| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 3,408,360 | 10,873,000 | 29.79% | ||
| 2 | Broadfin Capital, LLC | 1,477,273 | 4,713,000 | 12.91% | ||
| 3 | FMR LLC | 1,331,989 | 4,249,000 | 11.64% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,048,000 | 3,343,000 | 9.16% | ||
| 5 | Rock Springs Capital Management LP | 760,000 | 2,424,000 | 6.64% | ||
| 6 | VANGUARD GROUP INC | 595,746 | 1,901,000 | 5.21% | ||
| 7 | BAKER BROS. ADVISORS LP | 467,600 | 1,492,000 | 4.09% | ||
| 8 | HIGHLAND CAPITAL MANAGEMENT LP | 413,746 | 1,320,000 | 3.62% | ||
| 9 | Iguana Healthcare Management, LLC | 250,000 | 798,000 | 2.19% | ||
| 10 | PRINCIPAL FINANCIAL GROUP INC | 202,938 | 647,000 | 1.77% | ||
| 11 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 200,000 | 638,000 | 1.75% | ||
| 12 | DAFNA Capital Management LLC | 173,645 | 554,000 | 1.52% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 171,185 | 546,000 | 1.50% | ||
| 14 | Granite Point Capital Management, L.P. | 157,500 | 502,000 | 1.38% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 128,724 | 410,000 | 1.12% | ||
| 16 | AWM Investment Company, Inc. | 125,000 | 399,000 | 1.09% | ||
| 17 | FT OPTIONS LLC | 119,905 | 382,000 | 1.05% | ||
| 18 | DEUTSCHE BANK AG\ | 72,349 | 230,000 | 0.63% | ||
| 19 | BlackRock Fund Advisors | 70,370 | 224,000 | 0.61% | ||
| 20 | GAINPLAN LLC | 62,000 | 198,000 | 0.54% | ||
| 21 | NORTHERN TRUST CORP | 45,118 | 144,000 | 0.39% | ||
| 22 | Bank of New York Mellon Corp | 37,011 | 118,000 | 0.32% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 23,277 | 74,000 | 0.20% | ||
| 24 | TFS CAPITAL LLC | 18,655 | 60,000 | 0.16% | ||
| 25 | ROYAL BANK OF CANADA | 13,300 | 42,000 | 0.12% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 12,483 | 40,000 | 0.11% | ||
| 27 | RBF Capital, LLC | 11,100 | 37,000 | 0.10% | ||
| 28 | AMERIPRISE FINANCIAL INC | 10,200 | 33,000 | 0.09% | ||
| 29 | BlackRock Institutional Trust Company, N.A. | 8,102 | 26,000 | 0.07% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 7,550 | 24,000 | 0.07% | ||
| 31 | UBS Group AG | 6,546 | 21,000 | 0.06% | ||
| 32 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 3,156 | 12,000 | 0.03% | ||
| 33 | BlackRock Investment Management, LLC | 3,496 | 11,000 | 0.03% | ||
| 34 | Creative Planning | 2,000 | 6,000 | 0.02% | ||
| 35 | US BANCORP \DE\ | 500 | 2,000 | 0.01% | ||
| 36 | KRILOGY FINANCIAL LLC | 300 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
