| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 1,637,125 | 22,674,000 | 11.16% | ||
| 2 | Pentwater Capital Management LP | 1,536,000 | 21,274,000 | 10.47% | ||
| 3 | BB BIOTECH AG | 1,308,542 | 18,123,000 | 8.92% | ||
| 4 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 1,050,000 | 14,543,000 | 7.16% | ||
| 5 | FMR LLC | 766,009 | 10,609,000 | 5.22% | ||
| 6 | BlackRock Fund Advisors | 698,775 | 9,678,000 | 4.76% | ||
| 7 | VOYA INVESTMENT MANAGEMENT LLC | 689,910 | 9,555,000 | 4.70% | ||
| 8 | VANGUARD GROUP INC | 568,203 | 7,870,000 | 3.87% | ||
| 9 | WASATCH ADVISORS LP | 526,717 | 7,295,000 | 3.59% | ||
| 10 | NORTHERN TRUST CORP | 504,375 | 6,985,000 | 3.44% | ||
| 11 | BVF INC/IL | 493,872 | 6,840,000 | 3.37% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 398,499 | 5,519,000 | 2.72% | ||
| 13 | CREDIT SUISSE AG/ | 389,753 | 5,398,000 | 2.66% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 318,800 | 4,415,000 | 2.17% | ||
| 15 | DEUTSCHE BANK AG\ | 269,509 | 3,731,000 | 1.84% | ||
| 16 | Granahan Investment Management, LLC | 248,030 | 3,435,000 | 1.69% | ||
| 17 | STATE STREET CORP | 243,746 | 3,377,000 | 1.66% | ||
| 18 | JPMORGAN CHASE & CO | 181,400 | 2,512,000 | 1.24% | ||
| 19 | Invesco Ltd. | 176,197 | 2,440,000 | 1.20% | ||
| 20 | Rhenman & Partners Asset Management AB | 130,000 | 1,800,500 | 0.89% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 111,046 | 1,537,000 | 0.76% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 107,371 | 1,487,000 | 0.73% | ||
| 23 | Tekla Capital Management LLC | 102,800 | 1,424,000 | 0.70% | ||
| 24 | PAULSON & CO. INC. | 102,000 | 1,413,000 | 0.70% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,068 | 1,400,000 | 0.69% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 100,060 | 1,386,000 | 0.68% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,100 | 1,068,000 | 0.53% | Put | |
| 28 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 74,961 | 1,038,000 | 0.51% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 74,598 | 1,033,000 | 0.51% | ||
| 30 | KENNEDY CAPITAL MANAGEMENT LLC | 69,877 | 968,000 | 0.48% | ||
| 31 | OXFORD ASSET MANAGEMENT LLP | 65,941 | 913,000 | 0.45% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,500 | 893,000 | 0.44% | Call | |
| 33 | GAM Holding AG | 64,000 | 886,000 | 0.44% | ||
| 34 | Bank of New York Mellon Corp | 61,320 | 849,000 | 0.42% | ||
| 35 | BlackRock Investment Management, LLC | 60,094 | 832,000 | 0.41% | ||
| 36 | D. E. Shaw & Co., Inc. | 52,339 | 725,000 | 0.36% | ||
| 37 | MARTINGALE ASSET MANAGEMENT L P | 51,179 | 709,000 | 0.35% | ||
| 38 | Candriam S.C.A. | 50,000 | 693,000 | 0.34% | ||
| 39 | GOLDMAN SACHS GROUP INC | 49,722 | 689,000 | 0.34% | ||
| 40 | UBS Group AG | 49,373 | 684,000 | 0.34% | ||
| 41 | MORGAN STANLEY | 49,102 | 680,000 | 0.33% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 46,000 | 637,000 | 0.31% | ||
| 43 | PDT Partners, LLC | 45,800 | 634,000 | 0.31% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 45,305 | 627,000 | 0.31% | ||
| 45 | Iguana Healthcare Management, LLC | 40,000 | 554,000 | 0.27% | ||
| 46 | BELLEVUE GROUP AG | 40,000 | 554,000 | 0.27% | ||
| 47 | Nationwide Fund Advisors | 39,665 | 549,000 | 0.27% | ||
| 48 | CITADEL ADVISORS LLC | 35,595 | 493,000 | 0.24% | ||
| 49 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 35,280 | 489,000 | 0.24% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 31,270 | 433,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
