| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,186,332 | 202,454,000 | 14.05% | ||
| 2 | Aisling Capital LLC | 2,054,594 | 190,255,000 | 13.20% | ||
| 3 | Visium Asset Management, LP | 1,403,600 | 129,974,000 | 9.02% | ||
| 4 | Pentwater Capital Management LP | 1,296,000 | 120,010,000 | 8.33% | ||
| 5 | GILDER GAGNON HOWE & CO LLC | 805,990 | 74,635,000 | 5.18% | ||
| 6 | WASATCH ADVISORS LP | 755,571 | 69,966,000 | 4.85% | ||
| 7 | VANGUARD GROUP INC | 396,320 | 36,700,000 | 2.55% | ||
| 8 | STATE STREET CORP | 392,848 | 36,379,000 | 2.52% | ||
| 9 | Polar Capital LLP | 377,053 | 34,915,000 | 2.42% | ||
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 332,600 | 30,799,000 | 2.14% | Put | |
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 301,600 | 27,928,000 | 1.94% | Call | |
| 12 | COLUMBUS CIRCLE INVESTORS | 247,195 | 22,890,000 | 1.59% | ||
| 13 | Granahan Investment Management, LLC | 232,780 | 21,555,000 | 1.50% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 205,188 | 19,000,000 | 1.32% | ||
| 15 | Iguana Healthcare Management, LLC | 200,000 | 18,520,000 | 1.29% | ||
| 16 | BlackRock Fund Advisors | 186,692 | 17,288,000 | 1.20% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 173,336 | 16,051,000 | 1.11% | ||
| 18 | DEUTSCHE BANK AG\ | 170,444 | 15,781,000 | 1.10% | ||
| 19 | Candriam S.C.A. | 143,000 | 13,245,000 | 0.92% | ||
| 20 | TWO SIGMA INVESTMENTS, LP | 138,983 | 12,870,000 | 0.89% | ||
| 21 | VIKING GLOBAL INVESTORS LP | 136,919 | 12,679,000 | 0.88% | ||
| 22 | Rhenman & Partners Asset Management AB | 126,926 | 11,753,000 | 0.82% | ||
| 23 | PRICE T ROWE ASSOCIATES INC /MD/ | 124,644 | 11,542,000 | 0.80% | ||
| 24 | MARSHALL WACE, LLP | 116,138 | 10,754,000 | 0.75% | ||
| 25 | CITADEL ADVISORS LLC | 112,937 | 10,458,000 | 0.73% | ||
| 26 | Invesco Ltd. | 112,435 | 10,411,000 | 0.72% | ||
| 27 | TIVERTON ASSET MANAGEMENT LLC | 110,100 | 10,195,000 | 0.71% | ||
| 28 | JPMORGAN CHASE & CO | 107,674 | 9,970,000 | 0.69% | ||
| 29 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 94,527 | 8,754,000 | 0.61% | ||
| 30 | Informed Momentum Co LLC | 89,335 | 8,272,000 | 0.57% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 87,709 | 8,121,000 | 0.56% | ||
| 32 | SCHRODER INVESTMENT MANAGEMENT GROUP | 81,200 | 7,361,000 | 0.51% | ||
| 33 | AXA S.A. | 78,091 | 7,231,000 | 0.50% | ||
| 34 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 74,291 | 6,879,000 | 0.48% | ||
| 35 | Nicholas Investment Partners, LP | 72,909 | 6,751,000 | 0.47% | ||
| 36 | NORTHERN TRUST CORP | 71,234 | 6,596,000 | 0.46% | ||
| 37 | JENNISON ASSOCIATES LLC | 70,047 | 6,486,000 | 0.45% | ||
| 38 | Pier Capital, LLC | 69,909 | 6,474,000 | 0.45% | ||
| 39 | Bank of New York Mellon Corp | 69,406 | 6,427,000 | 0.45% | ||
| 40 | AQR CAPITAL MANAGEMENT LLC | 68,000 | 6,297,000 | 0.44% | ||
| 41 | Allianz Asset Management GmbH | 65,167 | 6,034,000 | 0.42% | ||
| 42 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 63,100 | 5,843,000 | 0.41% | Call | |
| 43 | MILLENNIUM MANAGEMENT LLC | 58,444 | 5,412,000 | 0.38% | ||
| 44 | OppenheimerFunds, Inc. | 56,355 | 5,218,000 | 0.36% | ||
| 45 | EverPoint Asset Management, LLC | 55,000 | 5,093,000 | 0.35% | ||
| 46 | MORGAN STANLEY | 51,971 | 4,813,000 | 0.33% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 49,865 | 4,617,000 | 0.32% | ||
| 48 | A.R.T. Advisors, LLC | 43,696 | 4,046,000 | 0.28% | ||
| 49 | CREDIT SUISSE AG/ | 43,613 | 4,039,000 | 0.28% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 40,432 | 3,744,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
