| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 14,083,582 | 71,826,000 | 37.76% | ||
| 2 | FMR LLC | 2,558,389 | 13,048,000 | 6.86% | ||
| 3 | BlackRock Finance, Inc. | 2,494,119 | 12,719,000 | 6.69% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,279,780 | 11,627,000 | 6.11% | ||
| 5 | Rock Springs Capital Management LP | 2,000,000 | 10,200,000 | 5.36% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,810,581 | 9,233,000 | 4.85% | ||
| 7 | Cormorant Asset Management, LP | 1,422,738 | 7,256,000 | 3.81% | SH | |
| 8 | VANGUARD GROUP INC | 1,277,634 | 6,516,000 | 3.43% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,013,501 | 5,169,000 | 2.72% | ||
| 10 | MARSHALL WACE NORTH AMERICA, L.P. | 807,246 | 4,036,000 | 2.12% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 670,617 | 3,420,000 | 1.80% | ||
| 12 | Tekla Capital Management LLC | 639,370 | 3,261,000 | 1.71% | ||
| 13 | FIRST MANHATTAN CO. LLC. | 621,928 | 3,171,000 | 1.67% | ||
| 14 | Opaleye Management Inc. | 546,500 | 2,787,000 | 1.47% | ||
| 15 | STATE STREET CORP | 507,918 | 2,592,000 | 1.36% | ||
| 16 | DAFNA Capital Management LLC | 373,409 | 1,904,000 | 1.00% | ||
| 17 | NORTHERN TRUST CORP | 367,753 | 1,876,000 | 0.99% | ||
| 18 | SPHERA FUNDS MANAGEMENT LTD. | 345,000 | 1,760,000 | 0.93% | ||
| 19 | TEACHERS ADVISORS, LLC | 314,562 | 1,604,000 | 0.84% | ||
| 20 | DIMENSIONAL FUND ADVISORS LP | 259,202 | 1,322,000 | 0.70% | ||
| 21 | D. E. Shaw & Co., Inc. | 255,735 | 1,304,000 | 0.69% | ||
| 22 | KENNEDY CAPITAL MANAGEMENT LLC | 249,864 | 1,274,000 | 0.67% | ||
| 23 | Crestline Management, LP | 211,727 | 1,080,000 | 0.57% | ||
| 24 | MORGAN STANLEY | 192,265 | 981,000 | 0.52% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 185,378 | 945,000 | 0.50% | ||
| 26 | Bank of New York Mellon Corp | 144,799 | 739,000 | 0.39% | ||
| 27 | AXIOM INVESTORS LLC /DE | 110,654 | 564,000 | 0.30% | ||
| 28 | AWM Investment Company, Inc. | 100,000 | 510,000 | 0.27% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 84,243 | 430,000 | 0.23% | ||
| 30 | ClariVest Asset Management LLC | 66,900 | 341,000 | 0.18% | ||
| 31 | Connor, Clark & Lunn Investment Management Ltd. | 66,106 | 337,000 | 0.18% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 64,340 | 329,000 | 0.17% | ||
| 33 | GOLDMAN SACHS GROUP INC | 61,139 | 312,000 | 0.16% | ||
| 34 | ALLIANCEBERNSTEIN L.P. | 60,500 | 309,000 | 0.16% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 59,197 | 302,000 | 0.16% | ||
| 36 | Trexquant Investment LP | 51,334 | 262,000 | 0.14% | ||
| 37 | CITADEL ADVISORS LLC | 48,540 | 248,000 | 0.13% | ||
| 38 | Swiss National Bank | 46,600 | 238,000 | 0.13% | ||
| 39 | DEUTSCHE BANK AG\ | 46,047 | 234,000 | 0.12% | ||
| 40 | RHUMBLINE ADVISERS | 40,516 | 207,000 | 0.11% | ||
| 41 | Walleye Trading LLC | 38,887 | 198,000 | 0.10% | ||
| 42 | Foresite Capital Management II, LLC | 37,500 | 191,000 | 0.10% | ||
| 43 | FORESITE CAPITAL MANAGEMENT III, LLC | 37,500 | 191,000 | 0.10% | ||
| 44 | IndexIQ Advisors LLC | 37,413 | 191,000 | 0.10% | ||
| 45 | Spark Investment Management LLC | 33,500 | 170,000 | 0.09% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 32,800 | 167,000 | 0.09% | ||
| 47 | TFS CAPITAL LLC | 32,154 | 164,000 | 0.09% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,252 | 159,000 | 0.08% | ||
| 49 | TD ASSET MANAGEMENT INC | 27,708 | 141,000 | 0.07% | ||
| 50 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 27,581 | 141,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
