| 1 |
Versant Venture Management, LLC |
1,048,601 |
2,820,736 |
15.54% |
|
|
| 2 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,000,000 |
2,690,000 |
14.82% |
|
|
| 3 |
JENNISON ASSOCIATES LLC |
858,786 |
2,310,000 |
12.72% |
|
|
| 4 |
Lombard Odier Asset Management (USA) Corp |
742,126 |
1,996,000 |
10.99% |
|
|
| 5 |
Point72 Asset Management, L.P. |
585,288 |
1,574,000 |
8.67% |
|
|
| 6 |
Visium Asset Management, LP |
550,948 |
1,482,000 |
8.16% |
|
|
| 7 |
EverPoint Asset Management, LLC |
468,099 |
1,259,000 |
6.93% |
|
|
| 8 |
VANGUARD GROUP INC |
332,307 |
894,000 |
4.92% |
|
|
| 9 |
Iguana Healthcare Management, LLC |
240,000 |
646,000 |
3.56% |
|
|
| 10 |
ALLIANCEBERNSTEIN L.P. |
234,974 |
632,000 |
3.48% |
|
|
| 11 |
PURA VIDA INVESTMENTS, LLC |
200,000 |
602,000 |
3.32% |
|
|
| 12 |
SABBY MANAGEMENT, LLC |
100,000 |
269,000 |
1.48% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
49,022 |
131,000 |
0.72% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
46,238 |
124,000 |
0.68% |
|
|
| 15 |
BNP PARIBAS FINANCIAL MARKETS |
45,000 |
121,050 |
0.67% |
|
|
| 16 |
BlackRock Fund Advisors |
37,834 |
102,000 |
0.56% |
|
|
| 17 |
A.R.T. Advisors, LLC |
36,069 |
97,000 |
0.53% |
|
|
| 18 |
PDT Partners, LLC |
27,900 |
75,000 |
0.41% |
|
|
| 19 |
JPMORGAN CHASE & CO |
25,000 |
67,000 |
0.37% |
|
|
| 20 |
Parallax Volatility Advisers, L.P. |
23,400 |
63,000 |
0.35% |
|
|
| 21 |
Alpha Cubed Investments, LLC |
20,000 |
54,000 |
0.30% |
|
|
| 22 |
NORTHERN TRUST CORP |
14,986 |
40,000 |
0.22% |
|
|
| 23 |
BALYASNY ASSET MANAGEMENT L.P. |
14,315 |
39,000 |
0.21% |
|
|
| 24 |
Spark Investment Management LLC |
11,300 |
30,000 |
0.17% |
|
|
| 25 |
UBS Group AG |
6,771 |
18,000 |
0.10% |
|
|
| 26 |
MORGAN STANLEY |
2,568 |
7,000 |
0.04% |
|
|
| 27 |
BlackRock Investment Management, LLC |
2,239 |
6,000 |
0.03% |
|
|
| 28 |
BANK OF AMERICA CORP /DE/ |
2,200 |
6,000 |
0.03% |
|
|
| 29 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
257 |
1,000 |
0.01% |
|
|
