| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 1,637,125 | 27,684,000 | 10.12% | ||
| 2 | Pentwater Capital Management LP | 1,424,000 | 24,080,000 | 8.80% | ||
| 3 | FMR LLC | 1,175,750 | 19,882,000 | 7.27% | ||
| 4 | COLUMBUS CIRCLE INVESTORS | 1,115,467 | 18,863,000 | 6.89% | ||
| 5 | BB BIOTECH AG | 1,008,542 | 17,054,000 | 6.23% | ||
| 6 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 806,105 | 13,631,000 | 4.98% | ||
| 7 | WASATCH ADVISORS LP | 759,183 | 12,519,000 | 4.58% | ||
| 8 | VANGUARD GROUP INC | 736,776 | 12,459,000 | 4.55% | ||
| 9 | Sarissa Capital Management LP | 633,000 | 10,704,000 | 3.91% | ||
| 10 | VOYA INVESTMENT MANAGEMENT LLC | 632,392 | 10,693,000 | 3.91% | ||
| 11 | BVF INC/IL | 606,801 | 10,261,000 | 3.75% | ||
| 12 | BlackRock Fund Advisors | 606,342 | 10,253,000 | 3.75% | ||
| 13 | DEUTSCHE BANK AG\ | 438,459 | 7,412,000 | 2.71% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 330,950 | 5,596,000 | 2.05% | ||
| 15 | OXFORD ASSET MANAGEMENT LLP | 280,342 | 4,741,000 | 1.73% | ||
| 16 | STATE STREET CORP | 248,828 | 4,207,000 | 1.54% | ||
| 17 | Granahan Investment Management, LLC | 247,630 | 4,187,000 | 1.53% | ||
| 18 | Invesco Ltd. | 228,501 | 3,864,000 | 1.41% | ||
| 19 | A.R.T. Advisors, LLC | 200,858 | 3,396,000 | 1.24% | ||
| 20 | NORTHERN TRUST CORP | 191,513 | 3,239,000 | 1.18% | ||
| 21 | Rhenman & Partners Asset Management AB | 150,000 | 2,537,000 | 0.93% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,900 | 2,247,000 | 0.82% | Call | |
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 114,554 | 1,937,000 | 0.71% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 111,577 | 1,887,000 | 0.69% | ||
| 25 | TIVERTON ASSET MANAGEMENT LLC | 109,360 | 1,849,000 | 0.68% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 107,600 | 1,820,000 | 0.67% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 107,392 | 1,815,000 | 0.66% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 104,687 | 1,771,000 | 0.65% | ||
| 29 | Tekla Capital Management LLC | 102,800 | 1,738,000 | 0.64% | ||
| 30 | PAULSON & CO. INC. | 102,000 | 1,725,000 | 0.63% | ||
| 31 | JPMORGAN CHASE & CO | 99,800 | 1,687,000 | 0.62% | ||
| 32 | PRICE T ROWE ASSOCIATES INC /MD/ | 96,585 | 1,633,000 | 0.60% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,500 | 1,226,000 | 0.45% | Put | |
| 34 | CREDIT SUISSE AG/ | 65,522 | 1,109,000 | 0.41% | ||
| 35 | GAM Holding AG | 64,000 | 1,082,000 | 0.40% | ||
| 36 | Candriam S.C.A. | 64,000 | 1,076,000 | 0.39% | ||
| 37 | Bank of New York Mellon Corp | 63,613 | 1,075,000 | 0.39% | ||
| 38 | Glacier Peak Capital LLC | 38,048 | 989,000 | 0.36% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 50,900 | 861,000 | 0.31% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,550 | 788,000 | 0.29% | ||
| 41 | GOLDMAN SACHS GROUP INC | 45,300 | 766,000 | 0.28% | Call | |
| 42 | BlackRock Investment Management, LLC | 45,178 | 764,000 | 0.28% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 42,935 | 726,000 | 0.27% | ||
| 44 | GOLDMAN SACHS GROUP INC | 42,900 | 725,000 | 0.26% | Put | |
| 45 | Squarepoint Ops LLC | 41,600 | 703,000 | 0.26% | ||
| 46 | GOLDMAN SACHS GROUP INC | 41,012 | 694,000 | 0.25% | ||
| 47 | BELLEVUE GROUP AG | 40,000 | 676,000 | 0.25% | ||
| 48 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 35,280 | 597,000 | 0.22% | ||
| 49 | Telemetry Investments, L.L.C. | 33,000 | 558,000 | 0.20% | ||
| 50 | FT OPTIONS LLC | 31,296 | 529,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
