| 1 |
FEDERATED HERMES, INC. |
3,408,360 |
13,190,000 |
29.77% |
|
|
| 2 |
Broadfin Capital, LLC |
1,477,273 |
5,717,000 |
12.91% |
|
|
| 3 |
FMR LLC |
1,344,546 |
5,203,000 |
11.74% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,048,000 |
4,056,000 |
9.16% |
|
|
| 5 |
Rock Springs Capital Management LP |
635,000 |
2,457,000 |
5.55% |
|
|
| 6 |
VANGUARD GROUP INC |
584,393 |
2,261,000 |
5.10% |
|
|
| 7 |
HIGHLAND CAPITAL MANAGEMENT LP |
474,770 |
1,837,000 |
4.15% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
467,600 |
1,810,000 |
4.09% |
|
|
| 9 |
DAFNA Capital Management LLC |
213,250 |
825,000 |
1.86% |
|
|
| 10 |
PRINCIPAL FINANCIAL GROUP INC |
202,938 |
785,000 |
1.77% |
|
|
| 11 |
Private Advisor Group, LLC |
201,140 |
779,000 |
1.76% |
|
|
| 12 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
200,000 |
774,000 |
1.75% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
171,185 |
662,000 |
1.49% |
|
|
| 14 |
Granite Point Capital Management, L.P. |
157,500 |
610,000 |
1.38% |
|
|
| 15 |
FT OPTIONS LLC |
130,733 |
506,000 |
1.14% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
128,724 |
498,000 |
1.12% |
|
|
| 17 |
AWM Investment Company, Inc. |
125,000 |
484,000 |
1.09% |
|
|
| 18 |
Iguana Healthcare Management, LLC |
125,000 |
484,000 |
1.09% |
|
|
| 19 |
DEUTSCHE BANK AG\ |
97,349 |
376,000 |
0.85% |
|
|
| 20 |
BlackRock Fund Advisors |
64,514 |
250,000 |
0.56% |
|
|
| 21 |
Bank of New York Mellon Corp |
41,494 |
161,000 |
0.36% |
|
|
| 22 |
NORTHERN TRUST CORP |
40,882 |
158,000 |
0.36% |
|
|
| 23 |
MILLENNIUM MANAGEMENT LLC |
35,876 |
139,000 |
0.31% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
12,666 |
49,000 |
0.11% |
|
|
| 25 |
PANAGORA ASSET MANAGEMENT INC |
12,483 |
48,000 |
0.11% |
|
|
| 26 |
RBF Capital, LLC |
11,100 |
43,000 |
0.10% |
|
|
| 27 |
ROYAL BANK OF CANADA |
9,300 |
36,000 |
0.08% |
|
|
| 28 |
Creative Planning |
8,300 |
32,000 |
0.07% |
|
|
| 29 |
BANK OF AMERICA CORP /DE/ |
6,608 |
25,000 |
0.06% |
|
|
| 30 |
BlackRock Investment Management, LLC |
3,496 |
14,000 |
0.03% |
|
|
| 31 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
3,156 |
14,000 |
0.03% |
|
|
| 32 |
MORGAN STANLEY |
2,000 |
8,000 |
0.02% |
|
|
| 33 |
UBS Group AG |
1,804 |
7,000 |
0.02% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
216 |
1,000 |
0.00% |
|
|
| 35 |
KRILOGY FINANCIAL LLC |
300 |
1,000 |
0.00% |
|
|
