| 1 |
FMR LLC |
1,821,100 |
11,309,000 |
21.35% |
|
|
| 2 |
FEDERATED HERMES, INC. |
1,233,360 |
7,659,000 |
14.46% |
|
|
| 3 |
Broadfin Capital, LLC |
775,000 |
4,813,000 |
9.09% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
696,281 |
4,324,000 |
8.16% |
|
|
| 5 |
Rock Springs Capital Management LP |
635,000 |
3,943,000 |
7.44% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
599,759 |
3,725,000 |
7.03% |
|
|
| 7 |
Foresite Capital Management II, LLC |
337,177 |
2,094,000 |
3.95% |
|
|
| 8 |
Visium Asset Management, LP |
325,389 |
2,021,000 |
3.82% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
304,600 |
1,892,000 |
3.57% |
|
|
| 10 |
AWM Investment Company, Inc. |
299,687 |
1,861,000 |
3.51% |
|
|
| 11 |
PRINCIPAL FINANCIAL GROUP INC |
208,438 |
1,294,000 |
2.44% |
|
|
| 12 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
200,000 |
1,242,000 |
2.34% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
175,000 |
1,087,000 |
2.05% |
|
|
| 14 |
VANGUARD GROUP INC |
168,718 |
1,048,000 |
1.98% |
|
|
| 15 |
Sio Capital Management, LLC |
162,175 |
1,007,000 |
1.90% |
|
|
| 16 |
DAFNA Capital Management LLC |
156,904 |
974,000 |
1.84% |
|
SH |
| 17 |
Iguana Healthcare Management, LLC |
125,000 |
776,000 |
1.46% |
|
|
| 18 |
Private Advisor Group, LLC |
100,000 |
621,000 |
1.17% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
55,168 |
342,000 |
0.65% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
44,649 |
277,000 |
0.52% |
|
|
| 21 |
NEXTHERA CAPITAL LP |
39,693 |
246,000 |
0.46% |
|
|
| 22 |
FT OPTIONS LLC |
37,875 |
235,000 |
0.44% |
|
|
| 23 |
Spark Investment Management LLC |
16,200 |
100,000 |
0.19% |
|
|
| 24 |
ROYAL BANK OF CANADA |
5,300 |
33,000 |
0.06% |
|
|
| 25 |
BlackRock Institutional Trust Company, N.A. |
4,201 |
26,000 |
0.05% |
|
|
| 26 |
BlackRock Investment Management, LLC |
2,041 |
13,000 |
0.02% |
|
|
| 27 |
BlackRock Fund Advisors |
1,826 |
11,000 |
0.02% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
156 |
1,000 |
0.00% |
|
|
