| 1 |
FMR LLC |
1,821,100 |
13,258,000 |
22.15% |
|
|
| 2 |
FEDERATED HERMES, INC. |
1,233,360 |
8,979,000 |
15.00% |
|
|
| 3 |
Broadfin Capital, LLC |
775,000 |
5,642,000 |
9.43% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
692,781 |
5,043,000 |
8.42% |
|
|
| 5 |
JENNISON ASSOCIATES LLC |
598,371 |
4,356,000 |
7.28% |
|
|
| 6 |
Rock Springs Capital Management LP |
470,000 |
3,422,000 |
5.72% |
|
|
| 7 |
Foresite Capital Management II, LLC |
337,177 |
2,455,000 |
4.10% |
|
|
| 8 |
SPHERA FUNDS MANAGEMENT LTD. |
313,000 |
2,279,000 |
3.81% |
|
|
| 9 |
AWM Investment Company, Inc. |
305,200 |
2,222,000 |
3.71% |
|
|
| 10 |
PRINCIPAL FINANCIAL GROUP INC |
208,438 |
1,517,000 |
2.53% |
|
|
| 11 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
200,000 |
1,456,000 |
2.43% |
|
|
| 12 |
Visium Asset Management, LP |
180,000 |
1,310,000 |
2.19% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
175,000 |
1,274,000 |
2.13% |
|
|
| 14 |
VANGUARD GROUP INC |
168,118 |
1,224,000 |
2.04% |
|
|
| 15 |
Sio Capital Management, LLC |
162,175 |
1,181,000 |
1.97% |
|
|
| 16 |
DAFNA Capital Management LLC |
156,904 |
1,142,000 |
1.91% |
|
SH |
| 17 |
Iguana Healthcare Management, LLC |
125,000 |
910,000 |
1.52% |
|
|
| 18 |
Cormorant Asset Management, LP |
99,366 |
723,000 |
1.21% |
|
|
| 19 |
Private Advisor Group, LLC |
77,267 |
563,000 |
0.94% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
55,168 |
401,000 |
0.67% |
|
|
| 21 |
DEUTSCHE BANK AG\ |
44,649 |
325,000 |
0.54% |
|
|
| 22 |
Spark Investment Management LLC |
18,300 |
120,000 |
0.20% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
3,248 |
24,000 |
0.04% |
|
|
| 24 |
ROYAL BANK OF CANADA |
2,300 |
17,000 |
0.03% |
|
|
| 25 |
BlackRock Investment Management, LLC |
1,905 |
14,000 |
0.02% |
|
|
| 26 |
Tower Research Capital LLC (TRC) |
259 |
2,000 |
0.00% |
|
|
