| 1 |
FMR LLC |
1,821,100 |
16,007,000 |
22.36% |
|
|
| 2 |
FEDERATED HERMES, INC. |
1,229,100 |
10,804,000 |
15.09% |
|
|
| 3 |
Broadfin Capital, LLC |
775,000 |
6,812,000 |
9.52% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
692,781 |
6,090,000 |
8.51% |
|
|
| 5 |
Foresite Capital Management II, LLC |
628,155 |
5,521,000 |
7.71% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
596,507 |
5,243,000 |
7.32% |
|
|
| 7 |
SPHERA FUNDS MANAGEMENT LTD. |
313,000 |
2,751,000 |
3.84% |
|
|
| 8 |
AWM Investment Company, Inc. |
305,200 |
2,683,000 |
3.75% |
|
|
| 9 |
PRINCIPAL FINANCIAL GROUP INC |
208,438 |
1,832,000 |
2.56% |
|
|
| 10 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
200,000 |
1,758,000 |
2.46% |
|
|
| 11 |
Visium Asset Management, LP |
180,000 |
1,582,000 |
2.21% |
|
|
| 12 |
Rock Springs Capital Management LP |
176,000 |
1,547,000 |
2.16% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
175,000 |
1,538,000 |
2.15% |
|
|
| 14 |
VANGUARD GROUP INC |
165,804 |
1,458,000 |
2.04% |
|
|
| 15 |
Sio Capital Management, LLC |
162,175 |
1,426,000 |
1.99% |
|
|
| 16 |
DAFNA Capital Management LLC |
161,382 |
1,419,000 |
1.98% |
|
SH |
| 17 |
Iguana Healthcare Management, LLC |
125,000 |
1,099,000 |
1.54% |
|
|
| 18 |
Cormorant Asset Management, LP |
99,366 |
873,000 |
1.22% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
55,168 |
484,000 |
0.68% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
44,649 |
392,000 |
0.55% |
|
|
| 21 |
Spark Investment Management LLC |
23,500 |
205,000 |
0.29% |
|
|
| 22 |
UBS Group AG |
2,206 |
19,000 |
0.03% |
|
|
| 23 |
ROYAL BANK OF CANADA |
2,000 |
18,000 |
0.03% |
|
|
| 24 |
BlackRock Investment Management, LLC |
1,905 |
17,000 |
0.02% |
|
|
| 25 |
BlackRock Institutional Trust Company, N.A. |
1,177 |
10,000 |
0.01% |
|
|
| 26 |
USA MUTUALS ADVISORS, INC. |
190 |
2,000 |
0.00% |
|
|
| 27 |
Tower Research Capital LLC (TRC) |
100 |
1,000 |
0.00% |
|
|
| 28 |
MORGAN STANLEY |
15 |
0 |
0.00% |
|
|
