| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,880,250 | 41,854,000 | 11.26% | ||
| 2 | Aisling Capital LLC | 1,637,125 | 36,442,000 | 9.80% | ||
| 3 | Pentwater Capital Management LP | 1,439,000 | 32,032,000 | 8.61% | ||
| 4 | STATE STREET CORP | 1,077,466 | 23,983,000 | 6.45% | ||
| 5 | COLUMBUS CIRCLE INVESTORS | 1,054,452 | 23,472,000 | 6.31% | ||
| 6 | BB BIOTECH AG | 908,542 | 20,224,000 | 5.44% | ||
| 7 | VANGUARD GROUP INC | 726,070 | 16,161,000 | 4.35% | ||
| 8 | WASATCH ADVISORS LP | 715,581 | 15,929,000 | 4.28% | ||
| 9 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 667,532 | 14,859,000 | 4.00% | ||
| 10 | BlackRock Fund Advisors | 588,889 | 13,109,000 | 3.53% | ||
| 11 | DEUTSCHE BANK AG\ | 470,295 | 10,468,000 | 2.82% | ||
| 12 | Sarissa Capital Management LP | 448,000 | 9,972,000 | 2.68% | ||
| 13 | VOYA INVESTMENT MANAGEMENT LLC | 447,842 | 9,969,000 | 2.68% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 361,200 | 8,040,000 | 2.16% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 326,479 | 7,267,000 | 1.95% | ||
| 16 | Granahan Investment Management, LLC | 247,630 | 5,512,000 | 1.48% | ||
| 17 | SENZAR ASSET MANAGEMENT, LLC | 223,700 | 4,979,562 | 1.34% | ||
| 18 | NORTHERN TRUST CORP | 185,152 | 4,122,000 | 1.11% | ||
| 19 | OXFORD ASSET MANAGEMENT LLP | 155,077 | 3,530,000 | 0.95% | ||
| 20 | UBS Group AG | 143,012 | 3,183,000 | 0.86% | ||
| 21 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 133,074 | 2,962,000 | 0.80% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 125,569 | 2,795,000 | 0.75% | ||
| 23 | Invesco Ltd. | 125,478 | 2,793,000 | 0.75% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 124,612 | 2,774,000 | 0.75% | ||
| 25 | TIVERTON ASSET MANAGEMENT LLC | 120,555 | 2,684,000 | 0.72% | ||
| 26 | JPMORGAN CHASE & CO | 109,500 | 2,438,000 | 0.66% | ||
| 27 | A.R.T. Advisors, LLC | 103,746 | 2,309,000 | 0.62% | ||
| 28 | Tekla Capital Management LLC | 102,800 | 2,288,000 | 0.62% | ||
| 29 | Rhenman & Partners Asset Management AB | 100,000 | 2,226,000 | 0.60% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 96,609 | 2,151,000 | 0.58% | ||
| 31 | PRICE T ROWE ASSOCIATES INC /MD/ | 96,585 | 2,150,000 | 0.58% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 94,000 | 2,092,000 | 0.56% | Put | |
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 91,184 | 2,029,000 | 0.55% | ||
| 34 | CREDIT SUISSE AG/ | 80,574 | 1,793,000 | 0.48% | ||
| 35 | Candriam S.C.A. | 75,000 | 1,670,000 | 0.45% | ||
| 36 | GAM Holding AG | 64,000 | 1,425,000 | 0.38% | ||
| 37 | Bank of New York Mellon Corp | 61,790 | 1,376,000 | 0.37% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,021 | 1,225,000 | 0.33% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 54,000 | 1,202,000 | 0.32% | ||
| 40 | GOLDMAN SACHS GROUP INC | 53,300 | 1,186,000 | 0.32% | Call | |
| 41 | Telemetry Investments, L.L.C. | 52,000 | 1,158,000 | 0.31% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,900 | 1,155,000 | 0.31% | Call | |
| 43 | GOLDMAN SACHS GROUP INC | 50,900 | 1,133,000 | 0.30% | Put | |
| 44 | Trexquant Investment LP | 50,800 | 1,131,000 | 0.30% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,549 | 1,014,000 | 0.27% | ||
| 46 | BlackRock Investment Management, LLC | 44,173 | 983,000 | 0.26% | ||
| 47 | GOLDMAN SACHS GROUP INC | 42,031 | 936,000 | 0.25% | ||
| 48 | CITIGROUP INC | 40,736 | 906,000 | 0.24% | ||
| 49 | BELLEVUE ASSET MANAGEMENT AG | 40,000 | 890,000 | 0.24% | ||
| 50 | Glacier Peak Capital LLC | 38,048 | 847,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
