| 1 |
Abingworth LLP |
1,600,000 |
2,800,000 |
22.57% |
|
|
| 2 |
Versant Venture Management, LLC |
1,048,601 |
1,824,566 |
14.71% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
958,822 |
1,668,000 |
13.45% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
919,200 |
1,599,000 |
12.89% |
|
|
| 5 |
Lombard Odier Asset Management (USA) Corp |
653,216 |
1,137,000 |
9.17% |
|
|
| 6 |
VANGUARD GROUP INC |
612,249 |
1,065,000 |
8.58% |
|
|
| 7 |
Omega Fund Management, LLC |
606,100 |
1,055,000 |
8.50% |
|
|
| 8 |
ALLIANCEBERNSTEIN L.P. |
234,974 |
409,000 |
3.30% |
|
|
| 9 |
RENAISSANCE TECHNOLOGIES LLC |
128,300 |
223,000 |
1.80% |
|
|
| 10 |
GEODE CAPITAL MANAGEMENT, LLC |
98,296 |
171,000 |
1.38% |
|
|
| 11 |
BlackRock Fund Advisors |
66,072 |
115,000 |
0.93% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
46,238 |
80,000 |
0.64% |
|
|
| 13 |
UNITED CAPITAL FINANCIAL ADVISORS, LLC |
25,920 |
52,000 |
0.42% |
|
|
| 14 |
NORTHERN TRUST CORP |
30,116 |
52,000 |
0.42% |
|
|
| 15 |
CITADEL ADVISORS LLC |
27,050 |
47,000 |
0.38% |
|
|
| 16 |
Bank of New York Mellon Corp |
21,879 |
38,000 |
0.31% |
|
|
| 17 |
Alpha Cubed Investments, LLC |
20,000 |
35,000 |
0.28% |
|
|
| 18 |
Parallax Volatility Advisers, L.P. |
7,374 |
13,000 |
0.10% |
|
|
| 19 |
UBS Group AG |
6,128 |
10,000 |
0.08% |
|
|
| 20 |
BlackRock Investment Management, LLC |
3,566 |
6,000 |
0.05% |
|
|
| 21 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
2,900 |
5,000 |
0.04% |
|
|
| 22 |
MORGAN STANLEY |
300 |
1,000 |
0.01% |
|
|
| 23 |
BANK OF AMERICA CORP /DE/ |
76 |
0 |
0.00% |
|
|
| 24 |
DEUTSCHE BANK AG\ |
68 |
0 |
0.00% |
|
|
| 25 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
257 |
0 |
0.00% |
|
|
| 26 |
JPMORGAN CHASE & CO |
100 |
0 |
0.00% |
|
|
