| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 5,149,740 | 139,609,000 | 21.85% | ||
| 2 | FMR LLC | 4,359,731 | 118,192,000 | 18.50% | ||
| 3 | MPM ASSET MANAGEMENT LLC | 2,413,819 | 65,439,000 | 10.24% | ||
| 4 | PRIMECAP MANAGEMENT CO/CA/ | 1,421,662 | 38,541,000 | 6.03% | ||
| 5 | VANGUARD GROUP INC | 1,019,236 | 27,631,000 | 4.32% | ||
| 6 | QVT Financial LP | 1,009,600 | 27,370,000 | 4.28% | ||
| 7 | LORD, ABBETT & CO. LLC | 766,965 | 20,792,000 | 3.25% | ||
| 8 | STATE STREET CORP | 695,058 | 18,840,000 | 2.95% | ||
| 9 | BlackRock Fund Advisors | 688,513 | 18,666,000 | 2.92% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 585,771 | 15,880,000 | 2.49% | ||
| 11 | GILDER GAGNON HOWE & CO LLC | 570,139 | 15,456,000 | 2.42% | ||
| 12 | JPMORGAN CHASE & CO | 500,852 | 13,578,000 | 2.13% | ||
| 13 | Capital World Investors | 384,000 | 10,410,000 | 1.63% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 283,890 | 7,696,000 | 1.20% | ||
| 15 | EMERALD ADVISERS, LLC | 269,882 | 7,317,000 | 1.15% | ||
| 16 | EMERALD MUTUAL FUND ADVISERS TRUST | 250,678 | 6,796,000 | 1.06% | ||
| 17 | CITADEL ADVISORS LLC | 227,575 | 6,170,000 | 0.97% | ||
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 217,511 | 5,896,000 | 0.92% | ||
| 19 | BAKER BROS. ADVISORS LP | 214,012 | 5,802,000 | 0.91% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 179,409 | 4,864,000 | 0.76% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 173,800 | 4,712,000 | 0.74% | ||
| 22 | Point72 Asset Management, L.P. | 154,721 | 4,194,000 | 0.66% | ||
| 23 | Numeric Investors LLC | 145,800 | 3,953,000 | 0.62% | ||
| 24 | NORTHERN TRUST CORP | 143,455 | 3,889,000 | 0.61% | ||
| 25 | Tekla Capital Management LLC | 141,262 | 3,830,000 | 0.60% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 133,371 | 3,616,000 | 0.57% | ||
| 27 | Rock Springs Capital Management LP | 131,000 | 3,551,000 | 0.56% | ||
| 28 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 102,466 | 2,778,000 | 0.43% | ||
| 29 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,000 | 2,711,000 | 0.42% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 88,979 | 2,412,000 | 0.38% | ||
| 31 | PRINCIPAL FINANCIAL GROUP INC | 72,600 | 1,968,000 | 0.31% | ||
| 32 | Bank of New York Mellon Corp | 60,227 | 1,632,000 | 0.26% | ||
| 33 | MORGAN STANLEY | 58,503 | 1,586,000 | 0.25% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,415 | 1,557,000 | 0.24% | ||
| 35 | SPHERA FUNDS MANAGEMENT LTD. | 50,000 | 1,356,000 | 0.21% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 48,731 | 1,321,000 | 0.21% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,172 | 1,306,000 | 0.20% | ||
| 38 | CREDIT SUISSE AG/ | 46,002 | 1,247,000 | 0.20% | ||
| 39 | BlackRock Investment Management, LLC | 35,375 | 959,000 | 0.15% | ||
| 40 | DEUTSCHE BANK AG\ | 33,228 | 900,000 | 0.14% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,211 | 765,000 | 0.12% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,900 | 729,000 | 0.11% | Call | |
| 43 | MARSHALL WACE, LLP | 26,059 | 706,000 | 0.11% | ||
| 44 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 24,400 | 661,000 | 0.10% | ||
| 45 | ProShare Advisors LLC | 22,391 | 607,000 | 0.09% | ||
| 46 | PDT Partners, LLC | 21,620 | 586,000 | 0.09% | ||
| 47 | MACQUARIE GROUP LTD | 20,000 | 542,000 | 0.08% | ||
| 48 | DekaBank Deutsche Girozentrale | 19,700 | 534,000 | 0.08% | ||
| 49 | TEACHERS ADVISORS, LLC | 18,154 | 492,000 | 0.08% | ||
| 50 | Hemenway Trust Co LLC | 18,000 | 488,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
