT & CO. LLC | 366,751 | 11,413,000 | 1.63% | ||
| 14 | EMERALD ADVISERS, LLC | 280,182 | 8,719,000 | 1.25% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 262,361 | 8,165,000 | 1.17% | ||
| 16 | EMERALD MUTUAL FUND ADVISERS TRUST | 251,748 | 7,834,000 | 1.12% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 232,968 | 7,250,000 | 1.04% | ||
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 225,051 | 7,004,000 | 1.00% | ||
| 19 | BAKER BROS. ADVISORS LP | 214,012 | 6,660,000 | 0.95% | ||
| 20 | STATE STREET CORP | 153,687 | 4,783,000 | 0.69% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 142,094 | 4,422,000 | 0.63% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 113,188 | 3,522,000 | 0.50% | ||
| 23 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 111,866 | 3,482,000 | 0.50% | ||
| 24 | NORTHERN TRUST CORP | 88,704 | 2,761,000 | 0.40% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 75,082 | 2,336,000 | 0.33% | ||
| 26 | PRINCIPAL FINANCIAL GROUP INC | 73,800 | 2,297,000 | 0.33% | ||
| 27 | AXA S.A. | 73,000 | 2,272,000 | 0.33% | ||
| 28 | Tekla Capital Management LLC | 70,162 | 2,183,000 | 0.31% | ||
| 29 | CITIGROUP INC | 66,787 | 2,078,000 | 0.30% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 63,740 | 1,984,000 | 0.28% | ||
| 31 | BlackRock Investment Management, LLC | 55,226 | 1,719,000 | 0.25% | ||
| 32 | Bank of New York Mellon Corp | 51,105 | 1,591,000 | 0.23% | ||
| 33 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 49,700 | 1,547,000 | 0.22% | ||
| 34 | SABBY MANAGEMENT, LLC | 48,790 | 1,518,000 | 0.22% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,172 | 1,499,000 | 0.21% | ||
| 36 | DEUTSCHE BANK AG\ | 43,365 | 1,349,000 | 0.19% | ||
| 37 | PERCEPTIVE ADVISORS LLC | 42,602 | 1,326,000 | 0.19% | ||
| 38 | Hemenway Trust Co LLC | 31,000 | 965,000 | 0.14% | ||
| 39 | GREEN ARROW CAPITAL MANAGEMENT LLC | 30,000 | 934,000 | 0.13% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,655 | 861,000 | 0.12% | ||
| 41 | ProShare Advisors LLC | 26,370 | 821,000 | 0.12% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,404 | 728,000 | 0.10% | ||
| 43 | D. E. Shaw & Co., Inc. | 21,900 | 682,000 | 0.10% | ||
| 44 | TD ASSET MANAGEMENT INC | 20,700 | 644,000 | 0.09% | ||
| 45 | MACQUARIE GROUP LTD | 20,000 | 622,000 | 0.09% | ||
| 46 | DekaBank Deutsche Girozentrale | 19,000 | 591,000 | 0.08% | ||
| 47 | TEACHERS ADVISORS, LLC | 18,154 | 565,000 | 0.08% | ||
| 48 | MORGAN STANLEY | 17,792 | 554,000 | 0.08% | ||
| 49 | JANE STREET GROUP, LLC | 17,175 | 534,000 | 0.08% | ||
| 50 | J.P. Morgan Private Wealth Advisors LLC | 15,856 | 493,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
