| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRIMECAP MANAGEMENT CO/CA/ | 6,023,605 | 113,123,000 | 19.05% | ||
| 2 | FMR LLC | 5,366,439 | 100,782,000 | 16.97% | ||
| 3 | NEA Management Company, LLC | 5,149,740 | 96,712,000 | 16.29% | ||
| 4 | MPM ASSET MANAGEMENT LLC | 2,163,819 | 40,637,000 | 6.84% | ||
| 5 | EcoR1 Capital, LLC | 1,580,400 | 29,680,000 | 5.00% | ||
| 6 | VANGUARD GROUP INC | 1,395,417 | 26,206,000 | 4.41% | ||
| 7 | Point72 Asset Management, L.P. | 840,200 | 15,779,000 | 2.66% | ||
| 8 | QVT Financial LP | 831,000 | 15,606,000 | 2.63% | ||
| 9 | BlackRock Fund Advisors | 825,082 | 15,495,000 | 2.61% | ||
| 10 | Foresite Capital Management II, LLC | 754,806 | 14,175,000 | 2.39% | ||
| 11 | Allianz Asset Management GmbH | 525,000 | 9,861,000 | 1.66% | ||
| 12 | BALYASNY ASSET MANAGEMENT L.P. | 502,031 | 9,428,000 | 1.59% | ||
| 13 | NORGES BANK | 431,395 | 8,102,000 | 1.36% | ||
| 14 | Alyeska Investment Group, L.P. | 350,000 | 6,573,000 | 1.11% | ||
| 15 | DEUTSCHE BANK AG\ | 326,646 | 6,133,000 | 1.03% | ||
| 16 | Rock Springs Capital Management LP | 306,500 | 5,756,000 | 0.97% | ||
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 266,801 | 5,011,000 | 0.84% | ||
| 18 | Cormorant Asset Management, LP | 266,250 | 5,000,000 | 0.84% | ||
| 19 | JENNISON ASSOCIATES LLC | 250,138 | 4,698,000 | 0.79% | ||
| 20 | BAKER BROS. ADVISORS LP | 232,481 | 4,366,000 | 0.74% | ||
| 21 | Tekla Capital Management LLC | 200,000 | 3,756,000 | 0.63% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 193,695 | 3,638,000 | 0.61% | ||
| 23 | STATE STREET CORP | 189,749 | 3,561,000 | 0.60% | ||
| 24 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 2,817,000 | 0.47% | ||
| 25 | NORTHERN TRUST CORP | 144,644 | 2,716,000 | 0.46% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 135,544 | 2,545,000 | 0.43% | ||
| 27 | Candriam S.C.A. | 130,000 | 2,442,000 | 0.41% | ||
| 28 | Ghost Tree Capital, LLC | 115,000 | 2,160,000 | 0.36% | ||
| 29 | SABBY MANAGEMENT, LLC | 111,536 | 2,095,000 | 0.35% | ||
| 30 | QS Investors, LLC | 94,526 | 1,776,000 | 0.30% | ||
| 31 | STONERIDGE INVESTMENT PARTNERS LLC | 89,140 | 1,674,000 | 0.28% | ||
| 32 | LORD, ABBETT & CO. LLC | 87,134 | 1,637,000 | 0.28% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 78,442 | 1,473,000 | 0.25% | ||
| 34 | Bank of New York Mellon Corp | 77,400 | 1,453,000 | 0.24% | ||
| 35 | PRINCIPAL FINANCIAL GROUP INC | 73,900 | 1,388,000 | 0.23% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 70,180 | 1,318,000 | 0.22% | ||
| 37 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 70,000 | 1,315,000 | 0.22% | ||
| 38 | JPMORGAN CHASE & CO | 62,527 | 1,175,000 | 0.20% | ||
| 39 | MONASHEE INVESTMENT MANAGEMENT LLC | 59,100 | 1,110,000 | 0.19% | ||
| 40 | Trexquant Investment LP | 57,124 | 1,072,000 | 0.18% | ||
| 41 | MUHLENKAMP & CO INC | 51,860 | 974,000 | 0.16% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 51,716 | 972,000 | 0.16% | ||
| 43 | BLACKROCK ADVISORS LLC | 50,679 | 952,000 | 0.16% | ||
| 44 | Opus Point Partners Management, LLC | 48,339 | 908,000 | 0.15% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 46,260 | 869,000 | 0.15% | ||
| 46 | BlackRock Investment Management, LLC | 42,721 | 802,000 | 0.14% | ||
| 47 | CITADEL ADVISORS LLC | 40,287 | 756,000 | 0.13% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 38,455 | 723,000 | 0.12% | ||
| 49 | CREDIT SUISSE AG/ | 38,395 | 720,000 | 0.12% | ||
| 50 | MARSHALL WACE, LLP | 35,665 | 669,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
