| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,166,247 | 80,356,000 | 17.45% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 6,525,327 | 64,209,000 | 13.94% | ||
| 3 | NEA Management Company, LLC | 6,260,851 | 61,607,000 | 13.38% | ||
| 4 | VANGUARD GROUP INC | 2,959,095 | 29,118,000 | 6.32% | ||
| 5 | Palo Alto Investors LP | 2,814,540 | 27,695,000 | 6.01% | ||
| 6 | BlackRock Fund Advisors | 1,798,729 | 17,699,000 | 3.84% | ||
| 7 | JENNISON ASSOCIATES LLC | 1,749,735 | 17,217,000 | 3.74% | ||
| 8 | MPM ASSET MANAGEMENT LLC | 1,729,674 | 17,020,000 | 3.70% | ||
| 9 | Foresite Capital Management II, LLC | 1,543,118 | 15,184,000 | 3.30% | ||
| 10 | FRANKLIN RESOURCES INC | 1,200,000 | 11,808,000 | 2.56% | ||
| 11 | VOYA INVESTMENT MANAGEMENT LLC | 877,720 | 8,637,000 | 1.88% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 867,884 | 8,540,000 | 1.85% | ||
| 13 | QVT Financial LP | 850,446 | 8,368,000 | 1.82% | ||
| 14 | STATE STREET CORP | 728,776 | 7,173,000 | 1.56% | ||
| 15 | Rock Springs Capital Management LP | 642,500 | 6,322,000 | 1.37% | ||
| 16 | CQS Cayman LP | 634,300 | 6,242,000 | 1.36% | ||
| 17 | FORESITE CAPITAL MANAGEMENT III, LLC | 611,777 | 6,020,000 | 1.31% | ||
| 18 | NORGES BANK | 492,631 | 4,630,000 | 1.01% | ||
| 19 | NORTHERN TRUST CORP | 452,789 | 4,456,000 | 0.97% | ||
| 20 | Tekla Capital Management LLC | 400,000 | 3,936,000 | 0.85% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 295,821 | 2,910,000 | 0.63% | ||
| 22 | CASDIN CAPITAL, LLC | 295,000 | 2,903,000 | 0.63% | ||
| 23 | DEERFIELD MANAGEMENT COMPANY, L.P. | 291,179 | 2,865,000 | 0.62% | ||
| 24 | EVENTIDE ASSET MANAGEMENT, LLC | 275,000 | 2,706,000 | 0.59% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 274,613 | 2,702,000 | 0.59% | ||
| 26 | MORGAN STANLEY | 256,067 | 2,519,000 | 0.55% | ||
| 27 | BAKER BROS. ADVISORS LP | 232,481 | 2,288,000 | 0.50% | ||
| 28 | DEUTSCHE BANK AG\ | 224,674 | 2,210,000 | 0.48% | ||
| 29 | JPMORGAN CHASE & CO | 224,600 | 2,210,000 | 0.48% | ||
| 30 | SECOR Capital Advisors, LP | 186,948 | 1,840,000 | 0.40% | ||
| 31 | Candriam S.C.A. | 184,000 | 1,811,000 | 0.39% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 180,288 | 1,774,000 | 0.39% | ||
| 33 | Bank of New York Mellon Corp | 165,819 | 1,631,000 | 0.35% | ||
| 34 | Cormorant Asset Management, LP | 159,513 | 1,570,000 | 0.34% | ||
| 35 | BlackRock Investment Management, LLC | 153,494 | 1,510,000 | 0.33% | ||
| 36 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 145,400 | 1,431,000 | 0.31% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 126,977 | 1,249,000 | 0.27% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 122,528 | 1,206,000 | 0.26% | ||
| 39 | QS Investors, LLC | 94,526 | 930,000 | 0.20% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 92,900 | 914,000 | 0.20% | Put | |
| 41 | PRINCIPAL FINANCIAL GROUP INC | 89,924 | 885,000 | 0.19% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 85,141 | 838,000 | 0.18% | ||
| 43 | J. Goldman & Co LP | 80,000 | 787,000 | 0.17% | ||
| 44 | Iguana Healthcare Management, LLC | 75,000 | 738,000 | 0.16% | ||
| 45 | ALPS ADVISORS INC | 73,886 | 727,000 | 0.16% | ||
| 46 | TEACHERS ADVISORS, LLC | 67,829 | 667,000 | 0.14% | ||
| 47 | Swiss National Bank | 56,500 | 556,000 | 0.12% | ||
| 48 | PDT Partners, LLC | 55,700 | 548,000 | 0.12% | ||
| 49 | AMERICAN CENTURY COMPANIES INC | 51,456 | 506,000 | 0.11% | ||
| 50 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 48,867 | 481,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
