| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 5,149,740 | 97,176,000 | 21.70% | ||
| 2 | FMR LLC | 4,391,746 | 82,872,000 | 18.51% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 4,114,008 | 77,631,000 | 17.34% | ||
| 4 | MPM ASSET MANAGEMENT LLC | 2,413,819 | 45,549,000 | 10.17% | ||
| 5 | VANGUARD GROUP INC | 1,088,490 | 20,540,000 | 4.59% | ||
| 6 | QVT Financial LP | 943,200 | 17,798,000 | 3.97% | ||
| 7 | BlackRock Fund Advisors | 731,040 | 13,795,000 | 3.08% | ||
| 8 | EMERALD ADVISERS, LLC | 496,000 | 9,360,000 | 2.09% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 432,619 | 8,164,000 | 1.82% | ||
| 10 | EMERALD MUTUAL FUND ADVISERS TRUST | 428,145 | 8,079,000 | 1.80% | ||
| 11 | NORGES BANK | 331,224 | 6,250,000 | 1.40% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 234,640 | 4,428,000 | 0.99% | ||
| 13 | WELLINGTON MANAGEMENT GROUP LLP | 211,141 | 3,984,000 | 0.89% | ||
| 14 | BAKER BROS. ADVISORS LP | 201,963 | 3,811,000 | 0.85% | ||
| 15 | Foresite Capital Management II, LLC | 201,806 | 3,808,000 | 0.85% | ||
| 16 | Rock Springs Capital Management LP | 181,500 | 3,425,000 | 0.76% | ||
| 17 | STATE STREET CORP | 171,894 | 3,244,000 | 0.72% | ||
| 18 | GILDER GAGNON HOWE & CO LLC | 140,319 | 2,648,000 | 0.59% | ||
| 19 | NORTHERN TRUST CORP | 136,398 | 2,573,000 | 0.57% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 131,874 | 2,488,000 | 0.56% | ||
| 21 | LORD, ABBETT & CO. LLC | 111,114 | 2,097,000 | 0.47% | ||
| 22 | QS Investors, LLC | 94,526 | 1,784,000 | 0.40% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 85,105 | 1,605,000 | 0.36% | ||
| 24 | PRINCIPAL FINANCIAL GROUP INC | 73,500 | 1,387,000 | 0.31% | ||
| 25 | Candriam S.C.A. | 70,000 | 1,321,000 | 0.29% | ||
| 26 | Numeric Investors LLC | 58,896 | 1,111,000 | 0.25% | ||
| 27 | JPMORGAN CHASE & CO | 56,625 | 1,069,000 | 0.24% | ||
| 28 | Bank of New York Mellon Corp | 56,666 | 1,069,000 | 0.24% | ||
| 29 | A.R.T. Advisors, LLC | 56,440 | 1,065,000 | 0.24% | ||
| 30 | MORGAN STANLEY | 53,947 | 1,018,000 | 0.23% | ||
| 31 | CREDIT SUISSE AG/ | 51,805 | 978,000 | 0.22% | ||
| 32 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 51,800 | 977,000 | 0.22% | ||
| 33 | CITADEL ADVISORS LLC | 50,975 | 962,000 | 0.21% | ||
| 34 | Trexquant Investment LP | 46,613 | 879,000 | 0.20% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 46,260 | 873,000 | 0.19% | ||
| 36 | BLACKROCK ADVISORS LLC | 39,016 | 736,000 | 0.16% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 36,539 | 690,000 | 0.15% | ||
| 38 | DEUTSCHE BANK AG\ | 36,646 | 690,000 | 0.15% | ||
| 39 | BlackRock Investment Management, LLC | 35,022 | 661,000 | 0.15% | ||
| 40 | Connor, Clark & Lunn Investment Management Ltd. | 33,400 | 630,000 | 0.14% | ||
| 41 | TFS CAPITAL LLC | 33,108 | 625,000 | 0.14% | ||
| 42 | Opus Point Partners Management, LLC | 28,339 | 535,000 | 0.12% | ||
| 43 | GOLDMAN SACHS GROUP INC | 27,627 | 521,000 | 0.12% | ||
| 44 | ProShare Advisors LLC | 25,378 | 479,000 | 0.11% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,739 | 448,000 | 0.10% | ||
| 46 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 20,103 | 379,344 | 0.08% | ||
| 47 | MACQUARIE GROUP LTD | 20,000 | 377,000 | 0.08% | ||
| 48 | TEACHERS ADVISORS, LLC | 18,154 | 343,000 | 0.08% | ||
| 49 | Hemenway Trust Co LLC | 18,000 | 340,000 | 0.08% | ||
| 50 | DekaBank Deutsche Girozentrale | 18,000 | 321,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
