| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 6,446,089 | 146,777,000 | 29.72% | ||
| 2 | FMR LLC | 3,750,109 | 85,390,000 | 17.29% | ||
| 3 | MPM ASSET MANAGEMENT LLC | 2,413,819 | 54,963,000 | 11.13% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 1,183,750 | 26,954,000 | 5.46% | ||
| 5 | VANGUARD GROUP INC | 687,116 | 15,646,000 | 3.17% | ||
| 6 | JPMORGAN CHASE & CO | 594,241 | 13,531,000 | 2.74% | ||
| 7 | GILDER GAGNON HOWE & CO LLC | 576,487 | 13,127,000 | 2.66% | ||
| 8 | BlackRock Fund Advisors | 569,067 | 12,958,000 | 2.62% | ||
| 9 | QVT Financial LP | 477,700 | 10,877,000 | 2.20% | ||
| 10 | CITIGROUP INC | 458,721 | 10,445,000 | 2.11% | ||
| 11 | BLACKROCK ADVISORS LLC | 400,155 | 9,111,000 | 1.84% | ||
| 12 | Capital World Investors | 384,000 | 8,744,000 | 1.77% | ||
| 13 | EMERALD ADVISERS, LLC | 280,752 | 6,393,000 | 1.29% | ||
| 14 | SAC Capital Advisors LP | 275,030 | 6,262,000 | 1.27% | ||
| 15 | Numeric Investors LLC | 257,574 | 5,865,000 | 1.19% | ||
| 16 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 249,865 | 5,688,000 | 1.15% | ||
| 17 | EMERALD MUTUAL FUND ADVISERS TRUST | 242,838 | 5,529,000 | 1.12% | ||
| 18 | BAKER BROS. ADVISORS LP | 214,012 | 4,873,000 | 0.99% | ||
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 209,781 | 4,777,000 | 0.97% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 198,643 | 4,523,000 | 0.92% | ||
| 21 | SABBY MANAGEMENT, LLC | 151,220 | 3,443,000 | 0.70% | ||
| 22 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 120,966 | 2,755,000 | 0.56% | ||
| 23 | Opaleye Management Inc. | 115,500 | 2,630,000 | 0.53% | ||
| 24 | LORD, ABBETT & CO. LLC | 106,436 | 2,424,000 | 0.49% | ||
| 25 | STATE STREET CORP | 104,389 | 2,380,000 | 0.48% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 84,174 | 1,917,000 | 0.39% | ||
| 27 | NORTHERN TRUST CORP | 83,166 | 1,894,000 | 0.38% | ||
| 28 | PRINCIPAL FINANCIAL GROUP INC | 73,800 | 1,680,000 | 0.34% | ||
| 29 | AXA S.A. | 73,000 | 1,662,000 | 0.34% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 70,452 | 1,604,000 | 0.32% | ||
| 31 | TEACHERS ADVISORS, LLC | 64,443 | 1,467,000 | 0.30% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,304 | 1,214,000 | 0.25% | ||
| 33 | PERCEPTIVE ADVISORS LLC | 52,602 | 1,198,000 | 0.24% | ||
| 34 | Laurion Capital Management LP | 50,900 | 1,159,000 | 0.23% | ||
| 35 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 49,700 | 1,132,000 | 0.23% | ||
| 36 | Ghost Tree Capital, LLC | 45,000 | 1,025,000 | 0.21% | ||
| 37 | Hemenway Trust Co LLC | 40,000 | 911,000 | 0.18% | ||
| 38 | DEUTSCHE BANK AG\ | 34,871 | 792,000 | 0.16% | ||
| 39 | ProShare Advisors LLC | 31,881 | 726,000 | 0.15% | ||
| 40 | J.P. Morgan Private Wealth Advisors LLC | 30,856 | 703,000 | 0.14% | ||
| 41 | Bank of New York Mellon Corp | 26,750 | 609,000 | 0.12% | ||
| 42 | HAP Trading, LLC | 25,415 | 579,000 | 0.12% | ||
| 43 | Broderick Brian C | 25,000 | 569,000 | 0.12% | ||
| 44 | CREDIT SUISSE AG/ | 24,518 | 559,000 | 0.11% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 22,724 | 517,000 | 0.10% | ||
| 46 | HAP Trading, LLC | 56,700 | 471,000 | 0.10% | Put | |
| 47 | MACQUARIE GROUP LTD | 20,000 | 455,000 | 0.09% | ||
| 48 | BlackRock Investment Management, LLC | 18,700 | 426,000 | 0.09% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,431 | 397,000 | 0.08% | ||
| 50 | DekaBank Deutsche Girozentrale | 17,000 | 387,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
