| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,536,271 | 59,831,000 | 14.53% | ||
| 2 | Aisling Capital LLC | 1,637,125 | 38,620,000 | 9.38% | ||
| 3 | Pentwater Capital Management LP | 1,450,000 | 34,206,000 | 8.31% | ||
| 4 | BB BIOTECH AG | 908,542 | 21,433,000 | 5.21% | ||
| 5 | COLUMBUS CIRCLE INVESTORS | 738,911 | 17,431,000 | 4.23% | ||
| 6 | STATE STREET CORP | 727,877 | 17,174,000 | 4.17% | ||
| 7 | VANGUARD GROUP INC | 727,260 | 17,156,000 | 4.17% | ||
| 8 | WASATCH ADVISORS LP | 690,373 | 16,286,000 | 3.96% | ||
| 9 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 524,200 | 12,366,000 | 3.00% | ||
| 10 | DEUTSCHE BANK AG\ | 488,018 | 11,510,000 | 2.80% | ||
| 11 | Sarissa Capital Management LP | 448,000 | 10,568,000 | 2.57% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 370,000 | 8,728,000 | 2.12% | Put | |
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 348,100 | 8,212,000 | 1.99% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 320,172 | 7,553,000 | 1.83% | ||
| 15 | BlackRock Fund Advisors | 313,457 | 7,394,000 | 1.80% | ||
| 16 | Polar Capital LLP | 309,456 | 7,300,000 | 1.77% | ||
| 17 | Granahan Investment Management, LLC | 299,580 | 7,067,000 | 1.72% | ||
| 18 | VOYA INVESTMENT MANAGEMENT LLC | 279,067 | 6,584,000 | 1.60% | ||
| 19 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 236,669 | 5,583,000 | 1.36% | ||
| 20 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 214,162 | 5,052,000 | 1.23% | ||
| 21 | JPMORGAN CHASE & CO | 204,331 | 4,821,000 | 1.17% | ||
| 22 | NORTHERN TRUST CORP | 180,424 | 4,257,000 | 1.03% | ||
| 23 | CITADEL ADVISORS LLC | 173,114 | 4,083,000 | 0.99% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 161,800 | 3,817,000 | 0.93% | Call | |
| 25 | BANK OF AMERICA CORP /DE/ | 147,864 | 3,488,000 | 0.85% | ||
| 26 | TIVERTON ASSET MANAGEMENT LLC | 135,555 | 3,198,000 | 0.78% | ||
| 27 | Invesco Ltd. | 122,337 | 2,886,000 | 0.70% | ||
| 28 | AXA S.A. | 117,703 | 2,777,000 | 0.67% | ||
| 29 | Tekla Capital Management LLC | 102,800 | 2,425,000 | 0.59% | ||
| 30 | Tekla Capital Management LLC | 102,800 | 2,425,000 | 0.59% | Call | |
| 31 | Allianz Asset Management GmbH | 102,020 | 2,407,000 | 0.58% | ||
| 32 | Candriam S.C.A. | 100,800 | 2,378,000 | 0.58% | ||
| 33 | Rhenman & Partners Asset Management AB | 100,000 | 2,359,000 | 0.57% | ||
| 34 | GOLDMAN SACHS GROUP INC | 98,100 | 2,314,000 | 0.56% | Call | |
| 35 | PRICE T ROWE ASSOCIATES INC /MD/ | 89,272 | 2,106,000 | 0.51% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 88,322 | 2,083,000 | 0.51% | ||
| 37 | Point72 Asset Management, L.P. | 77,000 | 1,816,000 | 0.44% | ||
| 38 | RUSSELL FRANK CO/ | 70,904 | 1,673,000 | 0.41% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 64,100 | 1,512,000 | 0.37% | ||
| 40 | GAM Holding AG | 64,000 | 1,510,000 | 0.37% | ||
| 41 | UBS Group AG | 62,797 | 1,482,000 | 0.36% | ||
| 42 | Bank of New York Mellon Corp | 60,370 | 1,424,000 | 0.35% | ||
| 43 | AQR CAPITAL MANAGEMENT LLC | 60,167 | 1,419,000 | 0.34% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,596 | 1,312,000 | 0.32% | ||
| 45 | GLG Partners LP | 53,912 | 1,272,000 | 0.31% | ||
| 46 | Trexquant Investment LP | 50,900 | 1,200,000 | 0.29% | ||
| 47 | Iguana Healthcare Management, LLC | 50,000 | 1,180,000 | 0.29% | ||
| 48 | CREDIT SUISSE AG/ | 49,551 | 1,169,000 | 0.28% | ||
| 49 | First Light Asset Management, LLC | 47,965 | 1,131,000 | 0.27% | ||
| 50 | Mirae Asset Global Investments Co., Ltd. | 47,500 | 1,121,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
