| 1 |
FMR LLC |
1,943,964 |
7,834,000 |
22.83% |
|
|
| 2 |
FEDERATED HERMES, INC. |
1,233,360 |
4,970,000 |
14.48% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
848,000 |
3,417,000 |
9.96% |
|
|
| 4 |
Broadfin Capital, LLC |
753,373 |
3,036,000 |
8.85% |
|
|
| 5 |
Rock Springs Capital Management LP |
635,000 |
2,559,000 |
7.46% |
|
|
| 6 |
Foresite Capital Management II, LLC |
337,177 |
1,359,000 |
3.96% |
|
|
| 7 |
Visium Asset Management, LP |
335,000 |
1,350,000 |
3.93% |
|
|
| 8 |
JENNISON ASSOCIATES LLC |
320,780 |
1,293,000 |
3.77% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
304,600 |
1,228,000 |
3.58% |
|
|
| 10 |
Sio Capital Management, LLC |
284,556 |
1,147,000 |
3.34% |
|
|
| 11 |
PRINCIPAL FINANCIAL GROUP INC |
208,438 |
840,000 |
2.45% |
|
|
| 12 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
200,000 |
806,000 |
2.35% |
|
|
| 13 |
AWM Investment Company, Inc. |
186,608 |
752,000 |
2.19% |
|
|
| 14 |
PERCEPTIVE ADVISORS LLC |
175,000 |
705,000 |
2.05% |
|
|
| 15 |
VANGUARD GROUP INC |
168,718 |
680,000 |
1.98% |
|
|
| 16 |
DAFNA Capital Management LLC |
156,904 |
632,000 |
1.84% |
|
|
| 17 |
Iguana Healthcare Management, LLC |
125,000 |
504,000 |
1.47% |
|
|
| 18 |
Private Advisor Group, LLC |
100,000 |
403,000 |
1.17% |
|
|
| 19 |
FT OPTIONS LLC |
55,130 |
222,000 |
0.65% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
55,168 |
222,000 |
0.65% |
|
|
| 21 |
DEUTSCHE BANK AG\ |
44,649 |
179,000 |
0.52% |
|
|
| 22 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
27,500 |
111,000 |
0.32% |
|
|
| 23 |
ROYAL BANK OF CANADA |
5,300 |
21,000 |
0.06% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
4,201 |
17,000 |
0.05% |
|
|
| 25 |
UBS Group AG |
2,897 |
12,000 |
0.03% |
|
|
| 26 |
BlackRock Fund Advisors |
2,288 |
9,000 |
0.03% |
|
|
| 27 |
BlackRock Investment Management, LLC |
2,041 |
8,000 |
0.02% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
1,122 |
4,000 |
0.01% |
|
|
| 29 |
BANK OF AMERICA CORP /DE/ |
550 |
2,000 |
0.01% |
|
|
| 30 |
MORGAN STANLEY |
21 |
0 |
0.00% |
|
|
