| 1 |
Abingworth LLP |
1,600,000 |
3,104,000 |
24.50% |
|
|
| 2 |
Versant Venture Management, LLC |
1,048,601 |
2,034,286 |
16.05% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
958,822 |
1,860,000 |
14.68% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
700,000 |
1,358,000 |
10.72% |
|
|
| 5 |
Lombard Odier Asset Management (USA) Corp |
626,978 |
1,216,000 |
9.60% |
|
|
| 6 |
VANGUARD GROUP INC |
614,705 |
1,192,000 |
9.41% |
|
|
| 7 |
Omega Fund Management, LLC |
301,477 |
585,000 |
4.62% |
|
|
| 8 |
ALLIANCEBERNSTEIN L.P. |
210,731 |
409,000 |
3.23% |
|
|
| 9 |
RENAISSANCE TECHNOLOGIES LLC |
120,800 |
234,000 |
1.85% |
|
|
| 10 |
GEODE CAPITAL MANAGEMENT, LLC |
98,296 |
190,000 |
1.50% |
|
|
| 11 |
BlackRock Fund Advisors |
65,846 |
128,000 |
1.01% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
46,238 |
90,000 |
0.71% |
|
|
| 13 |
NORTHERN TRUST CORP |
30,116 |
58,000 |
0.46% |
|
|
| 14 |
Alpha Cubed Investments, LLC |
20,000 |
39,000 |
0.31% |
|
|
| 15 |
Bank of New York Mellon Corp |
18,283 |
35,000 |
0.28% |
|
|
| 16 |
Virtu KCG Holdings LLC |
17,208 |
33,000 |
0.26% |
|
|
| 17 |
GOLDMAN SACHS GROUP INC |
16,554 |
32,000 |
0.25% |
|
|
| 18 |
CITADEL ADVISORS LLC |
12,692 |
25,000 |
0.20% |
|
|
| 19 |
BARCLAYS PLC |
11,500 |
22,000 |
0.17% |
|
|
| 20 |
BlackRock Investment Management, LLC |
3,841 |
7,000 |
0.06% |
|
|
| 21 |
UBS Group AG |
3,000 |
6,000 |
0.05% |
|
|
| 22 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
2,600 |
5,000 |
0.04% |
|
|
| 23 |
Parallax Volatility Advisers, L.P. |
1,764 |
3,000 |
0.02% |
|
|
| 24 |
MORGAN STANLEY |
1,400 |
3,000 |
0.02% |
|
|
| 25 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
257 |
1,000 |
0.01% |
|
|
| 26 |
Tower Research Capital LLC (TRC) |
387 |
1,000 |
0.01% |
|
|
| 27 |
BANK OF AMERICA CORP /DE/ |
415 |
1,000 |
0.01% |
|
|
