| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,700,000 |
2,295,000 |
18.71% |
|
|
| 2 |
Abingworth LLP |
1,600,000 |
2,160,000 |
17.61% |
|
|
| 3 |
Versant Venture Management, LLC |
1,048,601 |
1,415,611 |
11.54% |
|
|
| 4 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
958,920 |
1,295,000 |
10.56% |
|
|
| 5 |
Point72 Asset Management, L.P. |
843,800 |
1,139,000 |
9.29% |
|
|
| 6 |
Lombard Odier Asset Management (USA) Corp |
709,440 |
958,000 |
7.81% |
|
|
| 7 |
Omega Fund Management, LLC |
606,100 |
818,000 |
6.67% |
|
|
| 8 |
VANGUARD GROUP INC |
549,353 |
742,000 |
6.05% |
|
|
| 9 |
J. Goldman & Co LP |
239,260 |
323,000 |
2.63% |
|
|
| 10 |
ALLIANCEBERNSTEIN L.P. |
234,974 |
317,000 |
2.58% |
|
|
| 11 |
RENAISSANCE TECHNOLOGIES LLC |
111,000 |
150,000 |
1.22% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
98,296 |
132,000 |
1.08% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
67,534 |
91,000 |
0.74% |
|
|
| 14 |
PURA VIDA INVESTMENTS, LLC |
56,000 |
76,000 |
0.62% |
|
|
| 15 |
BlackRock Fund Advisors |
50,011 |
68,000 |
0.55% |
|
|
| 16 |
BlackRock Institutional Trust Company, N.A. |
46,238 |
62,000 |
0.51% |
|
|
| 17 |
NORTHERN TRUST CORP |
30,116 |
41,000 |
0.33% |
|
|
| 18 |
Hoxton Financial, Inc. |
25,920 |
35,000 |
0.29% |
|
|
| 19 |
Parallax Volatility Advisers, L.P. |
25,274 |
34,000 |
0.28% |
|
|
| 20 |
Bank of New York Mellon Corp |
21,379 |
29,000 |
0.24% |
|
|
| 21 |
Alpha Cubed Investments, LLC |
20,000 |
27,000 |
0.22% |
|
|
| 22 |
Raymond James Financial Services Advisors, Inc. |
19,744 |
27,000 |
0.22% |
|
|
| 23 |
CITADEL ADVISORS LLC |
10,979 |
15,000 |
0.12% |
|
|
| 24 |
Tower Research Capital LLC (TRC) |
5,777 |
8,000 |
0.07% |
|
|
| 25 |
BlackRock Investment Management, LLC |
3,566 |
5,000 |
0.04% |
|
|
| 26 |
BANK OF AMERICA CORP /DE/ |
2,200 |
3,000 |
0.02% |
|
|
| 27 |
BARCLAYS PLC |
1,300 |
1,000 |
0.01% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
68 |
0 |
0.00% |
|
|
| 29 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
257 |
0 |
0.00% |
|
|
| 30 |
MORGAN STANLEY |
150 |
0 |
0.00% |
|
|
| 31 |
CITIGROUP INC |
324 |
0 |
0.00% |
|
|
