| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,180,700 | 99,015,000 | 18.23% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 5,245,627 | 84,035,000 | 15.47% | ||
| 3 | NEA Management Company, LLC | 5,149,740 | 82,499,000 | 15.19% | ||
| 4 | Palo Alto Investors LP | 2,660,979 | 42,629,000 | 7.85% | ||
| 5 | VANGUARD GROUP INC | 1,738,430 | 27,850,000 | 5.13% | ||
| 6 | MPM ASSET MANAGEMENT LLC | 1,729,674 | 27,709,000 | 5.10% | ||
| 7 | BlackRock Fund Advisors | 1,195,889 | 19,158,000 | 3.53% | ||
| 8 | Foresite Capital Management II, LLC | 1,159,795 | 18,580,000 | 3.42% | ||
| 9 | JENNISON ASSOCIATES LLC | 893,913 | 14,320,000 | 2.64% | ||
| 10 | STATE STREET CORP | 876,071 | 14,035,000 | 2.58% | ||
| 11 | EcoR1 Capital, LLC | 698,900 | 11,196,000 | 2.06% | ||
| 12 | QVT Financial LP | 595,314 | 9,537,000 | 1.76% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 591,688 | 9,479,000 | 1.75% | ||
| 14 | FORESITE CAPITAL MANAGEMENT III, LLC | 461,651 | 7,396,000 | 1.36% | ||
| 15 | NORGES BANK | 432,631 | 6,931,000 | 1.28% | ||
| 16 | Rock Springs Capital Management LP | 370,000 | 5,927,000 | 1.09% | ||
| 17 | CASDIN CAPITAL, LLC | 332,500 | 5,327,000 | 0.98% | ||
| 18 | NORTHERN TRUST CORP | 331,214 | 5,306,000 | 0.98% | ||
| 19 | MORGAN STANLEY | 292,735 | 4,690,000 | 0.86% | ||
| 20 | Cormorant Asset Management, LP | 266,250 | 4,265,000 | 0.79% | ||
| 21 | BAKER BROS. ADVISORS LP | 232,481 | 3,724,000 | 0.69% | ||
| 22 | Spark Investment Management LLC | 217,100 | 3,477,000 | 0.64% | ||
| 23 | Candriam S.C.A. | 181,000 | 2,900,000 | 0.53% | ||
| 24 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 170,000 | 2,723,000 | 0.50% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 164,686 | 2,637,000 | 0.49% | ||
| 26 | Opus Point Partners Management, LLC | 135,627 | 2,173,000 | 0.40% | ||
| 27 | Bank of New York Mellon Corp | 118,535 | 1,899,000 | 0.35% | ||
| 28 | BlackRock Investment Management, LLC | 96,396 | 1,544,000 | 0.28% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 96,004 | 1,538,000 | 0.28% | ||
| 30 | QS Investors, LLC | 94,526 | 1,514,000 | 0.28% | ||
| 31 | PRINCIPAL FINANCIAL GROUP INC | 83,179 | 1,333,000 | 0.25% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 80,104 | 1,284,000 | 0.24% | ||
| 33 | LORD, ABBETT & CO. LLC | 78,041 | 1,250,000 | 0.23% | ||
| 34 | TFS CAPITAL LLC | 74,700 | 1,197,000 | 0.22% | ||
| 35 | FRED ALGER MANAGEMENT, LLC | 60,250 | 965,000 | 0.18% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,839 | 863,000 | 0.16% | ||
| 37 | MUHLENKAMP & CO INC | 50,000 | 801,000 | 0.15% | ||
| 38 | TEACHERS ADVISORS, LLC | 43,368 | 695,000 | 0.13% | ||
| 39 | UBS Group AG | 40,391 | 647,000 | 0.12% | ||
| 40 | ProShare Advisors LLC | 37,764 | 605,000 | 0.11% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 44,500 | 572,000 | 0.11% | ||
| 42 | Trexquant Investment LP | 35,219 | 564,000 | 0.10% | ||
| 43 | Piermont Capital Management Inc. | 32,239 | 516,000 | 0.09% | ||
| 44 | DEUTSCHE BANK AG\ | 30,232 | 484,000 | 0.09% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 28,700 | 460,000 | 0.08% | ||
| 46 | Swiss National Bank | 28,200 | 452,000 | 0.08% | ||
| 47 | RHUMBLINE ADVISERS | 27,634 | 443,000 | 0.08% | ||
| 48 | JPMORGAN CHASE & CO | 23,612 | 378,000 | 0.07% | ||
| 49 | DekaBank Deutsche Girozentrale | 21,000 | 349,000 | 0.06% | ||
| 50 | TCW GROUP INC | 20,714 | 332,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
