| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,166,247 | 98,812,000 | 16.74% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 6,543,327 | 79,174,000 | 13.41% | ||
| 3 | NEA Management Company, LLC | 6,260,851 | 75,756,000 | 12.83% | ||
| 4 | VANGUARD GROUP INC | 3,079,796 | 37,265,000 | 6.31% | ||
| 5 | Palo Alto Investors LP | 3,035,796 | 36,733,000 | 6.22% | ||
| 6 | BlackRock Fund Advisors | 2,015,105 | 24,383,000 | 4.13% | ||
| 7 | JENNISON ASSOCIATES LLC | 1,933,804 | 23,399,000 | 3.96% | ||
| 8 | MPM ASSET MANAGEMENT LLC | 1,729,674 | 20,929,000 | 3.55% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,601,049 | 19,373,000 | 3.28% | ||
| 10 | Foresite Capital Management II, LLC | 1,526,637 | 18,472,000 | 3.13% | ||
| 11 | FRANKLIN RESOURCES INC | 1,163,000 | 14,072,000 | 2.38% | ||
| 12 | STATE STREET CORP | 1,088,635 | 13,173,000 | 2.23% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 968,109 | 11,714,000 | 1.98% | ||
| 14 | VOYA INVESTMENT MANAGEMENT LLC | 858,599 | 10,388,000 | 1.76% | ||
| 15 | CQS Cayman LP | 634,300 | 7,675,000 | 1.30% | ||
| 16 | FORESITE CAPITAL MANAGEMENT III, LLC | 605,239 | 7,323,000 | 1.24% | ||
| 17 | Rock Springs Capital Management LP | 570,000 | 6,897,000 | 1.17% | ||
| 18 | QVT Financial LP | 530,281 | 6,416,000 | 1.09% | ||
| 19 | NORTHERN TRUST CORP | 500,898 | 6,061,000 | 1.03% | ||
| 20 | NORGES BANK | 492,631 | 5,961,000 | 1.01% | ||
| 21 | Ghost Tree Capital, LLC | 475,000 | 5,748,000 | 0.97% | ||
| 22 | Tekla Capital Management LLC | 400,000 | 4,840,000 | 0.82% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 322,448 | 3,901,000 | 0.66% | ||
| 24 | EVENTIDE ASSET MANAGEMENT, LLC | 275,000 | 3,328,000 | 0.56% | ||
| 25 | CASDIN CAPITAL, LLC | 275,000 | 3,328,000 | 0.56% | ||
| 26 | BAKER BROS. ADVISORS LP | 232,481 | 2,813,000 | 0.48% | ||
| 27 | JPMORGAN CHASE & CO | 209,400 | 2,534,000 | 0.43% | ||
| 28 | Candriam S.C.A. | 209,000 | 2,529,000 | 0.43% | ||
| 29 | Bank of New York Mellon Corp | 181,859 | 2,201,000 | 0.37% | ||
| 30 | Cormorant Asset Management, LP | 159,513 | 1,930,000 | 0.33% | ||
| 31 | J. Goldman & Co LP | 155,049 | 1,876,000 | 0.32% | ||
| 32 | BlackRock Investment Management, LLC | 153,062 | 1,852,000 | 0.31% | ||
| 33 | DEUTSCHE BANK AG\ | 151,982 | 1,838,000 | 0.31% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 144,822 | 1,752,000 | 0.30% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 138,400 | 1,675,000 | 0.28% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 128,996 | 1,561,000 | 0.26% | ||
| 37 | MORGAN STANLEY | 126,871 | 1,534,000 | 0.26% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 114,510 | 1,386,000 | 0.23% | ||
| 39 | QS Investors, LLC | 94,526 | 1,144,000 | 0.19% | ||
| 40 | PRINCIPAL FINANCIAL GROUP INC | 93,658 | 1,133,000 | 0.19% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,941 | 1,004,000 | 0.17% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,700 | 952,000 | 0.16% | Put | |
| 43 | TEACHERS ADVISORS, LLC | 67,829 | 821,000 | 0.14% | ||
| 44 | Swiss National Bank | 66,700 | 807,000 | 0.14% | ||
| 45 | ESSEX INVESTMENT MANAGEMENT CO LLC | 59,776 | 723,000 | 0.12% | ||
| 46 | ALPS ADVISORS INC | 55,748 | 675,000 | 0.11% | ||
| 47 | PDT Partners, LLC | 54,600 | 661,000 | 0.11% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,373 | 658,000 | 0.11% | ||
| 49 | GOLDMAN SACHS GROUP INC | 53,382 | 646,000 | 0.11% | ||
| 50 | RHUMBLINE ADVISERS | 47,435 | 574,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
